TMX1 and SULT2A1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TMX1	SULT2A1
Gene Name		thioredoxin-related transmembrane protein 1	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
Image
Gene Ontology Annotations	Cellular Component	Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Cytosol
	Molecular Function	Protein Disulfide Isomerase Activity Disulfide Oxidoreductase Activity	Protein Binding Sulfotransferase Activity Bile-salt Sulfotransferase Activity
	Biological Process	Protein Folding Response To Endoplasmic Reticulum Stress Cell Redox Homeostasis Oxidation-reduction Process	Xenobiotic Metabolic Process Digestion Steroid Metabolic Process Bile Acid Catabolic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Sulfation
Pathways			PPARA activates gene expression Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Fatty acid, triacylglycerol, and ketone body metabolism Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Metabolism of lipids and lipoproteins Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Cytosolic sulfonation of small molecules Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs			Dehydroepiandrosterone Adenosine-3\'-5\'-Diphosphate Aetiocholanolone Mercury Diiodide
Diseases
GWAS			Dehydroepiandrosterone sulphate levels ( 21533175)
Protein-Protein Interactions		3 interactors: FAS SPI1 SULT2A1	5 interactors: PRDX4 STAT3 STK3 SULT1B1 TMX1
Entrez ID		81542	6822
HPRD ID		15590	00502
Ensembl ID			ENSG00000105398
Uniprot IDs		B4DZX7 Q9H3N1	A8K015 Q06520
PDB IDs		1X5E	1EFH 1J99 1OV4 2QP3 2QP4 3F3Y 4IFB
Enriched GO Terms of Interacting Partners?		Regulation Of Myeloid Cell Differentiation Motor Neuron Apoptotic Process Lymphocyte Differentiation Homeostasis Of Number Of Cells Bile Acid Catabolic Process Hypermethylation Of CpG Island Leukocyte Differentiation Sulfur Compound Metabolic Process Necroptotic Signaling Pathway Negative Regulation Of MHC Class II Biosynthetic Process Transformed Cell Apoptotic Process Activation-induced Cell Death Of T Cells Lymphocyte Activation Apoptotic Process Involved In Patterning Of Blood Vessels Inflammatory Cell Apoptotic Process Cellular Response To Hyperoxia Negative Regulation Of Histone H4 Acetylation Positive Regulation Of Protein Homooligomerization Leukocyte Activation Lymphoid Progenitor Cell Differentiation Pantothenate Metabolic Process Monocarboxylic Acid Metabolic Process Negative Thymic T Cell Selection Negative T Cell Selection Long-chain Fatty-acyl-CoA Biosynthetic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Granulocyte Differentiation Hemopoiesis Regulation Of Histone H4 Acetylation Cellular Response To Lithium Ion T Cell Apoptotic Process Fatty-acyl-CoA Biosynthetic Process Anatomical Structure Regression Positive Regulation Of Protein Oligomerization Cell Activation Hepatocyte Apoptotic Process Macrophage Differentiation Sulfation Regulation Of DNA Methylation Negative Regulation Of Histone Acetylation Immune System Development Thymic T Cell Selection Acetyl-CoA Metabolic Process Long-chain Fatty-acyl-CoA Metabolic Process Negative Regulation Of Peptidyl-lysine Acetylation Steroid Catabolic Process Negative Regulation Of Protein Acetylation Apoptotic Process Involved In Morphogenesis Myeloid Dendritic Cell Differentiation Myeloid Dendritic Cell Activation	Negative Regulation Of Male Germ Cell Proliferation Negative Regulation Of Cell Proliferation Cell Redox Homeostasis Regulation Of Male Germ Cell Proliferation Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Negative Regulation Of Cellular Component Movement Phosphate-containing Compound Metabolic Process Negative Regulation Of Locomotion Cellular Modified Amino Acid Metabolic Process Regulation Of Developmental Growth Protein Folding Reproductive Process Negative Regulation Of Glycolytic Process Cellular Response To Stimulus Homeostatic Process Primitive Hemopoiesis Radial Glial Cell Differentiation Regulation Of Cell Proliferation Protein Maturation By Protein Folding Interleukin-6-mediated Signaling Pathway I-kappaB Phosphorylation 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Regulation Of Axon Regeneration Endocardium Development Hepatocyte Apoptotic Process Sulfation Reproductive Structure Development Phosphorylation Intracellular Signal Transduction Reproductive System Development 4-hydroxyproline Metabolic Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Response To Stimulus Growth Hormone Receptor Signaling Pathway Temperature Homeostasis Flavonoid Metabolic Process Cellular Response To Growth Hormone Stimulus Cellular Response To Interleukin-6 Regulation Of Glycolytic Process Positive Regulation Of Notch Signaling Pathway Thyroid Hormone Metabolic Process Regulation Of Cell Migration Hippo Signaling Eating Behavior Negative Regulation Of Neuron Migration Regulation Of Growth Regulation Of Cell Motility
Tagcloud ?		calnexin calreticulin catalysed desirable disulphide erdj5 erp44 erp57 erp72 grp78 immunocytochemical immunogens immunolocalization infective isomerase orthologues pdi pdia10 pdia19 pdia2 pdia3 pdia4 pdis spiralis thioredoxin tmx2 tmx3 trichinella trimerization	23h1 aberrations birc5 ccne2 ctsb dab2 ddx15 dismal egr1 etv4 eya4 gata3 gltscr2 hmmr itgb4 kcnk12 lama3 licam2 loxl2 metastasize mmp13 mpnst mpnsts msh2 pdgfra rassf2 rhamm tff top2a
Tagcloud (Difference) ?		calnexin calreticulin catalysed desirable disulphide erdj5 erp44 erp57 erp72 grp78 immunocytochemical immunogens immunolocalization infective isomerase orthologues pdi pdia10 pdia19 pdia2 pdia3 pdia4 pdis spiralis thioredoxin tmx2 tmx3 trichinella trimerization	23h1 aberrations birc5 ccne2 ctsb dab2 ddx15 dismal egr1 etv4 eya4 gata3 gltscr2 hmmr itgb4 kcnk12 lama3 licam2 loxl2 metastasize mmp13 mpnst mpnsts msh2 pdgfra rassf2 rhamm tff top2a
Tagcloud (Intersection) ?