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FXR1 and AXIN1
Number of citations of the paper that reports this interaction (PubMedID
21653829
)
54
Data Source:
BioGRID
(two hybrid)
FXR1
AXIN1
Description
FMR1 autosomal homolog 1
axin 1
Image
GO Annotations
Cellular Component
Nucleus
Nuclear Envelope
Nucleolus
Cytoplasm
Cytosol
Ribosome
Cytoplasmic Stress Granule
Membrane
Axon
Dendrite
Ribonucleoprotein Granule
Cytoplasmic Ribonucleoprotein Granule
Cell Projection
Neuron Projection
Costamere
Dendritic Spine
Intracellular Membraneless Organelle
Synapse
Perinuclear Region Of Cytoplasm
Presynapse
Postsynapse
Glutamatergic Synapse
Nucleus
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
Cell Cortex
Microtubule Cytoskeleton
Membrane
Lateral Plasma Membrane
Beta-catenin Destruction Complex
Cytoplasmic Vesicle
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Cell Periphery
Wnt Signalosome
Molecular Function
Nucleic Acid Binding
RNA Binding
MRNA Binding
MRNA 3'-UTR Binding
Protein Binding
RNA Strand Annealing Activity
MRNA 3'-UTR AU-rich Region Binding
Protein Homodimerization Activity
Ribonucleoprotein Complex Binding
Translation Regulator Activity
Protein Heterodimerization Activity
Molecular Condensate Scaffold Activity
P53 Binding
Protein Binding
Beta-catenin Binding
Enzyme Binding
Protein Kinase Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Signaling Adaptor Activity
Identical Protein Binding
Protein Homodimerization Activity
Protein Serine/threonine Kinase Activator Activity
SMAD Binding
Molecular Adaptor Activity
Armadillo Repeat Domain Binding
I-SMAD Binding
R-SMAD Binding
Protein Serine/threonine Kinase Binding
Ubiquitin-like Ligase-substrate Adaptor Activity
Biological Process
Cytoplasmic Translational Initiation
Regulation Of Translation
Apoptotic Process
Spermatogenesis
Spermatid Development
Muscle Organ Development
Post-transcriptional Regulation Of Gene Expression
Negative Regulation Of Translation
Dentate Gyrus Development
Cell Differentiation
Negative Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Rho Protein Signal Transduction
Regulation Of MRNA Stability
Regulation Of Circadian Sleep/wake Cycle, Sleep
Positive Regulation Of Translation
Positive Regulation Of Long-term Neuronal Synaptic Plasticity
Animal Organ Development
Negative Regulation Of Inflammatory Response
Regulation Of Neurogenesis
MRNA Transport
Nuclear Pore Complex Assembly
Nuclear Pore Localization
Regulation Of Synaptic Transmission, Glutamatergic
Skeletal Muscle Organ Development
Muscle Structure Development
MRNA Destabilization
Regulation Of Translation At Presynapse, Modulating Synaptic Transmission
Membraneless Organelle Assembly
Negative Regulation Of Long-term Synaptic Potentiation
Negative Regulation Of MRNA Catabolic Process
Positive Regulation Of MiRNA-mediated Gene Silencing
Protein Polyubiquitination
In Utero Embryonic Development
Nucleocytoplasmic Transport
Apoptotic Process
Sensory Perception Of Sound
Dorsal/ventral Axis Specification
Dorsal/ventral Pattern Formation
Negative Regulation Of Gene Expression
Wnt Signaling Pathway
Protein Catabolic Process
Negative Regulation Of Wnt Signaling Pathway
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Cytoplasmic Microtubule Organization
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Transcription Elongation By RNA Polymerase II
Post-anal Tail Morphogenesis
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Epigenetic Programming In The Zygotic Pronuclei
Negative Regulation Of Fat Cell Differentiation
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of JNK Cascade
Axial Mesoderm Development
