WNT11 and MDFI

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		WNT11	MDFI
Gene Name		wingless-type MMTV integration site family, member 11	MyoD family inhibitor
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Cytoplasm	Nucleus Cytoplasm
	Molecular Function	Ras GTPase Activator Activity Frizzled Binding Protein Kinase Activator Activity Transcription Regulatory Region DNA Binding	Protein Binding Transcription Factor Binding
	Biological Process	Osteoblast Differentiation Outflow Tract Morphogenesis Protein Phosphorylation Positive Regulation Of Gene Expression Neuron Differentiation Bone Mineralization Negative Regulation Of Cell Growth Adrenal Gland Development Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Response To Nutrient Levels Positive Regulation Of Ras GTPase Activity Positive Regulation Of Transforming Growth Factor Beta2 Production Protein Localization To Cell Surface Non-canonical Wnt Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Cell Fate Commitment Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Embryonic Skeletal System Development Artery Morphogenesis Positive Regulation Of Stress Fiber Assembly Palate Development Canonical Wnt Signaling Pathway Cloacal Septation Ventricular Septum Morphogenesis Lung-associated Mesenchyme Development Negative Regulation Of Cell Death Ureteric Bud Morphogenesis Negative Regulation Of Cartilage Development Neuroendocrine Cell Differentiation Tight Junction Assembly Cellular Response To Retinoic Acid Mesonephric Duct Development Negative Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Protein Kinase C Signaling Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Fibroblast Growth Factor Production	Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of JUN Kinase Activity Embryo Development Dorsal/ventral Axis Specification Negative Regulation Of Wnt Signaling Pathway Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of DNA Binding Embryonic Skeletal System Morphogenesis Trophoblast Giant Cell Differentiation
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Signaling by Wnt GPCR ligand binding Metabolic disorders of biological oxidation enzymes WNT ligand biogenesis and trafficking beta-catenin independent WNT signaling WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 Ca2+ pathway Signaling by WNT in cancer Class B/2 (Secretin family receptors) PCP/CE pathway
Drugs
Diseases
GWAS		PR interval ( 20062060)
Protein-Protein Interactions		3 interactors: KRTAP10-7 KRTAP10-9 MDFI	225 interactors: AANAT AASDHPPT ADAMTSL3 AKAP17A AP5Z1 APLN AQP1 AQP5 ARHGAP32 ARID5A ATG12 ATN1 ATXN7L2 AVPI1 B3GNT9 BAALC BAHD1 BBS2 BEX1 C10orf62 C14orf105 C17orf70 C19orf60 C19orf66 C20orf195 C22orf39 C4orf26 C5orf30 C6orf165 C8orf33 C8orf48 CATSPER1 CBFA2T2 CBX2 CC2D1B CCDC116 CCDC120 CCDC185 CCDC33 CCER1 CDC42EP1 CDCA7L CDKL3 CEP57L1 CHIC2 CLPB CNNM3 CPSF3L CREB5 CRX CRY1 CSNK1G2-AS1 CXCL16 CYBA DAAM2 DBF4B DCAF8 DCANP1 DDX19A DHRS1 DKK1 DMRT3 DNPEP DOCK2 DUSP6 EBI3 EIF4A2 EIF4E2 ENKD1 ETNK2 EWSR1 FAM124B FAM161A FAM27E3 FASTK FBXL18 FBXO34 FBXW5 FES FOXD4L6 FZD9 GATA2 GDF15 GLIDR GNAI2 GNG5 GPATCH2L GPRIN2 GTF3C5 HEYL HNRNPLL HOXA1 HOXB9 HTR1B ILF3 IQUB KAT5 KIAA0040 KIAA0408 KIF1A KPNA2 KRAS LASP1 LCE1B LCE3E LCE4A LIMS2 LINC00636 LINC01588 LMO3 LOC148413 LOC149950 LRCH4 LRRN4 MAGED1 MAGEF1 MAPKBP1 MCM5 METTL17 MFSD3 MGAT5B MVP MYF5 MYOD1 MYOG NAB2 NDUFA7 NEU4 NPDC1 NR1H2 NR1H3 OLIG3 OTX1 PARP11 PBXIP1 PDGFB PDIA5 PGLS PHLDA1 PID1 PIDD1 PIH1D2 PIN1 PLEKHG4 POM121L8P PRKAB2 PTPMT1 PVRL2 RABL6 REG3A RFX2 RIPPLY1 RTP5 SERF2 SFI1 SIX1 SLC25A10 SLC35A2 SLC9A1 SPATA3 SPATA8 SPG7 SPRY1 SPRY2 TAP1 TCEB3 TCF3 TGIF1 THAP7 THEG TIE1 TINAGL1 TMEM241 TNNI1 TNP2 TRAF3IP2 TRPC1 TRPV6 TSC2 TTC23 TTLL10 TUSC2 TYMSOS TYRO3 UBC USP20 USP6 VHL VPS72 WDYHV1 WNT11 ZBTB24 ZBTB25 ZBTB9 ZFYVE26 ZNF101 ZNF124 ZNF136 ZNF138 ZNF155 ZNF205 ZNF223 ZNF230 ZNF264 ZNF266 ZNF408 ZNF417 ZNF426 ZNF433 ZNF439 ZNF440 ZNF490 ZNF559 ZNF564 ZNF578 ZNF581 ZNF587 ZNF607 ZNF646 ZNF670 ZNF679 ZNF707 ZNF764 ZNF79 ZNF844
