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SYMPK and HTT
Number of citations of the paper that reports this interaction (PMID
9700202
)
73
Data Source:
HPRD
(two hybrid)
SYMPK
HTT
Gene Name
symplekin
huntingtin
Image
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Cytoskeleton
Plasma Membrane
Tight Junction
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Late Endosome
Autophagic Vacuole
Endoplasmic Reticulum
Golgi Apparatus
Cytosol
Inclusion Body
Axon
Dendrite
Cytoplasmic Vesicle Membrane
Protein Complex
Molecular Function
Protein Binding
P53 Binding
Protein Binding
Transcription Factor Binding
Dynactin Binding
Identical Protein Binding
Ion Channel Binding
Dynein Intermediate Chain Binding
Beta-tubulin Binding
Diazepam Binding
Biological Process
MRNA Polyadenylation
Cell Adhesion
Positive Regulation Of Protein Dephosphorylation
Urea Cycle
Citrulline Metabolic Process
Establishment Of Mitotic Spindle Orientation
Protein Import Into Nucleus
ER To Golgi Vesicle-mediated Transport
Retrograde Vesicle-mediated Transport, Golgi To ER
Endoplasmic Reticulum Organization
Golgi Organization
Dopamine Receptor Signaling Pathway
Spermatogenesis
Cell Aging
Grooming Behavior
Locomotory Behavior
Axon Cargo Transport
Determination Of Adult Lifespan
Visual Learning
Anterior/posterior Pattern Specification
Endosomal Transport
Lactate Biosynthetic Process From Pyruvate
Quinolinate Biosynthetic Process
Striatum Development
Olfactory Lobe Development
Neural Plate Formation
Insulin Secretion
Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity
Regulation Of Protein Phosphatase Type 2A Activity
Social Behavior
Hormone Metabolic Process
Negative Regulation Of Neuron Apoptotic Process
Regulation Of Mitochondrial Membrane Permeability
Vesicle Transport Along Microtubule
Regulation Of Synaptic Plasticity
Paraxial Mesoderm Formation
Organ Development
Neuron Development
Neuron Apoptotic Process
Response To Calcium Ion
Regulation Of Mitochondrial Membrane Potential
L-glutamate Import
Iron Ion Homeostasis
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions
6 interactors:
CSTF2
HSF1
HTT
SSU72
SUMO1
TOP1
108 interactors:
AKT1
AMFR
AP2A2
CASP1
CASP3
CASP6
CBS
CHD3
CHUK
CREBBP
CRMP1
CTBP1
DLG4
DNALI1
DPPA4
DUSP10
ECH1
EGFR
ERCC6L
ETV4
EVL
F8A1
FEZ1
FICD
FTL
GAPDH
GGA2
GIT1
GOLPH3L
GPRASP2
GRB2
HAP1
HEYL
HIP1
HIP1R
HIST1H3H
HOXC11
HOXC4
HSPA8
HYPK
HYPM
IFT20
IKBKAP
IKBKB
IKBKG
ING5
KAT2B
KIAA1377
MAGEA3
MAGEB18
MAGEB6
MAP3K10
MBD1
MED21
MED31
MID1
MRFAP1
MRFAP1L1
MTSS1
NCOR1
NUPL1
OPTN
OSTF1
PACSIN1
PDK2
PEX11B
PFN2
PIAS1
PIAS4
PIK3R1
PML
PPP2CA
PRPF40A
PRPF40B
PSMC5
RASA1
REST
RNF20
RPS6KB1
SAP30
SETD2
SH3GL3
SH3GLB1
SIN3A
SP1
SUMO1
SYMPK
TACC1
TAF4
TBP
TCERG1
TGM2
TP53
TPR
TRAFD1
TRIP10
TTC23
TUBB
UBAC1
UBE2E3
UBE2K
UTP14A
VCP
XRCC6
ZDHHC17
ZFYVE19
ZNF451
ZNF655
Entrez ID
8189
3064
HPRD ID
09090
00883
Ensembl ID
ENSG00000125755
ENSG00000197386
Uniprot IDs
Q92797
P42858
PDB IDs
3O2Q
3O2S
3O2T
3ODR
3ODS
4H3H
4H3K
2D3X
2LD0
2LD2
3IO4
3IO6
3IOR
3IOT
3IOU
3IOV
3IOW
3LRH
4FE8
4FEB
4FEC
4FED
Enriched GO Terms of Interacting Partners
?
