FXR1 and SLC48A1

Number of citations: 54 (PubMedID 21653829)
Data Source: BioGRID (two hybrid)

		FXR1	SLC48A1
Name		FMR1 autosomal homolog 1	solute carrier family 48 member 1
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nucleolus Cytoplasm Cytosol Ribosome Cytoplasmic Stress Granule Membrane Axon Dendrite Ribonucleoprotein Granule Cytoplasmic Ribonucleoprotein Granule Cell Projection Neuron Projection Costamere Dendritic Spine Intracellular Membraneless Organelle Synapse Perinuclear Region Of Cytoplasm Presynapse Postsynapse Glutamatergic Synapse	Cytoplasm Lysosome Lysosomal Membrane Endosome Plasma Membrane Endosome Membrane Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Endolysosome Phagolysosome Membrane
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding RNA Strand Annealing Activity MRNA 3'-UTR AU-rich Region Binding Protein Homodimerization Activity Ribonucleoprotein Complex Binding Translation Regulator Activity Protein Heterodimerization Activity Molecular Condensate Scaffold Activity	Protein Binding Heme Transmembrane Transporter Activity Heme Binding
	Biological Process	Cytoplasmic Translational Initiation Regulation Of Translation Apoptotic Process Spermatogenesis Spermatid Development Muscle Organ Development Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Translation Dentate Gyrus Development Cell Differentiation Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Rho Protein Signal Transduction Regulation Of MRNA Stability Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Translation Positive Regulation Of Long-term Neuronal Synaptic Plasticity Animal Organ Development Negative Regulation Of Inflammatory Response Regulation Of Neurogenesis MRNA Transport Nuclear Pore Complex Assembly Nuclear Pore Localization Regulation Of Synaptic Transmission, Glutamatergic Skeletal Muscle Organ Development Muscle Structure Development MRNA Destabilization Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Membraneless Organelle Assembly Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of MRNA Catabolic Process Positive Regulation Of MiRNA-mediated Gene Silencing	Phagocytosis Lysosomal Transport Heme Transport Erythrocyte Differentiation Heme Metabolic Process Localization Of Cell Heme Export Heme Export From Vacuole To Cytoplasm
Pathways		Signaling by BRAF and RAF1 fusions	None
GWAS		Bipolar disorder and eating disorder ( 26433762 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Eating disorder in bipolar disorder ( 26433762 ) Mastocytosis ( 32752121 ) Metabolite levels ( 23823483 ) Schizophrenia ( 19571811 25056061 29483656 30285260 )	Asthma (adult onset) ( 31036433 ) Bipolar disorder ( 31043756 ) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Immature fraction of reticulocytes ( 32888494 )
Interacting Genes		254 interacting genes: ABI1 ACLY ACOT7 ACTB ACTN1 ACTN2 ADAMTSL4 AHCY ALAS1 ANKRD40 ANKS3 AP1M1 APC2 ARHGAP22 ARHGEF7 ATN1 AXIN1 AXIN2 BCKDK BEND5 BHLHE40 BICD1 BLK BLTP3B BTBD2 BTBD6 BYSL C1orf35 CA10 CACTIN-AS1 CALCOCO1 CAMK2A CAMK2B CAMK2G CAPN3 CBS CBX8 CCAR2 CCBE1 CCDC187 CCDC92 CCN3 CDC7 CDKL3 CDR2 CDYL CEP126 CEP72 CEP89 CHRD CIRSR COIL CORO1A CORO1B CORO6 CPLANE1 CRMP1 CSNK2A1 CSNK2B CWF19L2 CYFIP2 DCTD DCTN1 DCTN2 DCTPP1 DEAF1 DHX15 DNAJA3 DNM2 ECH1 ECHS1 ECM1 EDC4 EFEMP2 EGFL7 EIF3A ELOA ENO1 ERCC6 ERG28 ERVFRD-1 ESCO2 EVL FAM161A FAM90A1 FBLN1 FLAD1 FLNB FMR1 FTH1 FXR2 GBP2 GFAP GLYR1 GOLGA2 GOLGA3 GPSM2 GRIA2 GRIP1 GRIP2 GRIPAP1 HIVEP1 HLA-DRB5 HMG20A HNRNPH2 HNRNPM HNRNPUL1 HOMER2 HOMER3 HSPB1 IK IMPDH2 INA JAKMIP1 KAZN KCNN1 KCTD1 KCTD13 KEAP1 KHDRBS1 KHDRBS3 KIAA1549L KIF17 KIF9 KRT18 LAP3 LNX1 LRIF1 