Entrez ID		7481	4188
HPRD ID		04741	07280
Ensembl ID		ENSG00000085741	ENSG00000112559
Uniprot IDs		O96014	B1AKB6 Q99750
PDB IDs
Enriched GO Terms of Interacting Partners?		Trophoblast Giant Cell Differentiation Cytoplasmic Sequestering Of Transcription Factor Dorsal/ventral Axis Specification Cytoplasmic Sequestering Of Protein Cell Differentiation Involved In Embryonic Placenta Development Activation Of JUN Kinase Activity Negative Regulation Of DNA Binding Negative Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of JUN Kinase Activity Negative Regulation Of Protein Import Into Nucleus Regulation Of JUN Kinase Activity Negative Regulation Of Protein Localization To Nucleus Regulation Of DNA Binding JNK Cascade Negative Regulation Of Intracellular Protein Transport Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Binding Axis Specification Embryonic Placenta Development Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Intracellular Transport Dorsal/ventral Pattern Formation Positive Regulation Of JNK Cascade Embryonic Skeletal System Morphogenesis Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Activation Of MAPK Activity Maintenance Of Protein Location In Cell Maintenance Of Protein Location Maintenance Of Location In Cell Regulation Of JNK Cascade Embryonic Skeletal System Development Regulation Of Protein Import Into Nucleus Negative Regulation Of Protein Transport Regulation Of Stress-activated MAPK Cascade Placenta Development Negative Regulation Of Wnt Signaling Pathway Regulation Of Protein Localization To Nucleus Positive Regulation Of MAP Kinase Activity Regulation Of Nucleocytoplasmic Transport MAPK Cascade Regulation Of Binding Regulation Of Intracellular Protein Transport Activation Of Protein Kinase Activity Skeletal System Morphogenesis Positive Regulation Of Protein Serine/threonine Kinase Activity Signal Transduction By Phosphorylation Regulation Of MAP Kinase Activity Regulation Of Wnt Signaling Pathway	Transcription, DNA-templated RNA Biosynthetic Process Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Gene Expression Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Biosynthetic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Cellular Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Cellular Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Cellular Metabolic Process Negative Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Developmental Process Cellular Response To Organic Substance Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Multicellular Organismal Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Differentiation Positive Regulation Of Myoblast Fusion Cell Fate Commitment Positive Regulation Of Skeletal Muscle Fiber Development Anatomical Structure Development Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Regulation Of Myoblast Fusion Transcription From RNA Polymerase II Promoter Organ Development Metabolic Process
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