TMX1 and FKBP8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid, proximity labelling technology)

		TMX1	FKBP8
Description		thioredoxin related transmembrane protein 1	FKBP prolyl isomerase 8
Image
GO Annotations	Cellular Component	Extracellular Region Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endomembrane System Membrane Mitochondrial Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site	Mitochondrion Mitochondrial Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Endomembrane System Membrane Mitochondrial Membrane Protein-containing Complex
	Molecular Function	Protein Disulfide Isomerase Activity Enzyme Inhibitor Activity Protein Binding Protein-disulfide Reductase Activity Disulfide Oxidoreductase Activity Isomerase Activity	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Calmodulin Binding Isomerase Activity Identical Protein Binding Protein Folding Chaperone Metal Ion Binding Disordered Domain Specific Binding
	Biological Process	Negative Regulation Of Triglyceride Biosynthetic Process Triglyceride Biosynthetic Process Response To Endoplasmic Reticulum Stress Regulation Of Calcium Ion Transport Negative Regulation Of Platelet Aggregation Positive Regulation Of ERAD Pathway	Cell Fate Specification Negative Regulation Of Protein Phosphorylation Protein Folding Apoptotic Process Signal Transduction Smoothened Signaling Pathway Dorsal/ventral Pattern Formation Regulation Of Gene Expression Dorsal/ventral Neural Tube Patterning Neural Tube Development BMP Signaling Pathway Regulation Of BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Multicellular Organism Growth Intracellular Signal Transduction Camera-type Eye Development Negative Regulation Of Apoptotic Process Neuron Fate Specification Regulation Of Macromolecule Metabolic Process Protein Localization To Mitochondrion Regulation Of Mitophagy
Pathways			Ub-specific processing proteases
Drugs
Diseases
GWAS		Cancer ( 29299148) Nonsyndromic cleft lip with or without cleft palate ( 28087736) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576)	Plasma parathyroid hormone levels ( 30134803) Urinary potassium excretion ( 31409800)
Interacting Genes		12 interacting genes: BCL2L2 CCR1 CDC42 FAS FKBP8 GET3 GIMAP1 GIMAP5 LHFPL5 PMP22 SPI1 SULT2A1	52 interacting genes: AQP6 ARHGEF5 ARL13B ATP13A2 BCL2 BCL2L1 BIK BNIPL CD79A CIDEB CLCN1 CXCR2 CYB561 CYBRD1 EBP EGFR ELOVL4 ERBB2 ERGIC3 FAM174A FGF14 GPR37 JAGN1 MAPK14 MTOR OGT PEX12 PLN PPP3CA PSMC1 PSMD2 RETREG3 RHBDD2 RHEB SCN3B SHANK3 SLC10A1 SLC10A6 SLC35A5 SLC35B1 SLC71A2 SMO TERF1 TMEM14B TMEM254 TMEM31 TMEM43 TMEM45B TMEM80 TMX1 VHL ZFPL1
Entrez ID		81542	23770
HPRD ID		15590	05327
Ensembl ID		ENSG00000139921	ENSG00000105701
Uniprot IDs		Q9H3N1	B2R8G6 Q14318
PDB IDs		1X5E	2AWG 2D9F 2F2D 2MF9 3EY6 5MGX
Enriched GO Terms of Interacting Partners?			Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Regulation Of Cellular Localization Mitochondrial Membrane Negative Regulation Of Catabolic Process Regulation Of Protein Localization Bcl-2 Family Protein Complex Protein Binding Transmembrane Transport Negative Regulation Of Autophagy Dendritic Cell Apoptotic Process Ascorbate Homeostasis Intracellular Signal Transduction Regulation Of Membrane Potential Transmembrane Monodehydroascorbate Reductase Activity Striated Muscle Cell Development Skeletal Muscle Fiber Development Bile Acid:sodium Symporter Activity Positive Regulation Of Growth Regulation Of Protein Catabolic Process BH3 Domain Binding Myotube Cell Development Regulation Of Establishment Of Protein Localization Muscle Cell Development Negative Regulation Of Calcium Ion Transmembrane Transport Intracellular Signaling Cassette Regulation Of TORC1 Signaling Channel Activity ERBB2-EGFR Signaling Pathway Cell Morphogenesis Autophagy Negative Regulation Of Dendritic Cell Apoptotic Process Positive Regulation Of Striated Muscle Cell Differentiation Oligodendrocyte Differentiation Monoatomic Ion Transport Regulation Of Myotube Differentiation Positive Regulation Of Establishment Of Protein Localization Negative Regulation Of Translational Initiation Pyrimidine Nucleotide-sugar Transmembrane Transport Regulation Of Growth Positive Regulation Of Translational Initiation Mononuclear Cell Proliferation Nucleotide-sugar Transmembrane Transport Negative Regulation Of Calcium Ion Transport Identical Protein Binding Proteasomal Protein Catabolic Process Proteasome Regulatory Particle, Base Subcomplex Proteasome Regulatory Particle Ciliary Membrane
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