UBE2F and RNF7

Number of citations of the paper that reports this interaction (PMID 19250909)
47

Data Source:
BioGRID (pull down, x-ray crystallography)

		UBE2F	RNF7
Gene Name		ubiquitin-conjugating enzyme E2F (putative)	ring finger protein 7
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cul5-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding ATP Binding Ligase Activity NEDD8 Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity	Copper Ion Binding Protein Binding Zinc Ion Binding NEDD8 Transferase Activity Cullin Family Protein Binding
	Biological Process	Protein Ubiquitination Protein Neddylation	Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Protein Ubiquitination Negative Regulation Of Apoptotic Process Protein Neddylation Response To Redox State
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			Hepatitis C induced liver fibrosis ( 22841784)
Protein-Protein Interactions		9 interactors: CUL1 CUL5 DCUN1D1 DCUN1D2 NAE1 NEDD8 RNF34 RNF7 UBA3	34 interactors: ASB2 CASP7 CBFB CDC34 CHFR CSNK2A1 CSNK2B CUL1 CUL2 CUL3 CUL4A CUL4B CUL5 CYCS GEM GLMN IKBKG ITM2C MKRN3 MNAT1 NEDD4 NEDD4L NFKBIA PLA2G15 TCEB1 TCEB2 TRIM46 TRIM8 UBE2D1 UBE2D2 UBE2D4 UBE2F UBE2M UBE2Q1
Entrez ID		140739	9616
HPRD ID		14812	04840
Ensembl ID		ENSG00000184182
Uniprot IDs		C9J212 H9KVB9 Q969M7	Q9UBF6
PDB IDs		2EDI 3FN1 4GBA	2ECL
Enriched GO Terms of Interacting Partners?		Protein Neddylation Protein Modification By Small Protein Conjugation Apoptotic Process Cellular Protein Modification Process Programmed Cell Death Cell Death Death Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Intrinsic Apoptotic Signaling Pathway Protein Catabolic Process Cellular Protein Metabolic Process Proteolysis Mitotic Cell Cycle Cellular Macromolecule Catabolic Process Regulation Of Cell Cycle Apoptotic Signaling Pathway Protein Metabolic Process Negative Regulation Of Cell Cycle Cell Cycle Regulation Of Oxygen Metabolic Process Endomitotic Cell Cycle Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis Cell Cycle Arrest Mitotic Cell Cycle Process G1/S Transition Of Mitotic Cell Cycle Cellular Response To Cold Mitotic DNA Replication Checkpoint Catabolic Process Signal Transduction Negative Regulation Of Execution Phase Of Apoptosis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Signaling Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Communication DNA Replication Checkpoint Cell Cycle Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Response To Redox State Cellular Response To Stimulus Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Execution Phase Of Apoptosis	Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Protein Modification Process Protein Polyubiquitination Cellular Protein Metabolic Process Protein Metabolic Process Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Viral Process Regulation Of DNA-templated Transcription In Response To Stress Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Proteolysis Mitotic Cell Cycle Process G1/S Transition Of Mitotic Cell Cycle Protein K48-linked Ubiquitination Protein Monoubiquitination Positive Regulation Of Protein Metabolic Process Intrinsic Apoptotic Signaling Pathway Cell Cycle Positive Regulation Of Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle Process Negative Regulation Of Cell Cycle Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Cell Cycle Apoptotic Signaling Pathway Apoptotic Process Cellular Response To Oxygen Levels Positive Regulation Of Metabolic Process Cellular Response To Stimulus Programmed Cell Death Cellular Metabolic Process Cell Death Death Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Abiotic Stimulus Proteasomal Protein Catabolic Process Cell Cycle Arrest TRIF-dependent Toll-like Receptor Signaling Pathway
Tagcloud ?			biologically bridges consistently cul degraded e3 etoposide hect ligase ligases list nedd4 proteasome rbx2 redox ring roc2 sag scf sensitizes shortened substrates terminus transcriptionally tri ubiquitin ubiquitylated ubiquitylates ubiquitylation
Tagcloud (Difference) ?			biologically bridges consistently cul degraded e3 etoposide hect ligase ligases list nedd4 proteasome rbx2 redox ring roc2 sag scf sensitizes shortened substrates terminus transcriptionally tri ubiquitin ubiquitylated ubiquitylates ubiquitylation
Tagcloud (Intersection) ?