ILKAP and ILK

Number of citations of the paper that reports this interaction (PMID 11331582)
17

Data Source:
HPRD (in vivo, two hybrid)

		ILKAP	ILK
Gene Name		integrin-linked kinase-associated serine/threonine phosphatase	integrin-linked kinase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Stress Fiber Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Membrane Sarcomere Lamellipodium Cell Junction Neuronal Cell Body Costamere Terminal Bouton Dendritic Shaft Protein Complex
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding Metal Ion Binding	Protein Serine/threonine Kinase Activity Signal Transducer Activity Integrin Binding Protein Binding ATP Binding SH3 Domain Binding Protein Kinase Binding
	Biological Process	Protein Dephosphorylation Regulation Of Nuclear Cell Cycle DNA Replication	Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Cell-matrix Adhesion Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Cell Cycle Arrest Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell Aging Cell Proliferation Positive Regulation Of Cell Proliferation Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Fibroblast Migration Negative Regulation Of Smooth Muscle Cell Migration Peptidyl-serine Phosphorylation Nerve Development Myelination In Peripheral Nervous System Positive Regulation Of Cell Migration Positive Regulation Of BMP Signaling Pathway Myelin Assembly Regulation Of Actin Cytoskeleton Organization Cell Junction Assembly Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Phosphorylation Extracellular Fibril Organization Positive Regulation Of MAP Kinase Activity Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Myoblast Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Axon Extension Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Smooth Muscle Cell Proliferation Neuron Projection Morphogenesis Positive Regulation Of Dendrite Morphogenesis Protein Heterooligomerization Positive Regulation Of Protein Kinase B Signaling Platelet Aggregation Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Neural Precursor Cell Proliferation
Pathways			Cell junction organization Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Phospholipid levels (plasma) ( 22359512)
Protein-Protein Interactions		2 interactors: HGS ILK	35 interactors: AKT1 CASP8 CASP9 CAV1 CKB GSK3B ILKAP ITGB1 ITGB2 ITGB3 LIMS1 LIMS2 MIPEP NCK2 NOTCH1 PARVA PARVB PARVG PDPK1 PPP1R12A PXN RICTOR RNF19A RPL13 SERPINA4 SHC1 SNRNP35 TMSB4X TRIM27 TWF2 ZBTB48 ZNF133 ZNF205 ZNF579 ZNF746
Entrez ID		80895	3611
HPRD ID		17147	03842
Ensembl ID		ENSG00000132323	ENSG00000166333
Uniprot IDs		F8SNU7 Q9H0C8	B7Z1I0 B7Z418 Q13418
PDB IDs			2KBX 3F6Q 3IXE 3KMU 3KMW 3REP
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Cell Proliferation Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Protein Targeting To Lysosome Fibroblast Migration Extracellular Fibril Organization Protein Localization To Lysosome Negative Regulation Of Striated Muscle Cell Apoptotic Process Negative Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Myoblast Differentiation Membrane Invagination Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Targeting To Vacuole Negative Regulation Of JAK-STAT Cascade Establishment Of Protein Localization To Vacuole Establishment Or Maintenance Of Apical/basal Cell Polarity Endosome To Lysosome Transport Myelin Assembly Negative Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Dendrite Morphogenesis Platelet Aggregation Protein Kinase B Signaling Positive Regulation Of Axon Extension Regulation Of Myoblast Differentiation Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Smooth Muscle Cell Proliferation Lysosomal Transport Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Myelination In Peripheral Nervous System Regulation Of Cell Proliferation Negative Regulation Of ERBB Signaling Pathway Schwann Cell Development Negative Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Cell-matrix Adhesion Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Dendrite Development Positive Regulation Of Exocytosis Branching Involved In Ureteric Bud Morphogenesis Schwann Cell Differentiation Regulation Of Intracellular Signal Transduction Ureteric Bud Morphogenesis Regulation Of Axon Extension Regulation Of Dendrite Morphogenesis Cell Aging Positive Regulation Of Osteoblast Differentiation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway	Regulation Of Cellular Component Organization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Junction Assembly Cell-substrate Adhesion Response To Growth Factor Positive Regulation Of Signal Transduction Cell-matrix Adhesion Cytoskeleton Organization Regulation Of Cellular Amino Acid Metabolic Process Cell Adhesion Cellular Response To Growth Factor Stimulus Actin Cytoskeleton Organization Regulation Of Cell Adhesion Regulation Of Immune System Process Actin Filament-based Process Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Ketone Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Heterotypic Cell-cell Adhesion Regulation Of Cellular Protein Metabolic Process Actin Cytoskeleton Reorganization Single Organismal Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Blood Coagulation Wound Healing Fibroblast Growth Factor Receptor Signaling Pathway Hemostasis Regulation Of Phosphorylation Positive Regulation Of Cell Death Regulation Of Epithelial Cell Proliferation Cell Migration Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Signaling Pathway Regulation Of Immune Response Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Cell Morphogenesis Angiogenesis Response To Fibroblast Growth Factor Cell Motility Enzyme Linked Receptor Protein Signaling Pathway
Tagcloud ?		2c alpha1 alpha3 alpha5 arg belongs cytoplasm deleted distributed far ilk1 importin integrin interacting interacts localize lys negatively nls phosphatase phosphorylating pp2c regulates researchers ribosomal rsk2 s6 tagged threonine	bird cb11b cd18 chicks conferred eliminate enteritidis hatch heterophilic heterophils immaturity immunopotentiation initiates integrins kill lymphokines migrate phagocytic phagocytize phagocytosis posthatch poultry poults propria salmonella selectins turkey unfortunately vigorous
Tagcloud (Difference) ?		2c alpha1 alpha3 alpha5 arg belongs cytoplasm deleted distributed far ilk1 importin integrin interacting interacts localize lys negatively nls phosphatase phosphorylating pp2c regulates researchers ribosomal rsk2 s6 tagged threonine	bird cb11b cd18 chicks conferred eliminate enteritidis hatch heterophilic heterophils immaturity immunopotentiation initiates integrins kill lymphokines migrate phagocytic phagocytize phagocytosis posthatch poultry poults propria salmonella selectins turkey unfortunately vigorous
Tagcloud (Intersection) ?