LRSAM1 LUC7L2 LZTS2 MAD1L1 MAGED1 MAGOH MAGOHB MAPK7 MAPK8IP3 MAPKBP1 MBIP MCRS1 MFAP1 MLLT1 MOAP1 MSANTD3 MTUS2 MVP MX1 MYH10 MYH9 MYO5B N4BP3 NBPF15 NECAB2 NECAB3 NEFL NEIL3 NKD2 NME1 NME1-NME2 NME3 PAFAH1B3 PAICS PCCB PCED1A PDE9A PHC1P1 PHC2 PHLDB1 PKM PML PNMA1 PPHLN1 PPP1R12C PRAM1 PRKCSH PRPF31 PRR13 PRSS23 PSMC3 PSMC5 PSME1 PSME3 PYCR1 PYCR2 PYCR3 RABAC1 RALYL RBM26 RBM45 RPIA RUSC2 SAFB2 SAMD1 SCMH1 SEPTIN2 SERTAD1 SF3B2 SFPQ SH3GL2 SH3GLB2 SHANK1 SHARPIN SLC48A1 SLIT1 SMN1 SNURF SORBS3 SOX5 SPECC1 SPRY1 SPRY2 SRPK2 SSNA1 STK16 STUB1 SUFU SYT6 TACC2 TASOR2 TBC1D22B TCEA2 TDRD7 TLE5 TMPO TNFAIP1 TRAF2 TRAP1 TRIM3 TRIOBP TRPM1 TSN TTLL5 TUBB UBAP2L UBP1 USP7 UXS1 VIM VPS51 VWF WASH6P WEE2-AS1 WRNIP1 YAP1 YES1 YY1AP1 ZFTRAF1 ZMAT2 ZNF212 ZNF417 ZNF423 ZNF438 ZNF71 ZNF821	9 interacting genes: APP COMT FXR1 LAMP1 LDAF1 MEOX2 SHANK3 TMEM14B UNC93A
Entrez ID		8087	55652
HPRD ID		02892	07916
Ensembl ID		ENSG00000114416	ENSG00000211584
Uniprot IDs		E7EU85 P51114	Q6P1K1
PDB IDs		2CPQ 3KUF 3O8V	Not available
GO Terms Enriched among Interactors		Identical Protein Binding Cytosol Cytoplasm Cytoskeleton Protein Binding Regulation Of Proteolysis Cytoskeleton Organization Postsynaptic Cytoskeleton Organization Centrosome Nucleoplasm Protein Domain Specific Binding Regulation Of Proteasomal Protein Catabolic Process Symbiont-mediated Disruption Of Host Cell PML Body Pyrroline-5-carboxylate Reductase Activity Nucleus Neuron Projection Actin Filament Organelle Organization Synapse Positive Regulation Of Proteolysis Mitotic Spindle Pole RNA Splicing, Via Transesterification Reactions Calcium- And Calmodulin-dependent Protein Kinase Complex Regulation Of Protein Metabolic Process L-proline Biosynthetic Process RNA Splicing PcG Protein Complex MRNA Processing Stress Fiber MRNA Splicing, Via Spliceosome Microtubule Cytoskeleton Organization Supramolecular Fiber Organization Nervous System Development Postsynaptic Actin Cytoskeleton Organization Protein Homodimerization Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process DNA Protection Cell Cortex U2-type Precatalytic Spliceosome Bud Elongation Involved In Lung Branching Glutamate Receptor Signaling Pathway Structural Constituent Of Cytoskeleton Postsynaptic Density Microtubule Binding Crotonyl-CoA Hydratase Activity Uropod Organization Protein Kinase Binding RNA Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process GTP Biosynthetic Process	Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Long-term Synaptic Potentiation Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Associative Learning Negative Regulation Of Long-term Synaptic Potentiation Memory Positive Regulation Of Long-term Synaptic Potentiation Learning Response To Catecholamine Dendritic Spine Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Synaptic Plasticity Neuron Projection Organization Modulation Of Excitatory Postsynaptic Potential Learning Or Memory Amyloid-beta Complex Growth Cone Lamellipodium Cognition Visual Behavior Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Visual Learning Norepinephrine Secretion Catechol O-methyltransferase Activity Neuron Projection Regulation Of Synaptic Transmission, Glutamatergic Synapse Acetylcholine Receptor Activator Activity Axon Lipoprotein Particle Positive Regulation Of Protein Import Cellular Response To Phosphate Starvation Guanylate Kinase-associated Protein Clustering PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Dendrite Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Neuromuscular Process Phagolysosome Membrane Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation