SPI1 and NONO

Number of citations of the paper that reports this interaction (PubMedID 8626664)
0

Data Source:
BioGRID (pull down, affinity chromatography technology)
HPRD (in vitro, in vivo)

		SPI1	NONO
Description		Spi-1 proto-oncogene	non-POU domain containing octamer binding
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex	Fibrillar Center Nucleus Nucleoplasm Chromosome Nucleolus Membrane Nuclear Matrix Nuclear Speck Paraspeckles RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity DNA-binding Transcription Repressor Activity DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding Histone Deacetylase Binding Sequence-specific DNA Binding NFAT Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding STAT Family Protein Binding DNA-binding Transcription Factor Binding Protein Sequestering Activity	Nucleic Acid Binding DNA Binding Chromatin Binding RNA Binding Protein Binding Identical Protein Binding LncRNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Vasculature Development Germinal Center B Cell Differentiation Follicular B Cell Differentiation Lymphoid Progenitor Cell Differentiation Immature B Cell Differentiation Defense Response To Tumor Cell Pro-T Cell Differentiation Myeloid Leukocyte Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Lymphocyte Differentiation Cell Differentiation Erythrocyte Differentiation Macrophage Differentiation Osteoclast Differentiation Granulocyte Differentiation Lipopolysaccharide-mediated Signaling Pathway Somatic Stem Cell Population Maintenance TRAIL-activated Apoptotic Signaling Pathway Myeloid Dendritic Cell Differentiation Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Neutrophil Degranulation Negative Regulation Of MHC Class II Biosynthetic Process Response To Ethanol Positive Regulation Of B Cell Differentiation Regulation Of Erythrocyte Differentiation Transcription Initiation-coupled Chromatin Remodeling Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Regression Interleukin-6-mediated Signaling Pathway Cellular Response To Ethanol Oncogene-induced Cell Senescence Endothelial To Hematopoietic Transition Negative Regulation Of Protein Localization To Chromatin Positive Regulation Of P38MAPK Cascade Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Apoptotic Process Involved In Blood Vessel Morphogenesis Positive Regulation Of MiRNA Transcription Positive Regulation Of Microglial Cell Mediated Cytotoxicity Negative Regulation Of Adipose Tissue Development Pericyte Cell Differentiation Positive Regulation Of Antifungal Innate Immune Response Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Myeloid Dendritic Cell Chemotaxis	Activation Of Innate Immune Response Immune System Process DNA Repair DNA Recombination Regulation Of DNA-templated Transcription MRNA Processing DNA Damage Response Circadian Rhythm RNA Splicing Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Innate Immune Response Negative Regulation Of DNA-templated Transcription Rhythmic Process Cellular Response To Hypoxia Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Angiotensin
Pathways		RUNX1 regulates transcription of genes involved in differentiation of HSCs Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis
Drugs
Diseases		Acute myeloid leukemia (AML)
GWAS		Alcohol use disorder (total score) ( 30336701) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Blood urea nitrogen levels ( 31152163) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels ( 30388399) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Experiencing mood swings ( 29500382) Familial squamous cell lung carcinoma ( 29924316) Fruit consumption ( 32066663) Global electrical heterogeneity phenotypes ( 29622589) Hematocrit ( 32888494) Hematology traits ( 30576415) Hemoglobin ( 32888494) Intraocular pressure ( 29617998 25173106) Lacunar stroke ( 33773637) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Mean platelet volume ( 32888494) Medication use (diuretics) ( 31015401) Neuroticism ( 29255261) Refractive error ( 32231278)
Interacting Genes		47 interacting genes: ATF1 BCL6 CEBPA CEBPB CEBPD CEBPE CREBBP CREM CSNK2A1 DNMT3A DNMT3B ERG ETS1 ETS2 ETV1 FBXW7 FOS FUS GATA1 GATA2 GATA3 GFI1 GSK3B HDAC1 HOXA10 IRF1 IRF2 IRF4 IRF8 JUN KAT6A MAPK8 MECP2 MITF NFATC1 NFKB1 NFYA NONO PIP RB1 RUNX1 SIN3A SKI SPIB SSRP1 TBP TMX1	124 interacting genes: APBB1 AR BHLHE41 C11orf68 CA2 CDK1 CEBPA DANCR DDX6 DELEC1 ERCC6 ERG ESR1 EWSR1 FXR2 H3-4 IL7R IRAK3 LINC00624 LMO4 MAD1L1 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MYC MYCN OGT ORC5 OTUD5 PDE4B PIN1 PLEKHF2 POLR1H POLR2A PPP1CA PPP1CB PPP1CC PRKAA2 PRPF40A PSPC1 PTBP1 RNF8 SAMHD1 SFPQ SMARCB1 SMARCC1 SMARCD1 SPI1 SUMO2 SYNPO TAFAZZIN TCERG1 UBE2I USP11 WBP4
Entrez ID		6688	4841
HPRD ID		01305	02098
Ensembl ID		ENSG00000066336	ENSG00000147140
Uniprot IDs		A0AAA9YHK5 P17947	A0A0S2Z4Z9 Q15233
PDB IDs		8E3K 8E3R 8E4H 8E5Y 8EBH 8EE9 8EJ6 8EJ8 8EK3 8EK8 8EKJ 8EKU 8EKV 8EKZ 8EM9 8EMD 8ENG 8EO1 8EO4 8EQG 8EQK 8EQL 8T9U 8UFF 8UFK 8UFZ 8UHK 8V9N 8VDH 8VDI	3SDE 5IFM 6WMZ 7LRQ 7LRU 7PU5
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Transcription By RNA Polymerase II DNA Binding Chromatin Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Cis-regulatory Region Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleoplasm Regulation Of Metabolic Process Sequence-specific Double-stranded DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Chromatin Binding Negative Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Complex Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Myeloid Cell Differentiation DNA-templated Transcription Transcription By RNA Polymerase II Cell Differentiation Sequence-specific DNA Binding Regulation Of Cell Development Regulation Of Hemopoiesis Regulation Of Cell Differentiation Cellular Developmental Process	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Extracellular Vesicle Regulation Of Macromolecule Metabolic Process Negative Regulation Of Translation Regulation Of Metabolic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cytokine Production Negative Regulation Of Cell Motility Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Translation Negative Regulation Of Developmental Process Negative Regulation Of Cell Migration Negative Regulation Of Locomotion Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Signal Transduction Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Protein Metabolic Process Regulation Of Angiogenesis Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Vasculature Development Regulation Of MRNA Stability Regulation Of RNA Stability Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Developmental Process Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Blood Vessel Endothelial Cell Migration
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