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CUL5 and UBE2F
Number of citations of the paper that reports this interaction (PMID
23300442
)
7
Data Source:
BioGRID
(enzymatic study)
CUL5
UBE2F
Gene Name
cullin 5
ubiquitin-conjugating enzyme E2F (putative)
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Cytosol
Plasma Membrane
Cul5-RING Ubiquitin Ligase Complex
Cytoplasm
Molecular Function
Receptor Activity
Calcium Channel Activity
Protein Binding
Ubiquitin Protein Ligase Binding
Protein Heterodimerization Activity
Protein Binding
ATP Binding
Ligase Activity
NEDD8 Transferase Activity
Ubiquitin Protein Ligase Binding
Ubiquitin Protein Ligase Activity
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Ubiquitin-dependent Protein Catabolic Process
Response To Osmotic Stress
Cell Cycle Arrest
Cell Proliferation
Negative Regulation Of Cell Proliferation
Viral Process
Protein Ubiquitination
Cytosolic Calcium Ion Homeostasis
Calcium Ion Transmembrane Transport
Intrinsic Apoptotic Signaling Pathway
Protein Ubiquitination
Protein Neddylation
Pathways
Signaling by ERBB2
Vif-mediated degradation of APOBEC3G
Antigen processing: Ubiquitination & Proteasome degradation
HIV Infection
Host Interactions of HIV factors
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions
33 interactors:
ANAPC11
ARIH2
ASB11
CBFB
CCNDBP1
COMMD1
COPS2
COPS3
COPS4
COPS5
COPS6
COPS7A
COPS8
DCUN1D3
DCUN1D4
DCUN1D5
GOLGA2
GPS1
NEDD8
PRKACA
PTPN5
RBX1
RHOBTB1
RHOBTB2
RNF7
SMAD2
SMURF1
SOX30
TCEB1
TCEB2
TGFBR1
UBE2F
VHL
9 interactors:
CUL1
CUL5
DCUN1D1
DCUN1D2
NAE1
NEDD8
RNF34
RNF7
UBA3
Entrez ID
8065
140739
HPRD ID
03444
14812
Ensembl ID
ENSG00000166266
ENSG00000184182
Uniprot IDs
Q93034
C9J212
H9KVB9
Q969M7
PDB IDs
3DPL
3DQV
4JGH
2EDI
3FN1
4GBA
Enriched GO Terms of Interacting Partners
?
Cullin Deneddylation
Protein Deneddylation
Cellular Protein Modification Process
Protein Modification By Small Protein Removal
Cellular Protein Metabolic Process
Protein Neddylation
Protein Modification By Small Protein Conjugation
Protein Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Protein Ubiquitination
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Regulation Of DNA-templated Transcription In Response To Stress
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Protein Catabolic Process
Cellular Response To Oxygen Levels
Regulation Of Transcription From RNA Polymerase II Promoter
Transforming Growth Factor Beta Receptor Signaling Pathway
Cellular Metabolic Process
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Transforming Growth Factor Beta
Cellular Macromolecule Catabolic Process
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Transcription From RNA Polymerase II Promoter
Proteolysis
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Binding
Positive Regulation Of Cellular Metabolic Process
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Response To Cholesterol
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Response To Abiotic Stimulus
Intracellular Signal Transduction
Response To Hypoxia
Activin Receptor Signaling Pathway
Inactivation Of MAPK Activity
Cellular Response To Growth Factor Stimulus
Regulation Of Protein Binding
Positive Regulation Of Cellular Biosynthetic Process
Response To Growth Factor
Positive Regulation Of Dense Core Granule Biogenesis
Protein Polyubiquitination
Positive Regulation Of Viral Transcription
Peptidyl-threonine Phosphorylation
Negative Regulation Of Cell Proliferation
Protein Neddylation
Protein Modification By Small Protein Conjugation
Apoptotic Process
Cellular Protein Modification Process
Programmed Cell Death
Cell Death
Death
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Ubiquitination
Intrinsic Apoptotic Signaling Pathway
Protein Catabolic Process
Cellular Protein Metabolic Process
Proteolysis
Mitotic Cell Cycle
Cellular Macromolecule Catabolic Process
Regulation Of Cell Cycle
Apoptotic Signaling Pathway
Protein Metabolic Process
Negative Regulation Of Cell Cycle
Cell Cycle
Regulation Of Oxygen Metabolic Process
Endomitotic Cell Cycle
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Cell Cycle Arrest
Mitotic Cell Cycle Process
G1/S Transition Of Mitotic Cell Cycle
Cellular Response To Cold
Mitotic DNA Replication Checkpoint
Catabolic Process
Signal Transduction
Negative Regulation Of Execution Phase Of Apoptosis
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Signaling
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Cell Communication
DNA Replication Checkpoint
Cell Cycle Process
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Cell Cycle G2/M Phase Transition
Response To Redox State
Cellular Response To Stimulus
Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Signal Transduction By P53 Class Mediator
Regulation Of Execution Phase Of Apoptosis
Tagcloud
?
293te7
accumulated
adenovirus
cul2
cytoplasm
deleted
e1
e1b55k
e3
e4orf6
efficiently
export
exported
fastidiousness
hadv
heterotypic
homotypic
illustrate
indispensable
interacted
interacts
late
ligase
mre11
mrnas
reason
ubiquitin
versa
vice
Tagcloud (Difference)
?
293te7
accumulated
adenovirus
cul2
cytoplasm
deleted
e1
e1b55k
e3
e4orf6
efficiently
export
exported
fastidiousness
hadv
heterotypic
homotypic
illustrate
indispensable
interacted
interacts
late
ligase
mre11
mrnas
reason
ubiquitin
versa
vice
Tagcloud (Intersection)
?