SLC14A2 and VAMP5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLC14A2	VAMP5
Description		solute carrier family 14 member 2	vesicle associated membrane protein 5
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Apical Plasma Membrane	Late Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Cell Surface Endomembrane System Intercalated Disc Membrane Cytoplasmic Vesicle Membrane Organelle Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding Urea Transmembrane Transporter Activity Cell Adhesion Molecule Binding	Protein Binding
	Biological Process	Urea Transport Transmembrane Transport Urea Transmembrane Transport	Muscle Organ Development Skeletal Muscle Tissue Development Vesicle-mediated Transport Cell Differentiation Golgi To Plasma Membrane Protein Transport
Pathways		SLC-mediated transport of organic cations
Drugs
Diseases
GWAS		Biochemical measures ( 19260141) Bladder cancer ( 24163127) Blood urea nitrogen levels ( 31152163 29403010) Cerebrospinal fluid clusterin levels ( 26545630) Cocaine dependence ( 31212010) FEV1 ( 30804560) Follicular lymphoma ( 25279986) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hematological and biochemical traits ( 20139978) Hemoglobin ( 32888494) Intake of total sugars ( 31005972) Lateral orbital frontal cortex volume ( 31530798) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Male-pattern baldness ( 28196072 27182965) Menarche (age at onset) ( 21102462) Metabolite levels ( 23823483 21909109) Nicotine withdrawal ( 29532581) Nicotine withdrawal symptom count ( 29532581) Pulse pressure ( 27841878 28135244) Red blood cell count ( 32888494) Refractive error ( 32231278) Renal function-related traits (BUN) ( 22797727) Smoking status (ever vs never smokers) ( 30643258) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969) Systolic blood pressure ( 27841878) Takayasu arteritis ( 33308445) Urate levels ( 31578528)	Appendicular lean mass ( 33097823) Coronary artery disease ( 26343387 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Myocardial infarction ( 26343387) Platelet distribution width ( 32888494) Prostate cancer ( 21743467) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		12 interacting genes: ARLN CMTM7 EHHADH LAT LRP10 PLN PLP2 SEC22A TMEM97 TNF TRARG1 VAMP5	57 interacting genes: ABHD16A AQP6 ARL13B ASGR2 ATP6AP2 BIK CD53 CLDN5 CLDN7 COMT CPLX4 CYB5R3 ELOVL4 ERGIC3 FAM209A FNDC9 GJA8 GORAB GPR152 GPX8 GRAMD2B HIBADH HSD17B13 IL3RA JAGN1 KIR2DL3 KIR3DL3 KLRC1 LMNA LRRC25 MDC1 MUC1 NCAPH2 PANX1 PLAC8 PVR RETREG3 SAR1A SLC14A2 SLC18A1 SPINT1 STX1A STX1B STX2 TAS2R5 TM4SF18 TMCO5A TMEM106C TMEM139 TMEM14B TMEM31 TMEM45B TMEM52B TMEM86B TMPRSS2 TMX2 VSIG4
Entrez ID		8170	10791
HPRD ID		03366	09513
Ensembl ID		ENSG00000132874	ENSG00000168899
Uniprot IDs		Q15849	O95183 Q6FG93
PDB IDs		8BLO 8XD7 8XD9 8XDA 8XDB 8XDC 8XDD 8XDE
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Heart Rate Negative Regulation Of Blood Circulation Negative Regulation Of Heart Contraction Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Intramolecular Oxidoreductase Activity, Transposing C=C Bonds Regulation Of The Force Of Heart Contraction By Cardiac Conduction Calcium Ion-transporting ATPase Complex Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Calcium-mediated Signaling Circadian Sleep/wake Cycle, Sleep Phospholamban Complex Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Membrane Negative Regulation Of Bile Acid Secretion Protein Localization To Cell Periphery Localization Within Membrane Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Chronic Inflammatory Response To Antigenic Stimulus Protein Localization To Plasma Membrane Response To Gram-negative Bacterium Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Negative Regulation Of L-glutamate Import Across Plasma Membrane Positive Regulation Of Fractalkine Production Negative Regulation Of Branching Involved In Lung Morphogenesis Positive Regulation Of Blood Microparticle Formation Response To Gold Nanoparticle Protein Localization To Membrane Positive Regulation Of Vitamin D Biosynthetic Process Establishment Of Protein Localization To Plasma Membrane Vesicle-mediated Transport TCR Signalosome B-1a B Cell Differentiation	Membrane Protein Binding SNARE Complex Endoplasmic Reticulum Membrane SNARE Binding Endoplasmic Reticulum Presynaptic Active Zone Membrane Synaptic Vesicle Exocytosis Monoatomic Anion Channel Activity Signal Release Norepinephrine Transport Structural Molecule Activity SNAP Receptor Activity Neurotransmitter Transport Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane Exocytosis Regulation Of Synaptic Vesicle Priming
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