SPI1 and PIP

Number of citations of the paper that reports this interaction (PMID 11133986)
5

Data Source:
HPRD (in vivo, in vitro)

		SPI1	PIP
Gene Name		Spi-1 proto-oncogene	prolactin-induced protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin	Extracellular Space Nucleus Apical Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Core Promoter Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Transcription Factor Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity RNA Binding Protein Binding NFAT Protein Binding	Glycoprotein Binding Actin Binding Aspartic-type Endopeptidase Activity Protein Binding IgG Binding Protein Dimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Lymphoid Progenitor Cell Differentiation Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Lymphocyte Differentiation Erythrocyte Differentiation Macrophage Differentiation Granulocyte Differentiation Somatic Stem Cell Maintenance Myeloid Dendritic Cell Differentiation Histone H3 Acetylation Hypermethylation Of CpG Island Negative Regulation Of MHC Class II Biosynthetic Process Regulation Of Erythrocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Regression Negative Regulation Of Histone H4 Acetylation Apoptotic Process Involved In Patterning Of Blood Vessels	Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Retina Homeostasis Regulation Of Immune System Process Proteolysis Positive Regulation Of Gene Expression Negative Regulation Of T Cell Apoptotic Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		43 interactors: ATF1 BCL6 CEBPA CEBPB CEBPD CEBPE CREBBP CREM CSNK2A1 DNMT3A DNMT3B ERG ETS1 ETS2 ETV1 FOS FUS GATA1 GATA2 GATA3 GFI1 HDAC1 HOXA10 IRF1 IRF4 IRF8 JUN KAT6A MAPK8 MECP2 MITF NFATC1 NFKB1 NFYA NONO PIP RB1 SIN3A SKI SPIB SSRP1 TBP TMX1	2 interactors: CD4 SPI1
Entrez ID		6688	5304
HPRD ID		01305	07179
Ensembl ID		ENSG00000066336	ENSG00000159763
Uniprot IDs		P17947	P12273
PDB IDs			3ES6
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Aromatic Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Cell Differentiation Myeloid Cell Differentiation Cellular Metabolic Process Multicellular Organismal Development Regulation Of Cell Differentiation Hemopoiesis Developmental Process Immune System Development Myeloid Leukocyte Differentiation Immune System Process Regulation Of Immune System Process Regulation Of Chromosome Organization Anatomical Structure Development System Development Regulation Of Cellular Process	Induction By Virus Of Host Cell-cell Fusion Protein Palmitoleylation Lymphocyte Differentiation Leukocyte Differentiation Regulation Of Cellular Amino Acid Metabolic Process Lymphocyte Activation Hypermethylation Of CpG Island Leukocyte Activation Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of MHC Class II Biosynthetic Process Apoptotic Process Involved In Patterning Of Blood Vessels Hemopoiesis Negative Regulation Of Histone H4 Acetylation Cell Activation Immune System Development Lymphoid Progenitor Cell Differentiation Modulation By Virus Of Host Process Positive Regulation Of Interleukin-2 Biosynthetic Process Granulocyte Differentiation Regulation Of Histone H4 Acetylation Anatomical Structure Regression Macrophage Differentiation Regulation Of DNA Methylation Negative Regulation Of Histone Acetylation Modulation By Virus Of Host Morphology Or Physiology Negative Regulation Of Peptidyl-lysine Acetylation Negative Regulation Of Protein Acetylation Regulation Of Interleukin-2 Biosynthetic Process Apoptotic Process Involved In Morphogenesis Myeloid Dendritic Cell Differentiation Regulation Of Defense Response To Virus By Virus Positive Regulation Of Calcium-mediated Signaling Myeloid Dendritic Cell Activation Apoptotic Process Involved In Development Positive Regulation Of Interleukin-2 Production Defense Response To Gram-negative Bacterium Regulation Of Erythrocyte Differentiation Regulation Of Immune System Process Dendritic Cell Differentiation Developmental Programmed Cell Death T Cell Selection Regulation Of Calcium-mediated Signaling Entry Into Host Cell Histone H3 Acetylation Regulation Of Histone Acetylation Patterning Of Blood Vessels Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cytokine Biosynthetic Process Somatic Stem Cell Maintenance
Tagcloud ?		alongside averaging bioinformatics conducting database degs downloaded encyclopedia enriched genomes glioblastoma gse4290 iongated kyoto ligandreceptor multichip neuroactive nontumor omnibus ontology raw sp1 subnets tf tfs transfac trimmed vesiclemediated zscores	aggregating amidolytic behaved benzamidine bothrops cearensis chromatographies deae esterolytic ethylenediamine moojeni msp nan nitroanilide pge1 phenylmethylsulfonyl pipecolyl pmsf proteinases sbti sephacel sephadex tame tcti tetracetic torresea tosyl trasylol washed
Tagcloud (Difference) ?		alongside averaging bioinformatics conducting database degs downloaded encyclopedia enriched genomes glioblastoma gse4290 iongated kyoto ligandreceptor multichip neuroactive nontumor omnibus ontology raw sp1 subnets tf tfs transfac trimmed vesiclemediated zscores	aggregating amidolytic behaved benzamidine bothrops cearensis chromatographies deae esterolytic ethylenediamine moojeni msp nan nitroanilide pge1 phenylmethylsulfonyl pipecolyl pmsf proteinases sbti sephacel sephadex tame tcti tetracetic torresea tosyl trasylol washed
Tagcloud (Intersection) ?