FXR1 and ZNF423

Number of citations of the paper that reports this interaction (PubMedID 21653829)
54

Data Source:
BioGRID (two hybrid)

		FXR1	ZNF423
Description		FMR1 autosomal homolog 1	zinc finger protein 423
Image
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nucleolus Cytoplasm Cytosol Ribosome Cytoplasmic Stress Granule Membrane Axon Dendrite Ribonucleoprotein Granule Cytoplasmic Ribonucleoprotein Granule Cell Projection Neuron Projection Costamere Dendritic Spine Intracellular Membraneless Organelle Synapse Perinuclear Region Of Cytoplasm Presynapse Postsynapse Glutamatergic Synapse	Nucleus Nucleoplasm
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding RNA Strand Annealing Activity MRNA 3'-UTR AU-rich Region Binding Protein Homodimerization Activity Ribonucleoprotein Complex Binding Translation Regulator Activity Protein Heterodimerization Activity Molecular Condensate Scaffold Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Cytoplasmic Translational Initiation Regulation Of Translation Apoptotic Process Spermatogenesis Spermatid Development Muscle Organ Development Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Translation Dentate Gyrus Development Cell Differentiation Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Rho Protein Signal Transduction Regulation Of MRNA Stability Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Translation Positive Regulation Of Long-term Neuronal Synaptic Plasticity Animal Organ Development Negative Regulation Of Inflammatory Response Regulation Of Neurogenesis MRNA Transport Nuclear Pore Complex Assembly Nuclear Pore Localization Regulation Of Synaptic Transmission, Glutamatergic Skeletal Muscle Organ Development Muscle Structure Development MRNA Destabilization Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Membraneless Organelle Assembly Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of MRNA Catabolic Process Positive Regulation Of MiRNA-mediated Gene Silencing	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Nervous System Development Cell Differentiation Positive Regulation Of BMP Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Protein Localization To Cilium Negative Regulation Of Cold-induced Thermogenesis
Pathways		Signaling by BRAF and RAF1 fusions	Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
Drugs
Diseases			Systemic lupus erythematosus
GWAS		Bipolar disorder and eating disorder ( 26433762) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Eating disorder in bipolar disorder ( 26433762) Mastocytosis ( 32752121) Metabolite levels ( 23823483) Schizophrenia ( 19571811 25056061 29483656 30285260)	A body shape index ( 34021172) Age at first sexual intercourse ( 34211149) Chronotype ( 30696823) Cold medicine-related Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) with severe ocular complications ( 28100913) Diastolic blood pressure ( 30224653) Heel bone mineral density ( 30598549) Inattentive symptoms ( 18821565) Mean spheric corpuscular volume ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Mosquito bite size ( 28199695) Neutrophil count ( 32888494) Number of sexual partners ( 30643258) Red blood cell count ( 32888494) Risk-taking tendency (4-domain principal component model) ( 30643258) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for body mass index ( 25673412) White blood cell count ( 32888494) Word spelling ( 30741946)
Interacting Genes		254 interacting genes: ABI1 ACLY ACOT7 ACTB ACTN1 ACTN2 ADAMTSL4 AHCY ALAS1 ANKRD40 ANKS3 AP1M1 APC2 ARHGAP22 ARHGEF7 ATN1 AXIN1 AXIN2 BCKDK BEND5 BHLHE40 BICD1 BLK BLTP3B BTBD2 BTBD6 BYSL C1orf35 CA10 CACTIN-AS1 CALCOCO1 CAMK2A CAMK2B CAMK2G CAPN3 CBS CBX8 CCAR2 CCBE1 CCDC187 CCDC92 CCN3 CDC7 CDKL3 CDR2 CDYL CEP126 CEP72 CEP89 CHRD CIRSR COIL CORO1A CORO1B CORO6 CPLANE1 CRMP1 CSNK2A1 CSNK2B CWF19L2 CYFIP2 DCTD DCTN1 DCTN2 DCTPP1 DEAF1 DHX15 DNAJA3 DNM2 ECH1 ECHS1 ECM1 EDC4 EFEMP2 EGFL7 EIF3A ELOA ENO1 ERCC6 ERG28 ERVFRD-1 ESCO2 EVL FAM161A FAM90A1 FBLN1 FLAD1 FLNB FMR1 FTH1 FXR2 GBP2 GFAP GLYR1 GOLGA2 GOLGA3 GPSM2 GRIA2 GRIP1 GRIP2 GRIPAP1 HIVEP1 HLA-DRB5 HMG20A HNRNPH2 HNRNPM HNRNPUL1 HOMER2 HOMER3 HSPB1 