CUL5 and CBFB

Number of citations of the paper that reports this interaction (PMID 24402281)
10

Data Source:
BioGRID (pull down, pull down)

		CUL5	CBFB
Gene Name		cullin 5	core-binding factor, beta subunit
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane Cul5-RING Ubiquitin Ligase Complex	Nucleus Membrane
	Molecular Function	Receptor Activity Calcium Channel Activity Protein Binding Ubiquitin Protein Ligase Binding Protein Heterodimerization Activity	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Response To Osmotic Stress Cell Cycle Arrest Cell Proliferation Negative Regulation Of Cell Proliferation Viral Process Protein Ubiquitination Cytosolic Calcium Ion Homeostasis Calcium Ion Transmembrane Transport Intrinsic Apoptotic Signaling Pathway	Osteoblast Differentiation Transcription From RNA Polymerase II Promoter Lymphocyte Differentiation Myeloid Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Maturation Definitive Hemopoiesis
Pathways		Signaling by ERBB2 Vif-mediated degradation of APOBEC3G Antigen processing: Ubiquitination & Proteasome degradation HIV Infection Host Interactions of HIV factors Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		33 interactors: ANAPC11 ARIH2 ASB11 CBFB CCNDBP1 COMMD1 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 DCUN1D3 DCUN1D4 DCUN1D5 GOLGA2 GPS1 NEDD8 PRKACA PTPN5 RBX1 RHOBTB1 RHOBTB2 RNF7 SMAD2 SMURF1 SOX30 TCEB1 TCEB2 TGFBR1 UBE2F VHL	9 interactors: CBFA2T2 CHGB COPRS CUL5 RAB2A RNF7 RUNX1 RUNX2 RUNX3
Entrez ID		8065	865
HPRD ID		03444	00418
Ensembl ID		ENSG00000166266	ENSG00000067955
Uniprot IDs		Q93034	Q13951
PDB IDs		3DPL 3DQV 4JGH	1CL3 1E50 1H9D
Enriched GO Terms of Interacting Partners?		Cullin Deneddylation Protein Deneddylation Cellular Protein Modification Process Protein Modification By Small Protein Removal Cellular Protein Metabolic Process Protein Neddylation Protein Modification By Small Protein Conjugation Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Protein Catabolic Process Cellular Response To Oxygen Levels Regulation Of Transcription From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Cellular Macromolecule Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter Proteolysis Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Binding Positive Regulation Of Cellular Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Cholesterol Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Response To Abiotic Stimulus Intracellular Signal Transduction Response To Hypoxia Activin Receptor Signaling Pathway Inactivation Of MAPK Activity Cellular Response To Growth Factor Stimulus Regulation Of Protein Binding Positive Regulation Of Cellular Biosynthetic Process Response To Growth Factor Positive Regulation Of Dense Core Granule Biogenesis Protein Polyubiquitination Positive Regulation Of Viral Transcription Peptidyl-threonine Phosphorylation Negative Regulation Of Cell Proliferation	Peripheral Nervous System Neuron Development Hair Follicle Morphogenesis Epidermis Morphogenesis Skin Morphogenesis Chondrocyte Differentiation Hair Follicle Development Hair Cycle Process Hair Cycle Peripheral Nervous System Development Skeletal System Development Positive Regulation Of Progesterone Secretion Regulation Of Cell Proliferation Regulation Of Progesterone Secretion Cell Maturation Regulation Of Hair Follicle Cell Proliferation Tissue Development Intrinsic Apoptotic Signaling Pathway Cartilage Development Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell Differentiation Transcription From RNA Polymerase II Promoter Skin Development Negative Regulation Of Granulocyte Differentiation Myeloid Progenitor Cell Differentiation Positive Regulation Of Granulocyte Differentiation Connective Tissue Development Epidermis Development Protein Neddylation Organ Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone H4-R3 Methylation Osteoblast Fate Commitment Regulation Of Female Gonad Development Regulation Of Cellular Process Epithelium Development Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Response To Redox State Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Hematopoietic Stem Cell Proliferation Apoptotic Signaling Pathway Regulation Of Odontogenesis Of Dentin-containing Tooth System Development Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Interferon-gamma Production Histone Arginine Methylation Regulation Of RNA Biosynthetic Process
Tagcloud ?		293te7 accumulated adenovirus cul2 cytoplasm deleted e1 e1b55k e3 e4orf6 efficiently export exported fastidiousness hadv heterotypic homotypic illustrate indispensable interacted interacts late ligase mre11 mrnas reason ubiquitin versa vice	abl alfa aml1 amplified apl bcr characterizing clonospecific cml confirmation debate eto igh immunoglobin inv issues leukaemia mow myh1 offers opportunity presently progress purposes quantitate rearrangements residual tcr truly
Tagcloud (Difference) ?		293te7 accumulated adenovirus cul2 cytoplasm deleted e1 e1b55k e3 e4orf6 efficiently export exported fastidiousness hadv heterotypic homotypic illustrate indispensable interacted interacts late ligase mre11 mrnas reason ubiquitin versa vice	abl alfa aml1 amplified apl bcr characterizing clonospecific cml confirmation debate eto igh immunoglobin inv issues leukaemia mow myh1 offers opportunity presently progress purposes quantitate rearrangements residual tcr truly
Tagcloud (Intersection) ?