SLC14A2 and PLP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLC14A2	PLP2
Description		solute carrier family 14 member 2	proteolipid protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Apical Plasma Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane
	Molecular Function	Protein Binding Urea Transmembrane Transporter Activity Cell Adhesion Molecule Binding	Protein Binding Monoatomic Ion Transmembrane Transporter Activity Chemokine Binding
	Biological Process	Urea Transport Transmembrane Transport Urea Transmembrane Transport	Monoatomic Ion Transport Chemotaxis Cytokine-mediated Signaling Pathway Monoatomic Ion Transmembrane Transport
Pathways		SLC-mediated transport of organic cations
Drugs
Diseases
GWAS		Biochemical measures ( 19260141) Bladder cancer ( 24163127) Blood urea nitrogen levels ( 31152163 29403010) Cerebrospinal fluid clusterin levels ( 26545630) Cocaine dependence ( 31212010) FEV1 ( 30804560) Follicular lymphoma ( 25279986) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hematological and biochemical traits ( 20139978) Hemoglobin ( 32888494) Intake of total sugars ( 31005972) Lateral orbital frontal cortex volume ( 31530798) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Male-pattern baldness ( 28196072 27182965) Menarche (age at onset) ( 21102462) Metabolite levels ( 23823483 21909109) Nicotine withdrawal ( 29532581) Nicotine withdrawal symptom count ( 29532581) Pulse pressure ( 27841878 28135244) Red blood cell count ( 32888494) Refractive error ( 32231278) Renal function-related traits (BUN) ( 22797727) Smoking status (ever vs never smokers) ( 30643258) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969) Systolic blood pressure ( 27841878) Takayasu arteritis ( 33308445) Urate levels ( 31578528)	Platelet distribution width ( 32888494)
Interacting Genes		12 interacting genes: ARLN CMTM7 EHHADH LAT LRP10 PLN PLP2 SEC22A TMEM97 TNF TRARG1 VAMP5	79 interacting genes: AQP2 AQP3 AQP6 AQP8 ARFIP2 ARL13B ASGR2 ATP5PF BCAP31 BIK BNIP3 CCR1 CD53 CD79A CERS4 CIAO2A CLDN5 CLN8 CPLX4 CRB3 CREB3L1 CYB561 CYBC1 CYBRD1 DARS2 DLGAP4 DNAJC1 EBP ELOVL5 ELP1 EVI2A FAM209A FAM210B FATE1 FCER1G FKBP7 FNDC9 GPR151 GPX8 HSBP1L1 HSD17B11 HSD17B13 KASH5 LHFPL1 LHFPL5 LMNA LRRC4C MGST3 MUC1 NDRG4 PACC1 PDZK1IP1 PIGP PSCA PTGES PVR REEP4 RETREG3 RNF5 SAR1A SCN3B SGPL1 SHBG SLC10A6 SLC14A2 SLC18A1 SLC2A13 SLC35H1 SPG21 SPN THAP4 TM4SF19 TMEM14B TMEM31 TMEM51 TMEM79 TMPRSS2 TMX2 VKORC1
Entrez ID		8170	5355
HPRD ID		03366	02121
Ensembl ID		ENSG00000132874	ENSG00000102007
Uniprot IDs		Q15849	Q04941
PDB IDs		8BLO 8XD7 8XD9 8XDA 8XDB 8XDC 8XDD 8XDE
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Heart Rate Negative Regulation Of Blood Circulation Negative Regulation Of Heart Contraction Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Intramolecular Oxidoreductase Activity, Transposing C=C Bonds Regulation Of The Force Of Heart Contraction By Cardiac Conduction Calcium Ion-transporting ATPase Complex Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Calcium-mediated Signaling Circadian Sleep/wake Cycle, Sleep Phospholamban Complex Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Membrane Negative Regulation Of Bile Acid Secretion Protein Localization To Cell Periphery Localization Within Membrane Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Chronic Inflammatory Response To Antigenic Stimulus Protein Localization To Plasma Membrane Response To Gram-negative Bacterium Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Negative Regulation Of L-glutamate Import Across Plasma Membrane Positive Regulation Of Fractalkine Production Negative Regulation Of Branching Involved In Lung Morphogenesis Positive Regulation Of Blood Microparticle Formation Response To Gold Nanoparticle Protein Localization To Membrane Positive Regulation Of Vitamin D Biosynthetic Process Establishment Of Protein Localization To Plasma Membrane Vesicle-mediated Transport TCR Signalosome B-1a B Cell Differentiation	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding Water Channel Activity Water Transport Renal Water Transport One-carbon Compound Transport Urea Transmembrane Transport Urea Transport Fluid Transport PH-gated Chloride Channel Activity Mitochondrial Membrane Channel Activity Apical Plasma Membrane Ascorbate Homeostasis Steroid Dehydrogenase Activity Organic Hydroxy Compound Transport Endoplasmic Reticulum-autophagosome Adaptor Activity Transmembrane Monodehydroascorbate Reductase Activity Glutathione Peroxidase Activity Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Transmembrane Transport Urea Transmembrane Transporter Activity Identical Protein Binding Glycerol Transmembrane Transport Plasma Membrane Substrate Localization To Autophagosome Ammonium Channel Activity Polyol Transmembrane Transport
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