WNT11

Gene Name		wingless-type MMTV integration site family, member 11
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Cytoplasm
	Molecular Function	Ras GTPase Activator Activity Frizzled Binding Protein Kinase Activator Activity Transcription Regulatory Region DNA Binding
	Biological Process	Osteoblast Differentiation Outflow Tract Morphogenesis Protein Phosphorylation Positive Regulation Of Gene Expression Neuron Differentiation Bone Mineralization Negative Regulation Of Cell Growth Adrenal Gland Development Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Response To Nutrient Levels Positive Regulation Of Ras GTPase Activity Positive Regulation Of Transforming Growth Factor Beta2 Production Protein Localization To Cell Surface Non-canonical Wnt Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Cell Fate Commitment Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Embryonic Skeletal System Development Artery Morphogenesis Positive Regulation Of Stress Fiber Assembly Palate Development Canonical Wnt Signaling Pathway Cloacal Septation Ventricular Septum Morphogenesis Lung-associated Mesenchyme Development Negative Regulation Of Cell Death Ureteric Bud Morphogenesis Negative Regulation Of Cartilage Development Neuroendocrine Cell Differentiation Tight Junction Assembly Cellular Response To Retinoic Acid Mesonephric Duct Development Negative Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Protein Kinase C Signaling Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Fibroblast Growth Factor Production
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Signaling by Wnt GPCR ligand binding Metabolic disorders of biological oxidation enzymes WNT ligand biogenesis and trafficking beta-catenin independent WNT signaling WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 Ca2+ pathway Signaling by WNT in cancer Class B/2 (Secretin family receptors) PCP/CE pathway
Drugs
Diseases
GWAS		PR interval ( 20062060)
Protein-protein Interactions		3 interactors: KRTAP10-7 KRTAP10-9 MDFI
Entrez ID		7481
HPRD ID		04741
Ensembl ID		ENSG00000085741
Uniprot IDs		O96014
PDB IDs
Enriched GO Terms of Interacting Partners?		Trophoblast Giant Cell Differentiation Cytoplasmic Sequestering Of Transcription Factor Dorsal/ventral Axis Specification Cytoplasmic Sequestering Of Protein Cell Differentiation Involved In Embryonic Placenta Development Activation Of JUN Kinase Activity Negative Regulation Of DNA Binding Negative Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of JUN Kinase Activity Negative Regulation Of Protein Import Into Nucleus Regulation Of JUN Kinase Activity Negative Regulation Of Protein Localization To Nucleus Regulation Of DNA Binding JNK Cascade Negative Regulation Of Intracellular Protein Transport Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Binding Axis Specification Embryonic Placenta Development Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Intracellular Transport Dorsal/ventral Pattern Formation Positive Regulation Of JNK Cascade Embryonic Skeletal System Morphogenesis Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Activation Of MAPK Activity Maintenance Of Protein Location In Cell Maintenance Of Protein Location Maintenance Of Location In Cell Regulation Of JNK Cascade Embryonic Skeletal System Development Regulation Of Protein Import Into Nucleus Negative Regulation Of Protein Transport Regulation Of Stress-activated MAPK Cascade Placenta Development Negative Regulation Of Wnt Signaling Pathway Regulation Of Protein Localization To Nucleus Positive Regulation Of MAP Kinase Activity Regulation Of Nucleocytoplasmic Transport MAPK Cascade Regulation Of Binding Regulation Of Intracellular Protein Transport Activation Of Protein Kinase Activity Skeletal System Morphogenesis Positive Regulation Of Protein Serine/threonine Kinase Activity Signal Transduction By Phosphorylation Regulation Of MAP Kinase Activity Regulation Of Wnt Signaling Pathway
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