SPI1 and TMX1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SPI1	TMX1
Description		Spi-1 proto-oncogene	thioredoxin related transmembrane protein 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex	Extracellular Region Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endomembrane System Membrane Mitochondrial Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity DNA-binding Transcription Repressor Activity DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding Histone Deacetylase Binding Sequence-specific DNA Binding NFAT Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding STAT Family Protein Binding DNA-binding Transcription Factor Binding Protein Sequestering Activity	Protein Disulfide Isomerase Activity Enzyme Inhibitor Activity Protein Binding Protein-disulfide Reductase Activity Disulfide Oxidoreductase Activity Isomerase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Vasculature Development Germinal Center B Cell Differentiation Follicular B Cell Differentiation Lymphoid Progenitor Cell Differentiation Immature B Cell Differentiation Defense Response To Tumor Cell Pro-T Cell Differentiation Myeloid Leukocyte Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Lymphocyte Differentiation Cell Differentiation Erythrocyte Differentiation Macrophage Differentiation Osteoclast Differentiation Granulocyte Differentiation Lipopolysaccharide-mediated Signaling Pathway Somatic Stem Cell Population Maintenance TRAIL-activated Apoptotic Signaling Pathway Myeloid Dendritic Cell Differentiation Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Neutrophil Degranulation Negative Regulation Of MHC Class II Biosynthetic Process Response To Ethanol Positive Regulation Of B Cell Differentiation Regulation Of Erythrocyte Differentiation Transcription Initiation-coupled Chromatin Remodeling Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Regression Interleukin-6-mediated Signaling Pathway Cellular Response To Ethanol Oncogene-induced Cell Senescence Endothelial To Hematopoietic Transition Negative Regulation Of Protein Localization To Chromatin Positive Regulation Of P38MAPK Cascade Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Apoptotic Process Involved In Blood Vessel Morphogenesis Positive Regulation Of MiRNA Transcription Positive Regulation Of Microglial Cell Mediated Cytotoxicity Negative Regulation Of Adipose Tissue Development Pericyte Cell Differentiation Positive Regulation Of Antifungal Innate Immune Response Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Myeloid Dendritic Cell Chemotaxis	Negative Regulation Of Triglyceride Biosynthetic Process Triglyceride Biosynthetic Process Response To Endoplasmic Reticulum Stress Regulation Of Calcium Ion Transport Negative Regulation Of Platelet Aggregation Positive Regulation Of ERAD Pathway
Pathways		RUNX1 regulates transcription of genes involved in differentiation of HSCs Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis
Drugs
Diseases		Acute myeloid leukemia (AML)
GWAS		Alcohol use disorder (total score) ( 30336701) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Blood urea nitrogen levels ( 31152163) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels ( 30388399) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Experiencing mood swings ( 29500382) Familial squamous cell lung carcinoma ( 29924316) Fruit consumption ( 32066663) Global electrical heterogeneity phenotypes ( 29622589) Hematocrit ( 32888494) Hematology traits ( 30576415) Hemoglobin ( 32888494) Intraocular pressure ( 29617998 25173106) Lacunar stroke ( 33773637) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Mean platelet volume ( 32888494) Medication use (diuretics) ( 31015401) Neuroticism ( 29255261) Refractive error ( 32231278)	Cancer ( 29299148) Nonsyndromic cleft lip with or without cleft palate ( 28087736) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576)
Interacting Genes		47 interacting genes: ATF1 BCL6 CEBPA CEBPB CEBPD CEBPE CREBBP CREM CSNK2A1 DNMT3A DNMT3B ERG ETS1 ETS2 ETV1 FBXW7 FOS FUS GATA1 GATA2 GATA3 GFI1 GSK3B HDAC1 HOXA10 IRF1 IRF2 IRF4 IRF8 JUN KAT6A MAPK8 MECP2 MITF NFATC1 NFKB1 NFYA NONO PIP RB1 RUNX1 SIN3A SKI SPIB SSRP1 TBP TMX1	12 interacting genes: BCL2L2 CCR1 CDC42 FAS FKBP8 GET3 GIMAP1 GIMAP5 LHFPL5 PMP22 SPI1 SULT2A1
Entrez ID		6688	81542
HPRD ID		01305	15590
Ensembl ID		ENSG00000066336	ENSG00000139921
Uniprot IDs		A0AAA9YHK5 P17947	Q9H3N1
PDB IDs		8E3K 8E3R 8E4H 8E5Y 8EBH 8EE9 8EJ6 8EJ8 8EK3 8EK8 8EKJ 8EKU 8EKV 8EKZ 8EM9 8EMD 8ENG 8EO1 8EO4 8EQG 8EQK 8EQL 8T9U 8UFF 8UFK 8UFZ 8UHK 8V9N 8VDH 8VDI	1X5E
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Transcription By RNA Polymerase II DNA Binding Chromatin Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Cis-regulatory Region Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleoplasm Regulation Of Metabolic Process Sequence-specific Double-stranded DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Chromatin Binding Negative Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Complex Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Myeloid Cell Differentiation DNA-templated Transcription Transcription By RNA Polymerase II Cell Differentiation Sequence-specific DNA Binding Regulation Of Cell Development Regulation Of Hemopoiesis Regulation Of Cell Differentiation Cellular Developmental Process
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