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SPI1 and NFKB1
Number of citations of the paper that reports this interaction (PubMedID
9094628
)
107
Data Source:
HPRD
(in vitro)
SPI1
NFKB1
Description
Spi-1 proto-oncogene
nuclear factor kappa B subunit 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Chromatin
Extracellular Region
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Mitochondrion
Cytosol
I-kappaB/NF-kappaB Complex
Secretory Granule Lumen
NF-kappaB P50/p65 Complex
Specific Granule Lumen
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Activator Activity
DNA-binding Transcription Repressor Activity
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
RNA Binding
Protein Binding
Histone Deacetylase Binding
Sequence-specific DNA Binding
NFAT Protein Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
STAT Family Protein Binding
DNA-binding Transcription Factor Binding
Protein Sequestering Activity
Transcription Cis-regulatory Region Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Coactivator Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Transcription Coregulator Activity
Protein Binding
Identical Protein Binding
Actinin Binding
Sequence-specific DNA Binding
Protein Sequestering Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Vasculature Development
Germinal Center B Cell Differentiation
Follicular B Cell Differentiation
Lymphoid Progenitor Cell Differentiation
Immature B Cell Differentiation
Defense Response To Tumor Cell
Pro-T Cell Differentiation
Myeloid Leukocyte Differentiation
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Lymphocyte Differentiation
Cell Differentiation
Erythrocyte Differentiation
Macrophage Differentiation
Osteoclast Differentiation
Granulocyte Differentiation
Lipopolysaccharide-mediated Signaling Pathway
Somatic Stem Cell Population Maintenance
TRAIL-activated Apoptotic Signaling Pathway
Myeloid Dendritic Cell Differentiation
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Neutrophil Degranulation
Negative Regulation Of MHC Class II Biosynthetic Process
Response To Ethanol
Positive Regulation Of B Cell Differentiation
Regulation Of Erythrocyte Differentiation
Transcription Initiation-coupled Chromatin Remodeling
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Anatomical Structure Regression
Interleukin-6-mediated Signaling Pathway
Cellular Response To Ethanol
Oncogene-induced Cell Senescence
Endothelial To Hematopoietic Transition
Negative Regulation Of Protein Localization To Chromatin
Positive Regulation Of P38MAPK Cascade
Negative Regulation Of Non-canonical NF-kappaB Signal Transduction
Apoptotic Process Involved In Blood Vessel Morphogenesis
Positive Regulation Of MiRNA Transcription
Positive Regulation Of Microglial Cell Mediated Cytotoxicity
Negative Regulation Of Adipose Tissue Development
Pericyte Cell Differentiation
Positive Regulation Of Antifungal Innate Immune Response
Regulation Of Myeloid Progenitor Cell Differentiation
Positive Regulation Of Myeloid Dendritic Cell Chemotaxis
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
Negative Regulation Of Cytokine Production
Immune System Process
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Apoptotic Process
Inflammatory Response
Signal Transduction
Canonical NF-kappaB Signal Transduction
JNK Cascade
Gene Expression
Regulation Of Gene Expression
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Gene Expression
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Cholesterol Efflux
Positive Regulation Of Lipid Storage
Negative Regulation Of Vitamin D Biosynthetic Process
Signal Transduction Involved In Regulation Of Gene Expression
Negative Regulation Of Interleukin-12 Production
Tumor Necrosis Factor-mediated Signaling Pathway
Response To Muscle Stretch
Non-canonical NF-kappaB Signal Transduction
Negative Regulation Of Apoptotic Process
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Inflammatory Response
Positive Regulation Of Inflammatory Response
B Cell Receptor Signaling Pathway
Mammary Gland Involution
Positive Regulation Of Transcription Initiation By RNA Polymerase II
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Cellular Response To Nicotine