IK IMPDH2 INA JAKMIP1 KAZN KCNN1 KCTD1 KCTD13 KEAP1 KHDRBS1 KHDRBS3 KIAA1549L KIF17 KIF9 KRT18 LAP3 LNX1 LRIF1 LRSAM1 LUC7L2 LZTS2 MAD1L1 MAGED1 MAGOH MAGOHB MAPK7 MAPK8IP3 MAPKBP1 MBIP MCRS1 MFAP1 MLLT1 MOAP1 MSANTD3 MTUS2 MVP MX1 MYH10 MYH9 MYO5B N4BP3 NBPF15 NECAB2 NECAB3 NEFL NEIL3 NKD2 NME1 NME1-NME2 NME3 PAFAH1B3 PAICS PCCB PCED1A PDE9A PHC1P1 PHC2 PHLDB1 PKM PML PNMA1 PPHLN1 PPP1R12C PRAM1 PRKCSH PRPF31 PRR13 PRSS23 PSMC3 PSMC5 PSME1 PSME3 PYCR1 PYCR2 PYCR3 RABAC1 RALYL RBM26 RBM45 RPIA RUSC2 SAFB2 SAMD1 SCMH1 SEPTIN2 SERTAD1 SF3B2 SFPQ SH3GL2 SH3GLB2 SHANK1 SHARPIN SLC48A1 SLIT1 SMN1 SNURF SORBS3 SOX5 SPECC1 SPRY1 SPRY2 SRPK2 SSNA1 STK16 STUB1 SUFU SYT6 TACC2 TASOR2 TBC1D22B TCEA2 TDRD7 TLE5 TMPO TNFAIP1 TRAF2 TRAP1 TRIM3 TRIOBP TRPM1 TSN TTLL5 TUBB UBAP2L UBP1 USP7 UXS1 VIM VPS51 VWF WASH6P WEE2-AS1 WRNIP1 YAP1 YES1 YY1AP1 ZFTRAF1 ZMAT2 ZNF212 ZNF417 ZNF423 ZNF438 ZNF71 ZNF821	9 interacting genes: APP BRCA1 EBF1 FXR1 PARP1 SMAD1 SMAD4 TSC1 USP7
Entrez ID		8087	23090
HPRD ID		02892	05189
Ensembl ID		ENSG00000114416	ENSG00000102935
Uniprot IDs		E7EU85 P51114	A0A7P0Q1F0 B3KNG7 B7Z9C7 F5H7S1 Q2M1K9
PDB IDs		2CPQ 3KUF 3O8V	2MDG
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Cytosol Cytoplasm Cytoskeleton Protein Binding Regulation Of Proteolysis Cytoskeleton Organization Postsynaptic Cytoskeleton Organization Centrosome Nucleoplasm Protein Domain Specific Binding Regulation Of Proteasomal Protein Catabolic Process Symbiont-mediated Disruption Of Host Cell PML Body Pyrroline-5-carboxylate Reductase Activity Nucleus Neuron Projection Actin Filament Organelle Organization Synapse Positive Regulation Of Proteolysis Mitotic Spindle Pole RNA Splicing, Via Transesterification Reactions Calcium- And Calmodulin-dependent Protein Kinase Complex Regulation Of Protein Metabolic Process L-proline Biosynthetic Process RNA Splicing PcG Protein Complex MRNA Processing Stress Fiber MRNA Splicing, Via Spliceosome Microtubule Cytoskeleton Organization Supramolecular Fiber Organization Nervous System Development Postsynaptic Actin Cytoskeleton Organization Protein Homodimerization Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process DNA Protection Cell Cortex U2-type Precatalytic Spliceosome Bud Elongation Involved In Lung Branching Glutamate Receptor Signaling Pathway Structural Constituent Of Cytoskeleton Postsynaptic Density Microtubule Binding Crotonyl-CoA Hydratase Activity Uropod Organization Protein Kinase Binding RNA Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process GTP Biosynthetic Process	Protein-containing Complex Negative Regulation Of Catabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication SMAD Protein Complex Heteromeric SMAD Protein Complex Regulation Of MiRNA Transcription Cellular Response To Growth Factor Stimulus Negative Regulation Of Metabolic Process Regulation Of MiRNA Metabolic Process Regulation Of Circadian Rhythm Reproductive Process Regulation Of Signal Transduction Response To Growth Factor Negative Regulation Of Intracellular Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Small Molecule Metabolic Process Regulation Of Small Molecule Metabolic Process Positive Regulation Of Developmental Process Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation I-SMAD Binding Cardiac Conduction System Development Response To Stress Regulation Of Protein Catabolic Process Negative Regulation Of Protein Catabolic Process Regulation Of Apoptotic Signaling Pathway Nucleus Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Cell Differentiation Regulation Of RNA Metabolic Process Regulation Of Circadian Sleep/wake Cycle Regulation Of Cell Communication Regulation Of Signaling Regulation Of Primary Metabolic Process SMAD Protein Signal Transduction Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Cellular Component Organization R-SMAD Binding Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Macromolecule Metabolic Process Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process DNA Repair Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Gamete Generation Chromatin
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