ILKAP and AATK

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		ILKAP	AATK
Description		ILK associated serine/threonine phosphatase	apoptosis associated tyrosine kinase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Cytoplasm Endomembrane System Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Cation Binding Metal Ion Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Signal Transduction	Brain Development Neuron Apoptotic Process
Pathways
Drugs
Diseases
GWAS		Hemoglobin levels ( 32327693) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Phospholipid levels (plasma) ( 22359512) Red cell distribution width ( 27863252)	Age at first sexual intercourse ( 34211149) Appendicular lean mass ( 33097823) Beef consumption ( 32066663) Lymphocyte percentage of white cells ( 32888494) Neuroticism ( 29255261) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Serum uric acid levels in response to allopurinol in gout ( 25676789)
Interacting Genes		24 interacting genes: AATK CHEK1 CNKSR1 EGFR EPHA2 EPHA3 ERBB2 ERBB3 ERBB4 FBXO7 HGS IGF1R ILK KDR KIT LMTK2 MAPK14 MUSK OGT PTK7 ROR1 ROR2 RPS6KA3 TEK	41 interacting genes: BDKRB2 CDC14A CDC25B CDK5 DUSP1 DUSP14 DUSP29 DUSP5 DUSP6 DUSP9 ERBB2 EYA2 EYA4 ILKAP MTMR10 MTMR6 MTMR8 MTMR9 PPM1A PPM1B PPM1F PPM1K PPM1M PPP1CA PPP3CA PPP3CB PTEN PTPDC1 PTPN11 PTPN12 PTPN18 PTPN20 PTPN6 PTPN7 PTPRR SBF1 STK39 STYX TAB1 TEPSIN TPTE2
Entrez ID		80895	9625
HPRD ID		17147	05591
Ensembl ID		ENSG00000132323	ENSG00000181409
Uniprot IDs		Q9H0C8	H7C175 Q6ZMQ8
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Kinase Activity ATP Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Receptor Complex Enzyme-linked Receptor Protein Signaling Pathway Nucleotide Binding Transferase Activity Cell Surface Receptor Signaling Pathway Signal Transduction Regulation Of Intracellular Signal Transduction Growth Factor Binding Regulation Of Developmental Process Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Signal Transduction Protein Phosphorylation Coreceptor Activity ERBB2 Signaling Pathway Basal Plasma Membrane Phosphorylation Regulation Of Locomotion Regulation Of Cellular Component Organization Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial Cell Proliferation Cell Population Proliferation Regulation Of Cell Migration Positive Regulation Of Signal Transduction Regulation Of Cell Motility Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Cellular Developmental Process Regulation Of Phosphorus Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Protein Autophosphorylation Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Animal Organ Development Positive Regulation Of Phosphorylation	Phosphoprotein Phosphatase Activity Dephosphorylation Protein Dephosphorylation Protein Tyrosine Phosphatase Activity Protein Serine/threonine Phosphatase Activity Hydrolase Activity Phosphate-containing Compound Metabolic Process Protein Tyrosine/serine/threonine Phosphatase Activity Protein Modification Process Peptidyl-tyrosine Dephosphorylation Non-membrane Spanning Protein Tyrosine Phosphatase Activity Cytoplasm MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Calmodulin-dependent Protein Phosphatase Activity Cation Binding Negative Regulation Of Signaling Regulation Of Signal Transduction Cytosol Regulation Of Cell Communication Regulation Of Signaling Protein Metabolic Process Negative Regulation Of Cell Communication Regulation Of ERK1 And ERK2 Cascade Regulation Of MAPK Cascade Phosphatase Activity Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction Negative Regulation Of MAPK Cascade Phosphatidylinositol Dephosphorylation Negative Regulation Of ERK1 And ERK2 Cascade Peptidyl-threonine Dephosphorylation Negative Regulation Of Intracellular Signal Transduction Phospholipid Dephosphorylation Macromolecule Metabolic Process Intracellular Signaling Cassette Phosphatidylinositol-3-phosphate Phosphatase Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Intracellular Signal Transduction ERK1 And ERK2 Cascade Manganese Ion Binding Cerebellar Cortex Formation Peptidyl-serine Dephosphorylation Phosphatidylinositol Metabolic Process Phosphatidylinositol-3,5-bisphosphate Phosphatase Activity MAPK Cascade N-terminal Protein Myristoylation ErbB-3 Class Receptor Binding Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Negative Regulation Of Transport Nucleoplasm
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