Axial Mesoderm Formation
Cell Development
Negative Regulation Of Protein Metabolic Process
Canonical Wnt Signaling Pathway
Head Development
Regulation Of Canonical Wnt Signaling Pathway
Protein-containing Complex Assembly
Negative Regulation Of Canonical Wnt Signaling Pathway
Beta-catenin Destruction Complex Assembly
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways
Signaling by BRAF and RAF1 fusions
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
TCF dependent signaling in response to WNT
Degradation of AXIN
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
CTNNB1 S33 mutants aren't phosphorylated
CTNNB1 S37 mutants aren't phosphorylated
CTNNB1 S45 mutants aren't phosphorylated
CTNNB1 T41 mutants aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
Ub-specific processing proteases
RUNX1 regulates estrogen receptor mediated transcription
RUNX1 regulates transcription of genes involved in WNT signaling
Estrogen-dependent gene expression
Drugs
1,4-Dithiothreitol
Diseases
Caudal duplication anomaly
Hepatocellular carcinoma
GWAS
Bipolar disorder and eating disorder (
26433762
)
Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) (
31374203
)
Eating disorder in bipolar disorder (
26433762
)
Mastocytosis (
32752121
)
Metabolite levels (
23823483
)
Schizophrenia (
19571811
25056061
29483656
30285260
)
Adult body size (
32376654
)
Appendicular lean mass (
33097823
)
Body mass index (
25673413
)
Bone mineral density (spine) (
26733130
)
Femoral neck bone mineral density (
29499414
)
Heel bone mineral density (
30598549
28869591
)
Height (
31562340
)
Iron status biomarkers (ferritin levels) (
33536631
)
Lumbar spine bone mineral density (
29499414
22504420
)
Lumbar spine bone mineral density (integral) (
27476799
)
Lumbar spine bone mineral density (trabecular) (
27476799
)
Mean corpuscular hemoglobin (
27863252
32888494
)
Mean corpuscular hemoglobin concentration (
27863252
32888494
)
Mean corpuscular volume (
27863252
32888494
)
Metastatic colorectal cancer survival in treatment with chemotherapy plus biologics (
32958699
)
Red blood cell count (
27863252
)
Red cell distribution width (
27863252
)
Refractive error (
32231278
)
Systolic blood pressure (
31928498
)
Waist circumference (
31928498
)
Interacting Genes
254 interacting genes:
ABI1
ACLY
ACOT7
ACTB
ACTN1
ACTN2
ADAMTSL4
AHCY
ALAS1
ANKRD40
ANKS3
AP1M1
APC2
ARHGAP22
ARHGEF7
ATN1
AXIN1
AXIN2
BCKDK
BEND5
BHLHE40
BICD1
BLK
BLTP3B
BTBD2
BTBD6
BYSL
C1orf35
CA10
CACTIN-AS1
CALCOCO1
CAMK2A
CAMK2B
CAMK2G
CAPN3
CBS
CBX8
CCAR2
CCBE1
CCDC187
CCDC92
CCN3
CDC7
CDKL3
CDR2
CDYL
CEP126
CEP72
CEP89
CHRD
CIRSR
COIL
CORO1A
CORO1B
CORO6
CPLANE1
CRMP1
CSNK2A1
CSNK2B
CWF19L2
CYFIP2
DCTD
DCTN1
DCTN2
DCTPP1
DEAF1
DHX15
DNAJA3
DNM2
ECH1
ECHS1
ECM1
EDC4
EFEMP2
EGFL7
EIF3A
ELOA
ENO1
ERCC6
ERG28
ERVFRD-1
ESCO2
EVL
FAM161A
FAM90A1
FBLN1
FLAD1
FLNB
FMR1
FTH1
FXR2
GBP2
GFAP
GLYR1
GOLGA2
GOLGA3
GPSM2
GRIA2
GRIP1
GRIP2
GRIPAP1
HIVEP1
HLA-DRB5
HMG20A
HNRNPH2
HNRNPM
HNRNPUL1
HOMER2
HOMER3
HSPB1
IK
IMPDH2
INA
JAKMIP1
KAZN
KCNN1
KCTD1
KCTD13
KEAP1
KHDRBS1
KHDRBS3
KIAA1549L
KIF17
KIF9
KRT18
LAP3
LNX1
LRIF1
LRSAM1
LUC7L2
LZTS2
MAD1L1
MAGED1
MAGOH
MAGOHB
MAPK7
MAPK8IP3
MAPKBP1
MBIP
MCRS1
MFAP1
MLLT1
MOAP1
MSANTD3
MTUS2
MVP
MX1
MYH10
MYH9
MYO5B
N4BP3
NBPF15
NECAB2
NECAB3
NEFL
NEIL3
NKD2
NME1
NME1-NME2
NME3
PAFAH1B3
PAICS
PCCB
PCED1A
PDE9A
PHC1P1
PHC2
PHLDB1
PKM
PML
PNMA1
PPHLN1
PPP1R12C
PRAM1
PRKCSH
PRPF31
PRR13
PRSS23
PSMC3
PSMC5
PSME1
PSME3
PYCR1
PYCR2
PYCR3
RABAC1
RALYL
RBM26
RBM45
RPIA
RUSC2
SAFB2
SAMD1
SCMH1
SEPTIN2
SERTAD1
SF3B2
SFPQ
SH3GL2
SH3GLB2
SHANK1
SHARPIN
SLC48A1
SLIT1
SMN1
SNURF
SORBS3
SOX5
SPECC1
SPRY1
SPRY2
SRPK2
SSNA1
