WNT11 and KRTAP12-3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		WNT11	KRTAP12-3
Description		Wnt family member 11	keratin associated protein 12-3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Extracellular Matrix	Cytosol Intermediate Filament Keratin Filament
	Molecular Function	Signaling Receptor Binding Frizzled Binding Cytokine Activity Protein Binding Protein Kinase Activator Activity	Protein Binding Identical Protein Binding
	Biological Process	Osteoblast Differentiation Kidney Development Epithelial To Mesenchymal Transition Primary Heart Field Specification Secondary Heart Field Specification Outflow Tract Morphogenesis Ventricular Septum Development Atrial Septum Development Apoptotic Process Signal Transduction Wnt Signaling Pathway, Calcium Modulating Pathway Mesenchymal Cell Proliferation Wnt Signaling Pathway Cell Differentiation Neuron Differentiation Bone Mineralization Adrenal Gland Development Response To Nutrient Levels Positive Regulation Of Transforming Growth Factor Beta2 Production Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Positive Regulation Of Apoptotic Process Cell Fate Commitment Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of DNA-templated Transcription Paraxial Mesoderm Formation Notochord Morphogenesis Embryonic Skeletal System Development Artery Morphogenesis Roof Of Mouth Development Convergent Extension Involved In Axis Elongation Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Cloacal Septation Ventricular Septum Morphogenesis Lung-associated Mesenchyme Development Ureteric Bud Morphogenesis Negative Regulation Of Cartilage Development Somite Development Neuroendocrine Cell Differentiation Secondary Palate Development Bicellular Tight Junction Assembly Cellular Response To Mechanical Stimulus Cellular Response To Retinoic Acid Stem Cell Proliferation Mesonephric Duct Development Negative Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Fibroblast Growth Factor Production Epithelial Cell Apoptotic Process Positive Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Stem Cell Proliferation
Pathways		WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors) Ca2+ pathway Ca2+ pathway PCP/CE pathway PCP/CE pathway Formation of the ureteric bud	Keratinization
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 30929738 31619474) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Platelet count ( 32888494) Plateletcrit ( 32888494) PR interval ( 20062060 30046033 32439900) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Thumb osteoarthritis severity (hand Klsum) ( 33055079)
Interacting Genes		17 interacting genes: CCNDBP1 CYSRT1 FUCA2 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP17-1 KRTAP5-7 KRTAP5-8 KRTAP5-9 KRTAP9-3 MDFI RASSF10	145 interacting genes: ADAMTSL3 ADAMTSL4 AGXT ALDH3B1 BCL6B BMP7 C11orf87 C22orf39 CARD10 CATSPER1 CBX2 CELF5 CHIC2 CHRD CHRNG CNNM3 COL8A1 CRCT1 CREB5 CYSRT1 DALRD3 DHRS1 DHX57 DNAL4 DOCK2 FASLG FBXW5 GLRX3 GNE GTF3C5 HOXA1 ITGB4 JOSD1 KPRP KRT20 KRTAP1-1 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP13-1 KRTAP13-2 KRTAP13-3 KRTAP19-7 KRTAP3-3 KRTAP4-2 KRTAP4-4 KRTAP5-6 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP9-2 KRTAP9-3 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LCE4A LCE5A LIF LMNTD2 LNX1 LYVE1 MAPKBP1 MEOX2 MISP MOBP NBPF19 NKD1 NMU NOTCH2NLA NPDC1 NR1D2 NR4A3 NUFIP2 OTX1 OXER1 P2RX4 P2RY6 P3H3 P4HB PDE9A PDGFRB PGAP6 PHLDA1 POU4F2 PTGDS PTPMT1 R3HDM2 RSPO2 SELENOM SHFL SLC13A5 SLC15A2 SLC23A1 SMCP SPATA3 SPRY1 TCEA2 TCEANC TFAP2D TMIE TNP2 TNS2 TTPA UTP23 UXT VASN VGLL3 VSTM4 WDR25 WNT11 YY1 ZDHHC1 ZNF101 ZNF124 ZNF138 ZNF20 ZNF408 ZNF417 ZNF439 ZNF440 ZNF467 ZNF490 ZNF491 ZNF497 ZNF578 ZNF587 ZNF648 ZNF696 ZNF80 ZNF835 ZNF837 ZSCAN21
Entrez ID		7481	386683
HPRD ID		04741	11199
Ensembl ID		ENSG00000085741	ENSG00000205439
Uniprot IDs		M4IS22 O96014	P60328
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Cytosol Identical Protein Binding Structural Constituent Of Skin Epidermis Alpha-L-fucosidase Activity	Keratinization Intermediate Filament Epidermis Development Keratin Filament Protein Binding Tissue Development DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Regulation Of Transcription By RNA Polymerase II Identical Protein Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
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