SPI1 and ATF1

Number of citations of the paper that reports this interaction (PMID 7730336)
13

Data Source:
HPRD (in vitro)

		SPI1	ATF1
Gene Name		Spi-1 proto-oncogene	activating transcription factor 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin	Nucleus Nucleoplasm ATF1-ATF4 Transcription Factor Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Core Promoter Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Transcription Factor Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity RNA Binding Protein Binding NFAT Protein Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Complex Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Lymphoid Progenitor Cell Differentiation Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Lymphocyte Differentiation Erythrocyte Differentiation Macrophage Differentiation Granulocyte Differentiation Somatic Stem Cell Maintenance Myeloid Dendritic Cell Differentiation Histone H3 Acetylation Hypermethylation Of CpG Island Negative Regulation Of MHC Class II Biosynthetic Process Regulation Of Erythrocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Regression Negative Regulation Of Histone H4 Acetylation Apoptotic Process Involved In Patterning Of Blood Vessels	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter Positive Regulation Of Neuron Projection Development Response To Organic Cyclic Compound Response To Cobalt Ion Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Cellular Protein Complex Assembly Innate Immune Response Positive Regulation Of DNA Replication Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Stress-activated MAPK Cascade
Pathways			CREB phosphorylation Toll Like Receptor 7/8 (TLR7/8) Cascade CREB phosphorylation Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Innate Immune System Signalling by NGF TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS			Colorectal cancer ( 20972440) Sudden cardiac arrest ( 21658281)
Protein-Protein Interactions		43 interactors: ATF1 BCL6 CEBPA CEBPB CEBPD CEBPE CREBBP CREM CSNK2A1 DNMT3A DNMT3B ERG ETS1 ETS2 ETV1 FOS FUS GATA1 GATA2 GATA3 GFI1 HDAC1 HOXA10 IRF1 IRF4 IRF8 JUN KAT6A MAPK8 MECP2 MITF NFATC1 NFKB1 NFYA NONO PIP RB1 SIN3A SKI SPIB SSRP1 TBP TMX1	20 interactors: BRCA1 CAMK1 CAMK2A CAMK2G CREB1 CREBBP CREM CSNK2A1 CSNK2A2 CSNK2B EDF1 GABPA GABPB1 HNF1B JUN PRKACA RPS6KA4 RPS6KA5 SPI1 SRA1
Entrez ID		6688	466
HPRD ID		01305	00440
Ensembl ID		ENSG00000066336	ENSG00000123268
Uniprot IDs		P17947	P18846
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Aromatic Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Cell Differentiation Myeloid Cell Differentiation Cellular Metabolic Process Multicellular Organismal Development Regulation Of Cell Differentiation Hemopoiesis Developmental Process Immune System Development Myeloid Leukocyte Differentiation Immune System Process Regulation Of Immune System Process Regulation Of Chromosome Organization Anatomical Structure Development System Development Regulation Of Cellular Process	Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Developmental Process Multicellular Organismal Development Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Chromosome Organization Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Anatomical Structure Development Protein Phosphorylation Negative Regulation Of Biosynthetic Process Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Regulation Of Histone Acetylation Phosphorylation Response To Cytokine RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Protein Modification Process Axon Development Regulation Of Myeloid Cell Differentiation Gene Expression Chemotaxis Positive Regulation Of Histone Acetylation Negative Regulation Of Gene Expression Nervous System Development Cell Development Cellular Macromolecule Biosynthetic Process Axon Guidance Apoptotic Process Positive Regulation Of Peptidyl-lysine Acetylation Negative Regulation Of Chromosome Organization Macromolecule Biosynthetic Process Positive Regulation Of Protein Acetylation Programmed Cell Death Anatomical Structure Morphogenesis
Tagcloud ?		alongside averaging bioinformatics conducting database degs downloaded encyclopedia enriched genomes glioblastoma gse4290 iongated kyoto ligandreceptor multichip neuroactive nontumor omnibus ontology raw sp1 subnets tf tfs transfac trimmed vesiclemediated zscores	cascades creb erk2 ester esters exclude fgf k1 k2 km mapk2 mapkap mc mirror msk1 ngf p90rsk pc12 phorbol phosphorylates pka polypeptide ro sapk2 sb ser133 sk suppresses unstimulated
Tagcloud (Difference) ?		alongside averaging bioinformatics conducting database degs downloaded encyclopedia enriched genomes glioblastoma gse4290 iongated kyoto ligandreceptor multichip neuroactive nontumor omnibus ontology raw sp1 subnets tf tfs transfac trimmed vesiclemediated zscores	cascades creb erk2 ester esters exclude fgf k1 k2 km mapk2 mapkap mc mirror msk1 ngf p90rsk pc12 phorbol phosphorylates pka polypeptide ro sapk2 sb ser133 sk suppresses unstimulated
Tagcloud (Intersection) ?