SPI1 and HOXA10

Number of citations of the paper that reports this interaction (PMID 18692240)
1

Data Source:
HPRD (in vitro, in vivo)

		SPI1	HOXA10
Gene Name		Spi-1 proto-oncogene	homeobox A10
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin	Nucleus Transcription Factor Complex Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Core Promoter Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Transcription Factor Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity RNA Binding Protein Binding NFAT Protein Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Protein Binding Histone Deacetylase Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Lymphoid Progenitor Cell Differentiation Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Lymphocyte Differentiation Erythrocyte Differentiation Macrophage Differentiation Granulocyte Differentiation Somatic Stem Cell Maintenance Myeloid Dendritic Cell Differentiation Histone H3 Acetylation Hypermethylation Of CpG Island Negative Regulation Of MHC Class II Biosynthetic Process Regulation Of Erythrocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Regression Negative Regulation Of Histone H4 Acetylation Apoptotic Process Involved In Patterning Of Blood Vessels	Skeletal System Development Transcription, DNA-templated Multicellular Organismal Development Spermatogenesis Single Fertilization Male Gonad Development Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Embryonic Limb Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Uterus Development
Pathways
Drugs
Diseases
GWAS			Dental caries ( 23259602)
Protein-Protein Interactions		43 interactors: ATF1 BCL6 CEBPA CEBPB CEBPD CEBPE CREBBP CREM CSNK2A1 DNMT3A DNMT3B ERG ETS1 ETS2 ETV1 FOS FUS GATA1 GATA2 GATA3 GFI1 HDAC1 HOXA10 IRF1 IRF4 IRF8 JUN KAT6A MAPK8 MECP2 MITF NFATC1 NFKB1 NFYA NONO PIP RB1 SIN3A SKI SPIB SSRP1 TBP TMX1	12 interactors: CREBBP EMX1 EP300 FOXO1 GMNN MEIS1 PBX1 POLR3D PTPN6 SIRT2 SNAPC1 SPI1
Entrez ID		6688	3206
HPRD ID		01305	00845
Ensembl ID		ENSG00000066336	ENSG00000253293
Uniprot IDs		P17947	P31260
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Aromatic Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Cell Differentiation Myeloid Cell Differentiation Cellular Metabolic Process Multicellular Organismal Development Regulation Of Cell Differentiation Hemopoiesis Developmental Process Immune System Development Myeloid Leukocyte Differentiation Immune System Process Regulation Of Immune System Process Regulation Of Chromosome Organization Anatomical Structure Development System Development Regulation Of Cellular Process	Immune System Process Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Cellular Response To Oxygen Levels Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Nitrogen Compound Metabolic Process Cell Development Protein Acetylation Negative Regulation Of Cell Differentiation N-terminal Peptidyl-lysine Acetylation Stem Cell Maintenance Positive Regulation Of Transcription, DNA-templated Innate Immune Response Organ Development Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Gene Expression Regulation Of Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Anatomical Structure Morphogenesis Gene Expression Multicellular Organismal Development Stem Cell Development Regulation Of Gene Expression Peptidyl-lysine Modification Cellular Macromolecule Biosynthetic Process Anatomical Structure Development Negative Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Positive Regulation Of Type I Interferon Production Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Stem Cell Differentiation N-terminal Protein Amino Acid Acetylation Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Immune Response Developmental Process Regulation Of Type I Interferon Production Negative Regulation Of Gene Expression System Development Defense Response
Tagcloud ?		alongside averaging bioinformatics conducting database degs downloaded encyclopedia enriched genomes glioblastoma gse4290 iongated kyoto ligandreceptor multichip neuroactive nontumor omnibus ontology raw sp1 subnets tf tfs transfac trimmed vesiclemediated zscores	contrary coordination definitive drives e2 elevate epigenetic eralpha ere ere1 ere2 eres extensively h3k4 haematopoiesis homeobox knockdown leukaemia lineage methylase mll mll1 much oestrogen recruiting start suppresses transcriptionally way
Tagcloud (Difference) ?		alongside averaging bioinformatics conducting database degs downloaded encyclopedia enriched genomes glioblastoma gse4290 iongated kyoto ligandreceptor multichip neuroactive nontumor omnibus ontology raw sp1 subnets tf tfs transfac trimmed vesiclemediated zscores	contrary coordination definitive drives e2 elevate epigenetic eralpha ere ere1 ere2 eres extensively h3k4 haematopoiesis homeobox knockdown leukaemia lineage methylase mll mll1 much oestrogen recruiting start suppresses transcriptionally way
Tagcloud (Intersection) ?