TMX1 and SULT2A1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		TMX1	SULT2A1
Description		thioredoxin related transmembrane protein 1	sulfotransferase family 2A member 1
Image
GO Annotations	Cellular Component	Extracellular Region Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endomembrane System Membrane Mitochondrial Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site	Cytoplasm Cytosol
	Molecular Function	Protein Disulfide Isomerase Activity Enzyme Inhibitor Activity Protein Binding Protein-disulfide Reductase Activity Disulfide Oxidoreductase Activity Isomerase Activity	Alcohol Sulfotransferase Activity Protein Binding Sulfotransferase Activity Transferase Activity Bile-salt Sulfotransferase Activity Steroid Sulfotransferase Activity 3'-phosphoadenosine 5'-phosphosulfate Binding
	Biological Process	Negative Regulation Of Triglyceride Biosynthetic Process Triglyceride Biosynthetic Process Response To Endoplasmic Reticulum Stress Regulation Of Calcium Ion Transport Negative Regulation Of Platelet Aggregation Positive Regulation Of ERAD Pathway	Ethanol Catabolic Process Lipid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Lipid Catabolic Process Bile Acid Catabolic Process Thyroid Hormone Metabolic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Sulfation
Pathways			Cytosolic sulfonation of small molecules PPARA activates gene expression Paracetamol ADME
Drugs			Adenosine 3',5'-diphosphate Aetiocholanolone Mercuric iodide
Diseases
GWAS		Cancer ( 29299148) Nonsyndromic cleft lip with or without cleft palate ( 28087736) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576)	Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) Cleft palate ( 30452639) Dehydroepiandrosterone sulphate levels ( 21533175) DHEAS levels ( 34748635) Estradiol levels ( 34255042) Gallstone disease ( 27094239 30504769) Liver enzyme levels (alkaline phosphatase) ( 33972514) Serum metabolite levels ( 23093944 33031748) Sex hormone levels ( 26014426) Triglyceride levels ( 32203549) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		12 interacting genes: BCL2L2 CCR1 CDC42 FAS FKBP8 GET3 GIMAP1 GIMAP5 LHFPL5 PMP22 SPI1 SULT2A1	6 interacting genes: NIF3L1 PRDX4 STAT3 STK3 SULT1B1 TMX1
Entrez ID		81542	6822
HPRD ID		15590	00502
Ensembl ID		ENSG00000139921	ENSG00000105398
Uniprot IDs		Q9H3N1	A8K015 Q06520
PDB IDs		1X5E	1EFH 1J99 1OV4 2QP3 2QP4 3F3Y 4IFB
Enriched GO Terms of Interacting Partners?			Uracil Binding Phosphate-containing Compound Metabolic Process Beta-alanine Metabolic Process Thymidine Catabolic Process Beta-alanine Biosynthetic Process Dihydropyrimidine Dehydrogenase (NADP+) Activity Regulation Of Developmental Growth Eating Behavior Regulation Of Multicellular Organism Growth Negative Regulation Of Multicellular Organismal Process Energy Homeostasis Response To Metformin Phosphorylation Pyrimidine Nucleoside Catabolic Process Thymine Metabolic Process Thymine Catabolic Process Uracil Catabolic Process Purine Nucleobase Catabolic Process Negative Regulation Of Primary MiRNA Processing Feeding Behavior Transforming Growth Factor Beta Receptor Signaling Pathway Protein Import Into Nucleus Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Skeletal Muscle Cell Proliferation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Developmental Growth I-kappaB Phosphorylation Negative Regulation Of Male Germ Cell Proliferation Import Into Nucleus CMP Catabolic Process DUMP Catabolic Process DCMP Catabolic Process UMP Catabolic Process RNA Sequestering Activity Regulation Of Growth Postsynapse To Nucleus Signaling Pathway Positive Regulation Of Small Molecule Metabolic Process T-helper 17 Type Immune Response Primitive Hemopoiesis Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Endocardium Development GDF15-GFRAL Signaling Pathway Thioredoxin-dependent Peroxiredoxin Activity Regulation Of Male Germ Cell Proliferation Negative Regulation Of Triglyceride Biosynthetic Process Deoxyribonucleoside Catabolic Process Negative Regulation Of Hydrogen Peroxide Metabolic Process Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Interleukin-23-mediated Signaling Pathway
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