WNT11 and KRTAP5-8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		WNT11	KRTAP5-8
Description		Wnt family member 11	keratin associated protein 5-8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Extracellular Matrix	Cytosol Intermediate Filament
	Molecular Function	Signaling Receptor Binding Frizzled Binding Cytokine Activity Protein Binding Protein Kinase Activator Activity	Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Osteoblast Differentiation Kidney Development Epithelial To Mesenchymal Transition Primary Heart Field Specification Secondary Heart Field Specification Outflow Tract Morphogenesis Ventricular Septum Development Atrial Septum Development Apoptotic Process Signal Transduction Wnt Signaling Pathway, Calcium Modulating Pathway Mesenchymal Cell Proliferation Wnt Signaling Pathway Cell Differentiation Neuron Differentiation Bone Mineralization Adrenal Gland Development Response To Nutrient Levels Positive Regulation Of Transforming Growth Factor Beta2 Production Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Positive Regulation Of Apoptotic Process Cell Fate Commitment Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of DNA-templated Transcription Paraxial Mesoderm Formation Notochord Morphogenesis Embryonic Skeletal System Development Artery Morphogenesis Roof Of Mouth Development Convergent Extension Involved In Axis Elongation Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Cloacal Septation Ventricular Septum Morphogenesis Lung-associated Mesenchyme Development Ureteric Bud Morphogenesis Negative Regulation Of Cartilage Development Somite Development Neuroendocrine Cell Differentiation Secondary Palate Development Bicellular Tight Junction Assembly Cellular Response To Mechanical Stimulus Cellular Response To Retinoic Acid Stem Cell Proliferation Mesonephric Duct Development Negative Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Fibroblast Growth Factor Production Epithelial Cell Apoptotic Process Positive Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Stem Cell Proliferation
Pathways		WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors) Ca2+ pathway Ca2+ pathway PCP/CE pathway PCP/CE pathway Formation of the ureteric bud	Keratinization
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 30929738 31619474) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Platelet count ( 32888494) Plateletcrit ( 32888494) PR interval ( 20062060 30046033 32439900) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Thumb osteoarthritis severity (hand Klsum) ( 33055079)
Interacting Genes		17 interacting genes: CCNDBP1 CYSRT1 FUCA2 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP17-1 KRTAP5-7 KRTAP5-8 KRTAP5-9 KRTAP9-3 MDFI RASSF10	6 interacting genes: CRCT1 HHEX LCE1E LCE3A LCE5A WNT11
Entrez ID		7481	57830
HPRD ID		04741	17252
Ensembl ID		ENSG00000085741	ENSG00000241233
Uniprot IDs		M4IS22 O96014	O75690
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Cytosol Identical Protein Binding Structural Constituent Of Skin Epidermis Alpha-L-fucosidase Activity	Keratinization Epidermis Development Tissue Development Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Transcription By Competitive Promoter Binding Regulation Of MRNA Export From Nucleus Negative Regulation Of Cytoplasmic Translational Initiation Eukaryotic Initiation Factor 4E Binding Regionalization Secondary Palate Development Notochord Morphogenesis Nephron Tubule Morphogenesis Convergent Extension Involved In Axis Elongation Lung-associated Mesenchyme Development Negative Regulation Of Fibroblast Growth Factor Production Maintenance Of Epithelial Cell Apical/basal Polarity Primary Heart Field Specification Ureteric Bud Morphogenesis Wnt Signaling Pathway, Calcium Modulating Pathway Convergent Extension Cloacal Septation Positive Regulation Of Transforming Growth Factor Beta2 Production Atrial Septum Development Nephric Duct Development Regulation Of Transforming Growth Factor Beta2 Production Heart Field Specification Mesonephric Duct Development Negative Regulation Of Mesenchymal Cell Proliferation Paraxial Mesoderm Formation Secondary Heart Field Specification Maintenance Of Cell Polarity Regulation Of Wnt Signaling Pathway DNA Binding, Bending Somite Development Regulation Of RNA Export From Nucleus Translation Regulator Activity DNA Conformation Change Specification Of Animal Organ Identity Renal Tubule Morphogenesis Neuroendocrine Cell Differentiation Positive Regulation Of Transforming Growth Factor Beta Production Pattern Specification Process Positive Regulation Of Epithelial Cell Apoptotic Process Adrenal Gland Development TBP-class Protein Binding Mesenchymal Cell Proliferation
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