KIF19 and HTR2B

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		KIF19	HTR2B
Description		kinesin family member 19	5-hydroxytryptamine receptor 2B
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Kinesin Complex Microtubule Cilium Axoneme Cell Projection	Nucleoplasm Cytoplasm Plasma Membrane Membrane Dendrite Neuron Projection Synapse G Protein-coupled Serotonin Receptor Complex
	Molecular Function	Nucleotide Binding Microtubule Motor Activity ATP Binding Microtubule Binding Plus-end-directed Microtubule Motor Activity ATP Hydrolysis Activity	Gq/11-coupled Serotonin Receptor Activity G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity GTPase Activator Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Binding Serotonin Receptor Activity
	Biological Process	Microtubule-based Movement Axonemal Microtubule Depolymerization Plus-end Specific Microtubule Depolymerization	Neural Crest Cell Migration Positive Regulation Of Cytokine Production Positive Regulation Of Endothelial Cell Proliferation Heart Morphogenesis Cardiac Muscle Hypertrophy Intracellular Calcium Ion Homeostasis Smooth Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Heart Development Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Positive Regulation Of Phosphatidylinositol Biosynthetic Process Neural Crest Cell Differentiation Intestine Smooth Muscle Contraction Calcium-mediated Signaling CGMP-mediated Signaling Vasoconstriction Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Embryonic Morphogenesis Regulation Of Behavior Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cell Division ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways		COPI-dependent Golgi-to-ER retrograde traffic Kinesins	Serotonin receptors G alpha (q) signalling events
Drugs			Methysergide Cabergoline Zolmitriptan Dihydroergotamine Methylergometrine Cyproheptadine Chlorpromazine Triflupromazine Amoxapine Fenfluramine Lisuride Ergotamine Apomorphine Paroxetine Paroxetine Minaprine Cyclobenzaprine Ergoloid mesylate Tegaserod Doxepin Pergolide Bromocriptine Ketamine Aripiprazole Chlorprothixene Clomipramine Yohimbine Midomafetamine Lysergic acid diethylamide OPC-28326 Epicept NP-1 PRX-08066 Cariprazine Mianserin Pizotifen Asenapine Ocaperidone Esmirtazapine Nandrolone decanoate Viloxazine Pipamperone Setiptiline Dihydroergocornine Gilteritinib Tiapride Dihydroergocristine
Diseases
GWAS			Proportion of activated microglia (midfrontal cortex) ( 30679421) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		5 interacting genes: AKAP9 HTR2B MAPRE3 NDEL1 RBM5	27 interacting genes: ABCA3 ATP1B1 BNIP3 BNIP3L CBR1 CHPT1 G6PC3 GNA11 GNAQ HAT1 HDGFL2 INSIG1 KIF19 LNX1 MATR3 METRN NAT14 NIPA2 OAZ1 PLLP PPP1R3F RAE1 SLC31A2 SLC37A1 SLC44A2 SNTA1 TRAM1L1
Entrez ID		124602	3357
HPRD ID		08782	03077
Ensembl ID		ENSG00000196169	ENSG00000135914
Uniprot IDs		Q2TAC6	P41595
PDB IDs			4IB4 4NC3 5TUD 5TVN 6DRX 6DRY 6DRZ 6DS0 7SRQ 7SRR 7SRS
Enriched GO Terms of Interacting Partners?		Microtubule Organizing Center Microtubule Nucleation Centrosome Localization Regulation Of Microtubule Polymerization Microtubule Cytoskeleton Organization Regulation Of Microtubule Polymerization Or Depolymerization Gq/11-coupled Serotonin Receptor Activity Positive Regulation Of Phosphatidylinositol Biosynthetic Process G Protein-coupled Serotonin Receptor Complex Intestine Smooth Muscle Contraction Maintenance Of Centrosome Location Regulation Of Microtubule Cytoskeleton Organization Potassium Channel Activator Activity Cytoskeleton Organization Dendritic Branch Extrinsic Component Of Postsynaptic Density Membrane Microtubule-based Process Mitotic Spindle Astral Microtubule End Microtubule End Radial Glia-guided Pyramidal Neuron Migration Neurofilament Cytoskeleton Mitotic Centrosome Separation Phospholipase C-activating Serotonin Receptor Signaling Pathway Regulation Of Microtubule-based Process Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Microtubule Binding Neuron To Neuron Synapse Axon Hillock Positive Regulation Of Cellular Component Organization Potassium Channel Complex Serotonin Binding Serotonin Receptor Signaling Pathway Neurofilament Cytoskeleton Organization Positive Regulation Of Phospholipid Biosynthetic Process Chemical Synaptic Transmission Serotonin Receptor Activity Neural Crest Cell Differentiation Centrosome Separation G Protein-coupled Serotonin Receptor Activity Trans-synaptic Signaling Synaptic Signaling Protein Localization To Microtubule Microtubule Positive Regulation Of Ruffle Assembly Positive Regulation Of Cell Projection Organization Inner Cell Mass Cell Proliferation Regulation Of Phospholipid Biosynthetic Process Neurotransmitter Receptor Activity Regulation Of Golgi Organization Cytoskeleton	Glucose-6-phosphate Transport Phosphatidylcholine Metabolic Process Mitochondrial Protein Catabolic Process Negative Regulation Of Membrane Potential Negative Regulation Of Mitochondrial Membrane Potential Mitochondrial Outer Membrane Permeabilization Phospholipase C-activating Serotonin Receptor Signaling Pathway Phototransduction, Visible Light Lysosomal Membrane Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Mitochondrial Envelope Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death Guanyl Nucleotide Binding Regulation Of Membrane Potential G Protein-coupled Acetylcholine Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Signaling Pathway Phosphatidylcholine Biosynthetic Process Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Detection Of Visible Light Positive Regulation Of Mitochondrial Membrane Permeability Cellular Response To PH Entrainment Of Circadian Clock Enzyme Regulator Activity Positive Regulation Of Protein Homooligomerization Organophosphate Ester Transport Transmembrane Transport Glycerolipid Metabolic Process Lamellar Body Membrane Membrane Positive Regulation Of Membrane Permeability Mitochondrion Autophagosome Adaptor Activity Prostaglandin E2 9-reductase Activity 15-hydroxyprostaglandin Dehydrogenase (NADP+) Activity Regulation Of Copper Ion Transmembrane Transport Heterotrimeric G-protein Complex Negative Regulation Of Cargo Loading Into COPII-coated Vesicle Plus-end Specific Microtubule Depolymerization Axonemal Microtubule Depolymerization Regulation Of Sodium Ion Transmembrane Transport Response To PH Phototransduction Acetylcholine Receptor Signaling Pathway
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