UBE2F and UBA3

Number of citations of the paper that reports this interaction (PubMedID 19250909)
82

Data Source:
BioGRID (enzymatic study, enzymatic study, enzymatic study, pull down)

		UBE2F	UBA3
Description		ubiquitin conjugating enzyme E2 F (putative)	ubiquitin like modifier activating enzyme 3
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GO Annotations	Cellular Component	Nucleus Cytosol	Nucleus Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Transferase Activity NEDD8 Transferase Activity NEDD8 Conjugating Enzyme Activity NEDD8 Ligase Activity	Nucleotide Binding Protein Binding ATP Binding Ubiquitin-like Modifier Activating Enzyme Activity Ligase Activity NEDD8 Activating Enzyme Activity NEDD8 Transferase Activity Identical Protein Binding Protein Heterodimerization Activity
	Biological Process	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Innate Immune Response Protein Neddylation Defense Response To Virus	Mitotic Cell Cycle Proteolysis Endomitotic Cell Cycle Protein Modification Process Post-translational Protein Modification Protein Neddylation Regulation Of Cell Cycle
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Dectin-1 mediated noncanonical NF-kB signaling NIK-->noncanonical NF-kB signaling Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Lean body mass ( 28552196)	Meat-related diet ( 32066663)
Interacting Genes		13 interacting genes: CUL1 DCUN1D1 DCUN1D2 DCUN1D5 LCN2 NAE1 PAX6 RBX1 RC3H1 RNF34 RNF7 TRIM2 UBA3	16 interacting genes: CHD3 CPNE2 CUL5 DSCAM DUSP23 IMPA2 KDM1A NAE1 NEDD8 OGT RNF7 TRIM55 TRIM63 UBE2D2 UBE2F UBE2M
Entrez ID		140739	9039
HPRD ID		14812	04413
Ensembl ID		ENSG00000184182	ENSG00000144744
Uniprot IDs		Q969M7	F8W8D4 Q8TBC4
PDB IDs		2EDI 3FN1 4GBA	1R4M 1R4N 1TT5 1Y8X 1YOV 2LQ7 2NVU 3DBH 3DBL 3DBR 3FN1 3GZN 5JJM
Enriched GO Terms of Interacting Partners?		Protein Neddylation Protein Modification By Small Protein Conjugation Post-translational Protein Modification Cullin Family Protein Binding Protein Modification Process NEDD8 Transferase Activity Ubiquitin-like Protein Binding Positive Regulation Of Protein Neddylation Protein Polyubiquitination Protein Metabolic Process Regulation Of Protein Neddylation NEDD8 Activating Enzyme Activity Ubiquitin Protein Ligase Binding Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin Conjugating Enzyme Binding Positive Regulation Of Post-translational Protein Modification Macromolecule Metabolic Process Protein Ubiquitination NEDD8 Ligase Activity Ubiquitin Protein Ligase Activity Proteolysis Involved In Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-like Modifier Activating Enzyme Activity Regulation Of Post-translational Protein Modification Cullin-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex Macromolecule Catabolic Process Protein Catabolic Process Protein K48-linked Ubiquitination Ubiquitin Ligase Complex Positive Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Protein Modification Process Cytoplasm Cellular Response To Cytokine Stimulus Regulation Of Apoptotic Process Apoptotic Process Regulation Of Programmed Cell Death Programmed Cell Death Cell Death Cellular Response To Oxidative Stress Negative Regulation Of Signal Transduction By P53 Class Mediator Cellular Response To Stress Response To Cytokine Response To Peptide Cellular Response To Interleukin-1 Positive Regulation Of Hippocampal Neuron Apoptotic Process	Protein Neddylation Protein Modification By Small Protein Conjugation NEDD8 Transferase Activity Protein Modification Process Post-translational Protein Modification Regulation Of Cell Junction Assembly NEDD8 Conjugating Enzyme Activity Negative Regulation Of Focal Adhesion Disassembly NEDD8 Ligase Activity Protein Metabolic Process Regulation Of Postsynapse Assembly Protein Ubiquitination Regulation Of Synapse Assembly Erythropoietin-mediated Signaling Pathway Negative Regulation Of Growth Hormone Receptor Signaling Pathway Regulation Of Growth Hormone Receptor Signaling Pathway Reelin-mediated Signaling Pathway Epithelial To Mesenchymal Transition Ubiquitin-protein Transferase Activity Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cul5-RING Ubiquitin Ligase Complex Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein Polyubiquitination Layer Formation In Cerebral Cortex Mesenchymal Cell Differentiation Negative Regulation Of Focal Adhesion Assembly Regulation Of Synapse Organization Innate Immune Response Growth Hormone Receptor Signaling Pathway Ubiquitin Protein Ligase Activity Regulation Of Postsynapse Organization Proteolysis Involved In Protein Catabolic Process CGAS/STING Signaling Pathway Positive Regulation Of Focal Adhesion Assembly Nucleus Defense Response To Symbiont Proteolysis Transferase Activity Defense Response To Other Organism Negative Regulation Of Cell-matrix Adhesion Protein K11-linked Ubiquitination Regulation Of Cellular Component Organization Macromolecule Metabolic Process Regulation Of Neuron Migration Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Defense Response Regulation Of Glycolytic Process
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