Cellular Response To Cytokine Stimulus
Cellular Response To Interleukin-6
Cellular Response To Tumor Necrosis Factor
Cellular Response To DsRNA
Positive Regulation Of Canonical Wnt Signaling Pathway
Cellular Response To Interleukin-17
Cellular Response To Virus
Antibacterial Innate Immune Response
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of Hyaluronan Biosynthetic Process
Cellular Response To Angiotensin
Positive Regulation Of MiRNA Metabolic Process
Pathways
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Transcriptional regulation of granulopoiesis
Transcriptional regulation of granulopoiesis
Activation of NF-kappaB in B cells
RIP-mediated NFkB activation via ZBP1
Regulated proteolysis of p75NTR
Downstream TCR signaling
NF-kB is activated and signals survival
Senescence-Associated Secretory Phenotype (SASP)
FCERI mediated NF-kB activation
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
PKMTs methylate histone lysines
Transcriptional regulation of white adipocyte differentiation
TAK1-dependent IKK and NF-kappa-B activation
Interleukin-1 processing
IkBA variant leads to EDA-ID
CLEC7A (Dectin-1) signaling
CD209 (DC-SIGN) signaling
CLEC7A/inflammasome pathway
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Neutrophil degranulation
The NLRP3 inflammasome
Transcriptional Regulation by VENTX
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
HCMV Early Events
Purinergic signaling in leishmaniasis infection
SARS-CoV-1 activates/modulates innate immune responses
Regulation of NFE2L2 gene expression
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Regulation of PD-L1(CD274) transcription
Drugs
Sulfasalazine
Donepezil
Pseudoephedrine
Pranlukast
Pranlukast
HE3286
P54
NOX-700
SGN-30
Custirsen
NF-kappaB Decoy
Andrographolide
Triflusal
Terpinen-4-ol
Glycyrrhizic acid
Fish oil
SC-236
Diseases
Acute myeloid leukemia (AML)
GWAS
Alcohol use disorder (total score) (
30336701
)
Alzheimer's disease or fasting glucose levels (pleiotropy) (
30805717
)
Apolipoprotein A1 levels (
32203549
)
Blood urea nitrogen levels (
31152163
)
Brain morphology (MOSTest) (
32665545
)
C-reactive protein levels (
30388399
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Estimated glomerular filtration rate (
31152163
)
Experiencing mood swings (
29500382
)
Familial squamous cell lung carcinoma (
29924316
)
Fruit consumption (
32066663
)
Global electrical heterogeneity phenotypes (
29622589
)
Hematocrit (
32888494
)
Hematology traits (
30576415
)
Hemoglobin (
32888494
)
Intraocular pressure (
29617998
25173106
)
Lacunar stroke (
33773637
)
Loneliness (
29970889
)
Loneliness (MTAG) (
29970889
)
Mean platelet volume (
32888494
)
Medication use (diuretics) (
31015401
)
Neuroticism (
29255261
)
Refractive error (
32231278
)
Albumin-globulin ratio (
29403010
)
Allergic disease (asthma, hay fever and/or eczema) (age of onset) (
32603359
)
Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) (
32603359
)
Allergic rhinitis (
30013184
)
Allergic sensitization (
30013184
)
Basophil percentage of white cells (
32888494
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Copper levels (
26025379
)
Creatinine levels (
29124443
)
Crohn's disease (
28067908
)
Eosinophil count (
27863252
32888494
)
Eosinophil percentage of granulocytes (
27863252
)
Eosinophil percentage of white cells (
27863252
32888494
)
Estimated glomerular filtration rate (
29124443
30604766
)
Glomerular filtration rate (creatinine) (
26831199
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Homeostasis model assessment of beta-cell function (dietary factor interaction) (
24204828
)
Immature fraction of reticulocytes (
32888494
)
Inflammatory bowel disease (
28067908
)
Lymphocyte count (
32888494
)
Lymphocyte percentage of white cells (
27863252
32888494
)
Mean corpuscular hemoglobin concentration (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Medication use (thyroid preparations) (
31015401
)
Membranous nephropathy (
32231244
)
Monocyte percentage of white cells (
27863252
)
Multiple sclerosis (
21833088
)
Neutrophil percentage of granulocytes (
27863252
)
Neutrophil percentage of white cells (
32888494
27863252
)
Non-albumin protein levels (
29403010
)
