UBE2F and RNF34

Number of citations of the paper that reports this interaction (PMID 19549727)
40

Data Source:
BioGRID (two hybrid)

		UBE2F	RNF34
Gene Name		ubiquitin-conjugating enzyme E2F (putative)	ring finger protein 34, E3 ubiquitin protein ligase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleus Cytoplasm Cytosol Plasma Membrane Endomembrane System Nuclear Speck
	Molecular Function	Protein Binding ATP Binding Ligase Activity NEDD8 Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity	P53 Binding Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity Phosphatidylinositol Phosphate Binding
	Biological Process	Protein Ubiquitination Protein Neddylation	Protein Ubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Cold Protein K48-linked Ubiquitination Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Oxygen Metabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: CUL1 CUL5 DCUN1D1 DCUN1D2 NAE1 NEDD8 RNF34 RNF7 UBA3	9 interactors: APP APPBP2 DNAJA3 NOD1 PHF7 TRIM23 UBE2D2 UBE2F UBE2H
Entrez ID		140739	80196
HPRD ID		14812	10509
Ensembl ID		ENSG00000184182	ENSG00000170633
Uniprot IDs		C9J212 H9KVB9 Q969M7	Q969K3
PDB IDs		2EDI 3FN1 4GBA
Enriched GO Terms of Interacting Partners?		Protein Neddylation Protein Modification By Small Protein Conjugation Apoptotic Process Cellular Protein Modification Process Programmed Cell Death Cell Death Death Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Intrinsic Apoptotic Signaling Pathway Protein Catabolic Process Cellular Protein Metabolic Process Proteolysis Mitotic Cell Cycle Cellular Macromolecule Catabolic Process Regulation Of Cell Cycle Apoptotic Signaling Pathway Protein Metabolic Process Negative Regulation Of Cell Cycle Cell Cycle Regulation Of Oxygen Metabolic Process Endomitotic Cell Cycle Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis Cell Cycle Arrest Mitotic Cell Cycle Process G1/S Transition Of Mitotic Cell Cycle Cellular Response To Cold Mitotic DNA Replication Checkpoint Catabolic Process Signal Transduction Negative Regulation Of Execution Phase Of Apoptosis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Signaling Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Communication DNA Replication Checkpoint Cell Cycle Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Response To Redox State Cellular Response To Stimulus Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Execution Phase Of Apoptosis	Positive Regulation Of Peptidase Activity Protein Modification By Small Protein Conjugation Regulation Of Innate Immune Response Protein K48-linked Ubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Innate Immune Response Positive Regulation Of Proteolysis Neuromuscular Junction Development TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Endopeptidase Activity Protein Metabolic Process Regulation Of Peptidase Activity Toll-like Receptor 4 Signaling Pathway Interleukin-8 Biosynthetic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Immune Response Zymogen Activation Defense Response Toll-like Receptor Signaling Pathway Synaptic Growth At Neuromuscular Junction Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Ubiquitination Positive Regulation Of Cysteine-type Endopeptidase Activity Cellular Protein Metabolic Process Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Endopeptidase Activity Innate Immune Response-activating Signal Transduction Positive Regulation Of Catalytic Activity Collateral Sprouting In Absence Of Injury Activation Of Innate Immune Response Regulation Of Proteolysis Interleukin-8 Production Protein Polyubiquitination Synapse Organization Regulation Of Protein Kinase Activity Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of Innate Immune Response Cellular Protein Modification Process Regulation Of Kinase Activity Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Axon Choice Point Recognition Activation-induced Cell Death Of T Cells
Tagcloud ?			aims blotting candidate confirm diaminopimelic downregulated e3 glutamyl glutathione gst hybrid immunoprecipitation interfering ip kappa ligase meso nod1 nucleotide oligomerization partner promoted pull regulator regulatory transfection transferase ubiquitination yeast
Tagcloud (Difference) ?			aims blotting candidate confirm diaminopimelic downregulated e3 glutamyl glutathione gst hybrid immunoprecipitation interfering ip kappa ligase meso nod1 nucleotide oligomerization partner promoted pull regulator regulatory transfection transferase ubiquitination yeast
Tagcloud (Intersection) ?