TMX1 and SPI1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TMX1	SPI1
Gene Name		thioredoxin-related transmembrane protein 1	Spi-1 proto-oncogene
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Nuclear Chromatin
	Molecular Function	Protein Disulfide Isomerase Activity Disulfide Oxidoreductase Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Core Promoter Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Transcription Factor Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity RNA Binding Protein Binding NFAT Protein Binding
	Biological Process	Protein Folding Response To Endoplasmic Reticulum Stress Cell Redox Homeostasis Oxidation-reduction Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Lymphoid Progenitor Cell Differentiation Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Lymphocyte Differentiation Erythrocyte Differentiation Macrophage Differentiation Granulocyte Differentiation Somatic Stem Cell Maintenance Myeloid Dendritic Cell Differentiation Histone H3 Acetylation Hypermethylation Of CpG Island Negative Regulation Of MHC Class II Biosynthetic Process Regulation Of Erythrocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Regression Negative Regulation Of Histone H4 Acetylation Apoptotic Process Involved In Patterning Of Blood Vessels
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: FAS SPI1 SULT2A1	43 interactors: ATF1 BCL6 CEBPA CEBPB CEBPD CEBPE CREBBP CREM CSNK2A1 DNMT3A DNMT3B ERG ETS1 ETS2 ETV1 FOS FUS GATA1 GATA2 GATA3 GFI1 HDAC1 HOXA10 IRF1 IRF4 IRF8 JUN KAT6A MAPK8 MECP2 MITF NFATC1 NFKB1 NFYA NONO PIP RB1 SIN3A SKI SPIB SSRP1 TBP TMX1
Entrez ID		81542	6688
HPRD ID		15590	01305
Ensembl ID			ENSG00000066336
Uniprot IDs		B4DZX7 Q9H3N1	P17947
PDB IDs		1X5E
Enriched GO Terms of Interacting Partners?		Regulation Of Myeloid Cell Differentiation Motor Neuron Apoptotic Process Lymphocyte Differentiation Homeostasis Of Number Of Cells Bile Acid Catabolic Process Hypermethylation Of CpG Island Leukocyte Differentiation Sulfur Compound Metabolic Process Necroptotic Signaling Pathway Negative Regulation Of MHC Class II Biosynthetic Process Transformed Cell Apoptotic Process Activation-induced Cell Death Of T Cells Lymphocyte Activation Apoptotic Process Involved In Patterning Of Blood Vessels Inflammatory Cell Apoptotic Process Cellular Response To Hyperoxia Negative Regulation Of Histone H4 Acetylation Positive Regulation Of Protein Homooligomerization Leukocyte Activation Lymphoid Progenitor Cell Differentiation Pantothenate Metabolic Process Monocarboxylic Acid Metabolic Process Negative Thymic T Cell Selection Negative T Cell Selection Long-chain Fatty-acyl-CoA Biosynthetic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Granulocyte Differentiation Hemopoiesis Regulation Of Histone H4 Acetylation Cellular Response To Lithium Ion T Cell Apoptotic Process Fatty-acyl-CoA Biosynthetic Process Anatomical Structure Regression Positive Regulation Of Protein Oligomerization Cell Activation Hepatocyte Apoptotic Process Macrophage Differentiation Sulfation Regulation Of DNA Methylation Negative Regulation Of Histone Acetylation Immune System Development Thymic T Cell Selection Acetyl-CoA Metabolic Process Long-chain Fatty-acyl-CoA Metabolic Process Negative Regulation Of Peptidyl-lysine Acetylation Steroid Catabolic Process Negative Regulation Of Protein Acetylation Apoptotic Process Involved In Morphogenesis Myeloid Dendritic Cell Differentiation Myeloid Dendritic Cell Activation	Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Aromatic Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Cell Differentiation Myeloid Cell Differentiation Cellular Metabolic Process Multicellular Organismal Development Regulation Of Cell Differentiation Hemopoiesis Developmental Process Immune System Development Myeloid Leukocyte Differentiation Immune System Process Regulation Of Immune System Process Regulation Of Chromosome Organization Anatomical Structure Development System Development Regulation Of Cellular Process
Tagcloud ?		calnexin calreticulin catalysed desirable disulphide erdj5 erp44 erp57 erp72 grp78 immunocytochemical immunogens immunolocalization infective isomerase orthologues pdi pdia10 pdia19 pdia2 pdia3 pdia4 pdis spiralis thioredoxin tmx2 tmx3 trichinella trimerization	alongside averaging bioinformatics conducting database degs downloaded encyclopedia enriched genomes glioblastoma gse4290 iongated kyoto ligandreceptor multichip neuroactive nontumor omnibus ontology raw sp1 subnets tf tfs transfac trimmed vesiclemediated zscores
Tagcloud (Difference) ?		calnexin calreticulin catalysed desirable disulphide erdj5 erp44 erp57 erp72 grp78 immunocytochemical immunogens immunolocalization infective isomerase orthologues pdi pdia10 pdia19 pdia2 pdia3 pdia4 pdis spiralis thioredoxin tmx2 tmx3 trichinella trimerization	alongside averaging bioinformatics conducting database degs downloaded encyclopedia enriched genomes glioblastoma gse4290 iongated kyoto ligandreceptor multichip neuroactive nontumor omnibus ontology raw sp1 subnets tf tfs transfac trimmed vesiclemediated zscores
Tagcloud (Intersection) ?