Primary biliary cholangitis (
28425483
23000144
26394269
28062665
21399635
30643196
)
Primary biliary cirrhosis (
22961000
)
Primary sclerosing cholangitis (
27992413
)
Refractive error (
32231278
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Schizophrenia (treatment resistant) (
22479419
)
Serum total protein levels (
29403010
)
Serum uric acid levels (
29124443
)
Sum eosinophil basophil counts (
27863252
)
Systemic sclerosis (
31672989
30247649
)
Tonsillectomy (
27182965
28928442
)
Ulcerative colitis (
23128233
)
White blood cell count (
32888494
)
Interacting Genes
47 interacting genes:
ATF1
BCL6
CEBPA
CEBPB
CEBPD
CEBPE
CREBBP
CREM
CSNK2A1
DNMT3A
DNMT3B
ERG
ETS1
ETS2
ETV1
FBXW7
FOS
FUS
GATA1
GATA2
GATA3
GFI1
GSK3B
HDAC1
HOXA10
IRF1
IRF2
IRF4
IRF8
JUN
KAT6A
MAPK8
MECP2
MITF
NFATC1
NFKB1
NFYA
NONO
PIP
RB1
RUNX1
SIN3A
SKI
SPIB
SSRP1
TBP
TMX1
106 interacting genes:
ABCC2
APBB2
AR
ATF3
BARD1
BCL3
BRCA1
BTRC
CDK9
CEBPB
CFLAR
CHUK
COPB2
COPS5
CTNNB1
DNMT3L
E2F1
ECSIT
ELF1
ELF3
ESR1
ETS1
FBXO7
FBXW11
FOS
G3BP2
GLUL
GSK3B
HDAC1
HMGA1
HMGA2
HMGB1
HSPA4
IKBKB
IKBKG
IL2RA
IRF1
IRF2
IRF8
IRF9
ITGB3BP
KAT5
KLF5
KPNA3
LYL1
MAP3K8
MEN1
MTPN
NCOA1
NCOA6
NCOR2
NFKB2
NFKBIA
NFKBIB
NFKBIE
NFKBIZ
NFRKB
NKRF
NOTCH1
NR3C1
NR4A1
PALS2
PARP1
PCBD1
PDCD11
PELP1
PLD3
PML
PPARG
PPP4C
PRKACA
PSMD10
REL
RELA
RELB
RGS14
RIPK1
RPS3
RSF1
RXRA
SERPINA3
SF1
SIN3A
SP1
SPAG9
SPI1
SPPL2A
SRF
STAT3
STAT6
TAB2
TFAP2A
TNFSF11
TNIP2
TP53BP1
TP53BP2
TRIP4
TSC22D3
TXN
UBE2D2
UBE2D3
UBE2K
UNC5CL
YWHAQ
YY1
ZBTB9
Entrez ID
6688
4790
HPRD ID
01305
01238
Ensembl ID
ENSG00000066336
ENSG00000109320
Uniprot IDs
A0AAA9YHK5
P17947
P19838
PDB IDs
8E3K
8E3R
8E4H
8E5Y
8EBH
8EE9
8EJ6
8EJ8
8EK3
8EK8
8EKJ
8EKU
8EKV
8EKZ
8EM9
8EMD
8ENG
8EO1
8EO4
8EQG
8EQK
8EQL
8T9U
8UFF
8UFK
8UFZ
8UHK
8V9N
8VDH
8VDI
1MDI
1MDJ
1MDK
1NFI
1SVC
2DBF
2O61
3GUT
7LEQ
7LET
7LF4
7LFC
7RG4
7RG5
8TQD
Enriched GO Terms of Interacting Partners
?
Regulation Of Transcription By RNA Polymerase II
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Positive Regulation Of Transcription By RNA Polymerase II
DNA Binding
Chromatin
Positive Regulation Of RNA Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Metabolic Process
Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
DNA-binding Transcription Factor Activity
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Gene Expression
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Metabolic Process
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Transcription Cis-regulatory Region Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Nucleoplasm
Regulation Of Metabolic Process
Sequence-specific Double-stranded DNA Binding
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleus
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Chromatin Binding
Negative Regulation Of Macromolecule Biosynthetic Process
Transcription Regulator Complex
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Myeloid Cell Differentiation
DNA-templated Transcription
Transcription By RNA Polymerase II
Cell Differentiation
Sequence-specific DNA Binding
Regulation Of Cell Development
Regulation Of Hemopoiesis
Regulation Of Cell Differentiation
Cellular Developmental Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Primary Metabolic Process
Regulation Of Gene Expression
Nucleoplasm
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Nucleus
Chromatin
Transcription Cis-regulatory Region Binding
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Response To Stress
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA Binding
Regulation Of Apoptotic Process
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Regulation Of Programmed Cell Death
Negative Regulation Of Transcription By RNA Polymerase II
DNA-binding Transcription Factor Activity
Intracellular Signal Transduction
Response To Cytokine
Response To Peptide
Sequence-specific DNA Binding
Regulation Of Intracellular Signal Transduction
Canonical NF-kappaB Signal Transduction
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Non-canonical NF-kappaB Signal Transduction
Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Developmental Process
Transcription Regulator Complex
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