SPI1 and CEBPA

Number of citations of the paper that reports this interaction (PMID 12091339)
24

Data Source:
HPRD (in vivo, in vitro)

		SPI1	CEBPA
Gene Name		Spi-1 proto-oncogene	CCAAT/enhancer binding protein (C/EBP), alpha
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin	Nucleus Nuclear Matrix Rb-E2F Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Core Promoter Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Transcription Factor Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity RNA Binding Protein Binding NFAT Protein Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Complex Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity HMG Box Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Lymphoid Progenitor Cell Differentiation Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Lymphocyte Differentiation Erythrocyte Differentiation Macrophage Differentiation Granulocyte Differentiation Somatic Stem Cell Maintenance Myeloid Dendritic Cell Differentiation Histone H3 Acetylation Hypermethylation Of CpG Island Negative Regulation Of MHC Class II Biosynthetic Process Regulation Of Erythrocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Regression Negative Regulation Of Histone H4 Acetylation Apoptotic Process Involved In Patterning Of Blood Vessels	Urea Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Liver Development Embryonic Placenta Development Generation Of Precursor Metabolites And Energy Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Acute-phase Response Mitochondrion Organization Cholesterol Metabolic Process Negative Regulation Of Cell Proliferation Viral Process Cytokine-mediated Signaling Pathway Myeloid Cell Differentiation Macrophage Differentiation Lung Development Organ Regeneration Response To Vitamin B2 Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase III Promoter Cell Maturation Inner Ear Development White Fat Cell Differentiation Brown Fat Cell Differentiation Response To Glucocorticoid Cellular Response To Lithium Ion Cellular Response To Organic Cyclic Compound
Pathways			Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS
Protein-Protein Interactions		43 interactors: ATF1 BCL6 CEBPA CEBPB CEBPD CEBPE CREBBP CREM CSNK2A1 DNMT3A DNMT3B ERG ETS1 ETS2 ETV1 FOS FUS GATA1 GATA2 GATA3 GFI1 HDAC1 HOXA10 IRF1 IRF4 IRF8 JUN KAT6A MAPK8 MECP2 MITF NFATC1 NFKB1 NFYA NONO PIP RB1 SIN3A SKI SPIB SSRP1 TBP TMX1	56 interactors: AR ATF2 ATF3 ATF4 ATF5 BATF BATF2 BATF3 C1QBP CDK2 CDK4 CDKN1A CDKN3 CDX1 CEBPB CEBPD CEBPE CEBPG CREBBP CTNNB1 DBP EDF1 EP300 ESR1 FOS FOSL1 GATA2 GSK3B HNF1A MAPK8 MSX2 MYC NCOA6 NFYA NR3C1 PIAS1 RARA RARB RASGRF1 RB1 RBL1 RFC1 RUNX1 SKP2 SMAD3 SMAD4 SMARCA2 SMARCA4 SOX10 SOX8 SPI1 SRA1 SUMO3 XRCC5 XRCC6 ZBTB16
Entrez ID		6688	1050
HPRD ID		01305	00296
Ensembl ID		ENSG00000066336	ENSG00000245848
Uniprot IDs		P17947	P49715
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Aromatic Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Cell Differentiation Myeloid Cell Differentiation Cellular Metabolic Process Multicellular Organismal Development Regulation Of Cell Differentiation Hemopoiesis Developmental Process Immune System Development Myeloid Leukocyte Differentiation Immune System Process Regulation Of Immune System Process Regulation Of Chromosome Organization Anatomical Structure Development System Development Regulation Of Cellular Process	Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Organ Development Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated System Development Multicellular Organismal Development Cellular Metabolic Process Anatomical Structure Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Developmental Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Cell Differentiation Regulation Of Cell Proliferation Regulation Of Cell Differentiation Tissue Development Myeloid Cell Differentiation Positive Regulation Of Cell Differentiation Regulation Of Cell Death Transcription Initiation From RNA Polymerase II Promoter
Tagcloud ?		alongside averaging bioinformatics conducting database degs downloaded encyclopedia enriched genomes glioblastoma gse4290 iongated kyoto ligandreceptor multichip neuroactive nontumor omnibus ontology raw sp1 subnets tf tfs transfac trimmed vesiclemediated zscores	acting additive c38 c40 caat cebpb collectively commitment composed concert elusive embryonic enhancer epidermis evolutionary fate keratinocyte keratinocytes layer modules p63 p63lre partly pluripotent pou pou3f1 redundant repress robust
Tagcloud (Difference) ?		alongside averaging bioinformatics conducting database degs downloaded encyclopedia enriched genomes glioblastoma gse4290 iongated kyoto ligandreceptor multichip neuroactive nontumor omnibus ontology raw sp1 subnets tf tfs transfac trimmed vesiclemediated zscores	acting additive c38 c40 caat cebpb collectively commitment composed concert elusive embryonic enhancer epidermis evolutionary fate keratinocyte keratinocytes layer modules p63 p63lre partly pluripotent pou pou3f1 redundant repress robust
Tagcloud (Intersection) ?