ILKAP and HGS

Number of citations of the paper that reports this interaction (PMID 19019082)
2

Data Source:
BioGRID (pull down)

		ILKAP	HGS
Gene Name		integrin-linked kinase-associated serine/threonine phosphatase	hepatocyte growth factor-regulated tyrosine kinase substrate
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Cytoplasm Endosome Early Endosome Cytosol Secretory Granule Early Endosome Membrane Multivesicular Body Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding Metal Ion Binding	Protein Binding Protein Domain Specific Binding Metal Ion Binding
	Biological Process	Protein Dephosphorylation Regulation Of Nuclear Cell Cycle DNA Replication	Protein Targeting To Lysosome Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Endosome To Lysosome Transport Membrane Invagination Positive Regulation Of Gene Expression Endosomal Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Catabolic Process Negative Regulation Of JAK-STAT Cascade Membrane Organization Protein Localization To Membrane Positive Regulation Of Exosomal Secretion
Pathways			Signaling by EGFR EGFR downregulation Endosomal Sorting Complex Required For Transport (ESCRT) Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer
Drugs
Diseases
GWAS		Phospholipid levels (plasma) ( 22359512)	Eye color traits ( 20463881)
Protein-Protein Interactions		2 interactors: HGS ILK	138 interactors: ABI2 ACLY AHCYL1 APC APLP2 APP ARFIP2 ARL6IP1 ATP1A1 ATP2A2 ATXN1L BCAS2 BEGAIN BRINP3 BSG CASK CBS CCDC103 CCDC114 CCDC33 CEP55 CEP57L1 CLTC CRMP1 CSTF2 CSTF2T CTTNBP2NL DAZAP2 DCTN2 DECR1 DGCR6 DLG4 EGFR EHMT2 EPS15 ESRRG EXOC7 EXOC8 GFAP GFI1B GGA2 GKAP1 HAP1 HNRNPDL HSPA8 IL2RB IL4R ILKAP ING5 INTS4 JAKMIP2 KRT15 KRT18 KRT19 KRT31 KRT38 KRT40 KRT6A LDOC1 LINC00265 LITAF LURAP1 LYST MAGEB4 MAP3K10 MAP3K7 MAPK1IP1L MARK4 MAT2A MED7 MEST MET MIF4GD MKNK1 MRFAP1L1 MTHFD1L NDC80 NEDD4 NEDD4L NF2 NMI NPAS2 NUP54 OSBPL5 P4HA3 PAK1 PEF1 PELP1 PFKM PIK3R1 PITX1 PLD3 POGZ PPP1R16A PPP1R7 PTCD3 RHOBTB3 RPS3A RSU1 SCAMP3 SCRN1 SF3B3 SMAD2 SMAD3 SMAD5 SNAP25 SNX1 SNX5 SNX7 STAM STAM2 STXBP1 SUMO1 SUN2 TADA2A TIMMDC1 TJP2 TMCC2 TOM1L1 TRAK1 TRAP1 TSG101 TUBB TUBB2A UBA1 UBA52 UBB UBC UBE2I UBE4B UBQLN1 UBQLN4 USHBP1 VMP1 VPS37A VPS37C VPS37D ZNF302
Entrez ID		80895	9146
HPRD ID		17147	05085
Ensembl ID		ENSG00000132323	ENSG00000185359
Uniprot IDs		F8SNU7 Q9H0C8	O14964
PDB IDs			2D3G 3F1I 3OBQ 3ZYQ 4AVX
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Cell Proliferation Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Protein Targeting To Lysosome Fibroblast Migration Extracellular Fibril Organization Protein Localization To Lysosome Negative Regulation Of Striated Muscle Cell Apoptotic Process Negative Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Myoblast Differentiation Membrane Invagination Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Targeting To Vacuole Negative Regulation Of JAK-STAT Cascade Establishment Of Protein Localization To Vacuole Establishment Or Maintenance Of Apical/basal Cell Polarity Endosome To Lysosome Transport Myelin Assembly Negative Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Dendrite Morphogenesis Platelet Aggregation Protein Kinase B Signaling Positive Regulation Of Axon Extension Regulation Of Myoblast Differentiation Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Smooth Muscle Cell Proliferation Lysosomal Transport Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Myelination In Peripheral Nervous System Regulation Of Cell Proliferation Negative Regulation Of ERBB Signaling Pathway Schwann Cell Development Negative Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Cell-matrix Adhesion Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Dendrite Development Positive Regulation Of Exocytosis Branching Involved In Ureteric Bud Morphogenesis Schwann Cell Differentiation Regulation Of Intracellular Signal Transduction Ureteric Bud Morphogenesis Regulation Of Axon Extension Regulation Of Dendrite Morphogenesis Cell Aging Positive Regulation Of Osteoblast Differentiation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway	Establishment Of Localization In Cell Cellular Localization Viral Protein Processing Protein Localization Intracellular Transport Membrane Organization Endosomal Transport Establishment Of Protein Localization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Protein Transport Regulation Of ERBB Signaling Pathway Virion Assembly Intracellular Transport Of Virus Viral Process Cellular Protein Localization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Vesicle-mediated Transport Viral Life Cycle Cell Cycle Process Organelle Organization Negative Regulation Of Cellular Response To Growth Factor Stimulus Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Mitotic Cell Cycle Mitotic Cell Cycle Process Transport Post-Golgi Vesicle-mediated Transport Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Metabolic Process Gene Expression Cell Cycle Vesicle Organization Secretion By Cell Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Intracellular Protein Transport Transcription Initiation From RNA Polymerase II Promoter Cellular Process Cellular Response To Transforming Growth Factor Beta Stimulus Posttranscriptional Regulation Of Gene Expression Secretion Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Response To Transforming Growth Factor Beta Regulation Of Protein Catabolic Process JNK Cascade Response To Organic Substance
Tagcloud ?		2c alpha1 alpha3 alpha5 arg belongs cytoplasm deleted distributed far ilk1 importin integrin interacting interacts localize lys negatively nls phosphatase phosphorylating pp2c regulates researchers ribosomal rsk2 s6 tagged threonine	adjustments associates confounders continued cubic cv geriatric gnri handgrip hemodialysis hospitalization hospitalizations malnutrition mhd mis nutritional observational outpatients qol scales sf sf36 spline sua tertile trends upcoming uric y
Tagcloud (Difference) ?		2c alpha1 alpha3 alpha5 arg belongs cytoplasm deleted distributed far ilk1 importin integrin interacting interacts localize lys negatively nls phosphatase phosphorylating pp2c regulates researchers ribosomal rsk2 s6 tagged threonine	adjustments associates confounders continued cubic cv geriatric gnri handgrip hemodialysis hospitalization hospitalizations malnutrition mhd mis nutritional observational outpatients qol scales sf sf36 spline sua tertile trends upcoming uric y
Tagcloud (Intersection) ?