MRNA Polyadenylation
RNA Polyadenylation
Heterocycle Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
MRNA 3'-end Processing
Neural Plate Formation
RNA 3'-end Processing
Serotonin Uptake
Lactate Biosynthetic Process From Pyruvate
Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity
Negative Regulation Of Cerebellar Granule Cell Precursor Proliferation
Regulation Of Protein Phosphatase Type 2A Activity
Protein Localization To Nucleus
Circadian Rhythm
PML Body Organization
Quinolinate Biosynthetic Process
Dephosphorylation Of RNA Polymerase II C-terminal Domain
Negative Regulation Of Synaptic Transmission, Dopaminergic
Lactate Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity
Protein Localization To Nuclear Pore
Paraxial Mesoderm Formation
Quinolinate Metabolic Process
Protein Localization To Nuclear Envelope
Cellular Response To CGMP
Cellular Aromatic Compound Metabolic Process
Response To CGMP
Serotonin Transport
Regulation Of Gene Expression
Embryo Development
Sperm Ejaculation
Neural Plate Morphogenesis
L-glutamate Import
Regulation Of Developmental Growth
Rhythmic Process
Citrulline Metabolic Process
Embryonic Process Involved In Female Pregnancy
Lactate Metabolic Process
Urea Cycle
Embryonic Cleavage
Neurotransmitter Uptake
Urea Metabolic Process
Organelle Organization
Thalamus Development
Striatum Development
Paraxial Mesoderm Morphogenesis
Neural Plate Development
Amino Acid Import
Positive Regulation Of Cellular Metabolic Process
RNA Biosynthetic Process
Positive Regulation Of Metabolic Process
Gene Expression
RNA Metabolic Process
Transcription, DNA-templated
Organelle Organization
Nucleobase-containing Compound Metabolic Process
Regulation Of Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Regulation Of RNA Metabolic Process
Heterocycle Metabolic Process
Regulation Of Transcription, DNA-templated
Cellular Aromatic Compound Metabolic Process
Regulation Of Cellular Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Response To Growth Factor
Cellular Response To Organic Substance
Macromolecule Biosynthetic Process
Viral Process
Regulation Of Gene Expression
Negative Regulation Of Cellular Metabolic Process
Nitrogen Compound Metabolic Process
Cellular Response To Growth Factor Stimulus
Regulation Of Cellular Component Organization
Regulation Of Signal Transduction
Regulation Of Signaling
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Response To Organic Substance
Cellular Macromolecule Biosynthetic Process
Negative Regulation Of RNA Biosynthetic Process
Signaling
Cellular Metabolic Process
Cellular Response To Stress
Positive Regulation Of Gene Expression
Regulation Of Protein Metabolic Process
Developmental Process
Transcription From RNA Polymerase II Promoter
Cell Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Cell Communication
Regulation Of Transcription From RNA Polymerase II Promoter
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Protein Metabolic Process
Negative Regulation Of Biosynthetic Process
Tagcloud
?
1s
2a
3s
4c
4r
9r
aryl
carbomethoxy
carboxylic
dat
esters
ethylene
flattened
fluorophenyl
isomers
methylenedioxy
nortropane
paroxetine
phenoxy
piperidine
possesses
pseudoequatorial
reuptake
serotonin
ssri
stereochemistry
substituent
substituents
win
Tagcloud (Difference)
?
1s
2a
3s
4c
4r
9r
aryl
carbomethoxy
carboxylic
dat
esters
ethylene
flattened
fluorophenyl
isomers
methylenedioxy
nortropane
paroxetine
phenoxy
piperidine
possesses
pseudoequatorial
reuptake
serotonin
ssri
stereochemistry
substituent
substituents
win
Tagcloud (Intersection)
?