STK16
STUB1
SUFU
SYT6
TACC2
TASOR2
TBC1D22B
TCEA2
TDRD7
TLE5
TMPO
TNFAIP1
TRAF2
TRAP1
TRIM3
TRIOBP
TRPM1
TSN
TTLL5
TUBB
UBAP2L
UBP1
USP7
UXS1
VIM
VPS51
VWF
WASH6P
WEE2-AS1
WRNIP1
YAP1
YES1
YY1AP1
ZFTRAF1
ZMAT2
ZNF212
ZNF417
ZNF423
ZNF438
ZNF71
ZNF821
91 interacting genes:
AMER1
ANP32A
APC
BTRC
CALCOCO2
CARD9
CARM1
CCDC57
CDCA7L
CRMP1
CSNK1A1
CSNK1E
CTNNB1
DAB2
DIXDC1
DVL1
DVL2
DVL3
EEF1A1
ENTR1
ETV6
FXR1
FXR2
GAK
GMCL1
GNAS
GOLGA2
GSK3B
HOMEZ
JUP
KAT5
KRT40
KRTAP10-3
KRTAP4-12
KRTAP4-2
LHX4
LHX8
LMO2
LRP5
LRP6
MAP3K4
MDFI
MEOX2
MID2
MTUS2
MYC
MYOT
NBR1
NCK2
NUTM1
PIAS1
PML
PPP2CA
PPP2CB
PPP2R5B
PPP2R5C
PRMT1
PSTPIP1
RCHY1
RNF111
RUNX2
SCYL1
SENP2
SH3GL1
SIAH1
SMAD2
SMAD3
SMAD7
SMURF1
SMURF2
STX11
SUMO1
SUMO1P1
TFIP11
TNKS
TP53BP2
TRAF2
TRIM15
TRIM27
TRIM37
TRIM42
TRIP6
TSC1
TSGA10
UCHL5
USP10
USP7
UTP14A
WSB1
ZBTB26
ZFYVE19
Entrez ID
8087
8312
HPRD ID
02892
04819
Ensembl ID
ENSG00000114416
ENSG00000103126
Uniprot IDs
E7EU85
P51114
A0A0S2Z4R0
A0A0S2Z4S3
O15169
PDB IDs
2CPQ
3KUF
3O8V
1DK8
1EMU
1O9U
3ZDI
4B7T
4NM0
4NM3
4NM5
4NM7
4NU1
5WZZ
6JCK
7SXF
7SXG
7SXH
7SXJ
7Y1P
8RU3
8RU4
8VMG
Enriched GO Terms of Interacting Partners
?
Identical Protein Binding
Cytosol
Cytoplasm
Cytoskeleton
Protein Binding
Regulation Of Proteolysis
Cytoskeleton Organization
Postsynaptic Cytoskeleton Organization
Centrosome
Nucleoplasm
Protein Domain Specific Binding
Regulation Of Proteasomal Protein Catabolic Process
Symbiont-mediated Disruption Of Host Cell PML Body
Pyrroline-5-carboxylate Reductase Activity
Nucleus
Neuron Projection
Actin Filament
Organelle Organization
Synapse
Positive Regulation Of Proteolysis
Mitotic Spindle Pole
RNA Splicing, Via Transesterification Reactions
Calcium- And Calmodulin-dependent Protein Kinase Complex
Regulation Of Protein Metabolic Process
L-proline Biosynthetic Process
RNA Splicing
PcG Protein Complex
MRNA Processing
Stress Fiber
MRNA Splicing, Via Spliceosome
Microtubule Cytoskeleton Organization
Supramolecular Fiber Organization
Nervous System Development
Postsynaptic Actin Cytoskeleton Organization
Protein Homodimerization Activity
Regulation Of Ubiquitin-dependent Protein Catabolic Process
DNA Protection
Cell Cortex
U2-type Precatalytic Spliceosome
Bud Elongation Involved In Lung Branching
Glutamate Receptor Signaling Pathway
Structural Constituent Of Cytoskeleton
Postsynaptic Density
Microtubule Binding
Crotonyl-CoA Hydratase Activity
Uropod Organization
Protein Kinase Binding
RNA Binding
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
GTP Biosynthetic Process
Wnt Signaling Pathway
Cytoplasm
Cytosol
Positive Regulation Of Metabolic Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Signal Transduction
Canonical Wnt Signaling Pathway
Protein Modification By Small Protein Conjugation
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Catabolic Process
Regulation Of Wnt Signaling Pathway
Regulation Of Primary Metabolic Process
Positive Regulation Of Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Wnt Signalosome
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Post-translational Protein Modification
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Cellular Component Organization
Regulation Of Metabolic Process
Regulation Of Protein Metabolic Process
Protein Modification Process
Regulation Of Protein Catabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Cellular Component Organization
Modification-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Beta-catenin Destruction Complex
Signal Transduction
Beta-catenin Binding
PML Body
Positive Regulation Of Biosynthetic Process
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