TMX1 and FAS

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TMX1	FAS
Gene Name		thioredoxin-related transmembrane protein 1	Fas cell surface death receptor
Image
Gene Ontology Annotations	Cellular Component	Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Nucleus Cytoplasm Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Protein Disulfide Isomerase Activity Disulfide Oxidoreductase Activity	Signal Transducer Activity Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Kinase Binding Identical Protein Binding
	Biological Process	Protein Folding Response To Endoplasmic Reticulum Stress Cell Redox Homeostasis Oxidation-reduction Process	Immunoglobulin Production Renal System Process Protein Complex Assembly Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation-induced Cell Death Of T Cells Inflammatory Cell Apoptotic Process Transformed Cell Apoptotic Process Signal Transduction Circadian Rhythm Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Toxic Substance B Cell Mediated Immunity Positive Regulation Of Protein Homooligomerization Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Thymic T Cell Selection Regulation Of Lymphocyte Differentiation Regulation Of Myeloid Cell Differentiation Spleen Development Negative Regulation Of B Cell Activation Protein Homooligomerization Response To Glucocorticoid Cellular Response To Mechanical Stimulus Cellular Response To Lithium Ion Cellular Response To Hyperoxia Motor Neuron Apoptotic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Hepatocyte Apoptotic Process Necroptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Death Receptor Signalling FasL/ CD95L signaling Programmed Cell Death Extrinsic Pathway
Drugs
Diseases
GWAS			Atrioventricular conduction ( 21041692) Immunoglobulin A ( 20694011) Obesity-related traits ( 23251661)
Protein-Protein Interactions		3 interactors: FAS SPI1 SULT2A1	48 interactors: ANK3 APAF1 APOA5 ATP6V0B BAG6 BTK C14orf1 CALM1 CASP8 CASP8AP2 CCND3 CD47 CRMP1 DAXX EEF1A1 EGFR EZR FADD FAF1 FAF2 FAIM2 FASLG FBF1 FEM1B FYN GADD45A HIPK3 HNRNPC KRIT1 LCK LRIF1 MBD4 MET PDCD6 PRKCA PTPN13 PTPN6 RAP1A RIPK1 SUMO1 TCAP TMX1 TNFSF13 TRADD TRAF3 UBA7 UBE2I UBQLN1
Entrez ID		81542	355
HPRD ID		15590	00609
Ensembl ID			ENSG00000026103
Uniprot IDs		B4DZX7 Q9H3N1	P25445
PDB IDs		1X5E	1BZI 1DDF 3EWT 3EZQ 3THM 3TJE
Enriched GO Terms of Interacting Partners?		Regulation Of Myeloid Cell Differentiation Motor Neuron Apoptotic Process Lymphocyte Differentiation Homeostasis Of Number Of Cells Bile Acid Catabolic Process Hypermethylation Of CpG Island Leukocyte Differentiation Sulfur Compound Metabolic Process Necroptotic Signaling Pathway Negative Regulation Of MHC Class II Biosynthetic Process Transformed Cell Apoptotic Process Activation-induced Cell Death Of T Cells Lymphocyte Activation Apoptotic Process Involved In Patterning Of Blood Vessels Inflammatory Cell Apoptotic Process Cellular Response To Hyperoxia Negative Regulation Of Histone H4 Acetylation Positive Regulation Of Protein Homooligomerization Leukocyte Activation Lymphoid Progenitor Cell Differentiation Pantothenate Metabolic Process Monocarboxylic Acid Metabolic Process Negative Thymic T Cell Selection Negative T Cell Selection Long-chain Fatty-acyl-CoA Biosynthetic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Granulocyte Differentiation Hemopoiesis Regulation Of Histone H4 Acetylation Cellular Response To Lithium Ion T Cell Apoptotic Process Fatty-acyl-CoA Biosynthetic Process Anatomical Structure Regression Positive Regulation Of Protein Oligomerization Cell Activation Hepatocyte Apoptotic Process Macrophage Differentiation Sulfation Regulation Of DNA Methylation Negative Regulation Of Histone Acetylation Immune System Development Thymic T Cell Selection Acetyl-CoA Metabolic Process Long-chain Fatty-acyl-CoA Metabolic Process Negative Regulation Of Peptidyl-lysine Acetylation Steroid Catabolic Process Negative Regulation Of Protein Acetylation Apoptotic Process Involved In Morphogenesis Myeloid Dendritic Cell Differentiation Myeloid Dendritic Cell Activation	Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Cell Death Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Regulation Of Catalytic Activity Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Peptidase Activity Response To Stimulus Positive Regulation Of Catalytic Activity Regulation Of Signaling Regulation Of Metabolic Process Response To Stress Positive Regulation Of Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Proteolysis Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Protein Processing Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Signal Transduction Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway Innate Immune Response Regulation Of Proteolysis Positive Regulation Of Macrophage Differentiation Response To Mechanical Stimulus Positive Regulation Of Hydrolase Activity Signaling Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cell Communication Regulation Of Protein Kinase Activity Immune Response
Tagcloud ?		calnexin calreticulin catalysed desirable disulphide erdj5 erp44 erp57 erp72 grp78 immunocytochemical immunogens immunolocalization infective isomerase orthologues pdi pdia10 pdia19 pdia2 pdia3 pdia4 pdis spiralis thioredoxin tmx2 tmx3 trichinella trimerization	activities auto catalytically constitute constitutive constitutively construct constructs deleted ds dsrna egfp fusion green inactive inducible jellyfish pkr possess possessed protected serine stranded substitution sufficient threonine transfection tumorigenic visualize
Tagcloud (Difference) ?		calnexin calreticulin catalysed desirable disulphide erdj5 erp44 erp57 erp72 grp78 immunocytochemical immunogens immunolocalization infective isomerase orthologues pdi pdia10 pdia19 pdia2 pdia3 pdia4 pdis spiralis thioredoxin tmx2 tmx3 trichinella trimerization	activities auto catalytically constitute constitutive constitutively construct constructs deleted ds dsrna egfp fusion green inactive inducible jellyfish pkr possess possessed protected serine stranded substitution sufficient threonine transfection tumorigenic visualize
Tagcloud (Intersection) ?