UBE2F and NAE1

Number of citations of the paper that reports this interaction (PMID 19250909)
47

Data Source:
BioGRID (enzymatic study)

		UBE2F	NAE1
Gene Name		ubiquitin-conjugating enzyme E2F (putative)	NEDD8 activating enzyme E1 subunit 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleus Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Protein Binding ATP Binding Ligase Activity NEDD8 Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity	Protein Binding NEDD8 Activating Enzyme Activity Ubiquitin Protein Ligase Binding Protein Heterodimerization Activity
	Biological Process	Protein Ubiquitination Protein Neddylation	Signal Transduction Mitotic DNA Replication Checkpoint Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Protein Neddylation Neuron Apoptotic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs			Adenosine triphosphate
Diseases
GWAS
Protein-Protein Interactions		9 interactors: CUL1 CUL5 DCUN1D1 DCUN1D2 NAE1 NEDD8 RNF34 RNF7 UBA3	11 interactors: ALG8 APP NEDD8 SREBF2 TP53BP2 TRIP12 UBA3 UBC UBE2F UBE2M UBQLN4
Entrez ID		140739	8883
HPRD ID		14812	04545
Ensembl ID		ENSG00000184182	ENSG00000159593
Uniprot IDs		C9J212 H9KVB9 Q969M7	A6NCK0 A8MU28 Q13564
PDB IDs		2EDI 3FN1 4GBA	1R4M 1R4N 1TT5 1YOV 2NVU 3DBH 3DBL 3DBR 3GZN
Enriched GO Terms of Interacting Partners?		Protein Neddylation Protein Modification By Small Protein Conjugation Apoptotic Process Cellular Protein Modification Process Programmed Cell Death Cell Death Death Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Intrinsic Apoptotic Signaling Pathway Protein Catabolic Process Cellular Protein Metabolic Process Proteolysis Mitotic Cell Cycle Cellular Macromolecule Catabolic Process Regulation Of Cell Cycle Apoptotic Signaling Pathway Protein Metabolic Process Negative Regulation Of Cell Cycle Cell Cycle Regulation Of Oxygen Metabolic Process Endomitotic Cell Cycle Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis Cell Cycle Arrest Mitotic Cell Cycle Process G1/S Transition Of Mitotic Cell Cycle Cellular Response To Cold Mitotic DNA Replication Checkpoint Catabolic Process Signal Transduction Negative Regulation Of Execution Phase Of Apoptosis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Signaling Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Communication DNA Replication Checkpoint Cell Cycle Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Response To Redox State Cellular Response To Stimulus Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Execution Phase Of Apoptosis	Protein Neddylation Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Cellular Protein Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Cycle Regulation Of ERBB Signaling Pathway Protein Metabolic Process Oligosaccharide-lipid Intermediate Biosynthetic Process Regulation Of Lipid Transport By Negative Regulation Of Transcription From RNA Polymerase II Promoter Synaptic Growth At Neuromuscular Junction Negative Regulation Of Protein Ubiquitination Signal Transduction By P53 Class Mediator Cholesterol Metabolic Process Ubiquitin-dependent Protein Catabolic Process Collateral Sprouting In Absence Of Injury Negative Regulation Of Histone H2A K63-linked Ubiquitination Endomitotic Cell Cycle Modification-dependent Protein Catabolic Process Sterol Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Histone Ubiquitination Negative Regulation Of Protein K63-linked Ubiquitination Notch Signaling Pathway Cellular Protein Catabolic Process Protein Ubiquitination Cellular Response To Growth Factor Stimulus Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Cholesterol Efflux Response To Growth Factor Protein Catabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Protein K63-linked Ubiquitination Regulation Of Proteolysis Axon Choice Point Recognition Negative Regulation Of Double-strand Break Repair Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of DNA Repair Intracellular Receptor Signaling Pathway Proteolysis Regulation Of Protein Ubiquitination Neuron Remodeling Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process
Tagcloud ?			addressed app bp1 bring clonogenic constructs conversely elusive emerged hnscc hnsccs hpv16 invovled ionizing modality naturally nedd8 neddylation oropharyngeal radioresistant radiosensitive radiosensitivity radiotherapy rays scc90 sirnas sq20b subpopulation upci
Tagcloud (Difference) ?			addressed app bp1 bring clonogenic constructs conversely elusive emerged hnscc hnsccs hpv16 invovled ionizing modality naturally nedd8 neddylation oropharyngeal radioresistant radiosensitive radiosensitivity radiotherapy rays scc90 sirnas sq20b subpopulation upci
Tagcloud (Intersection) ?