ZSCAN16 and AP1M1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		ZSCAN16	AP1M1
Name		zinc finger and SCAN domain containing 16	adaptor related protein complex 1 subunit mu 1
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus	Golgi Membrane Lysosomal Membrane Early Endosome Golgi Apparatus Cytosol Plasma Membrane Membrane AP-1 Adaptor Complex Clathrin Adaptor Complex Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Specific Granule Membrane Synapse Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Clathrin Adaptor Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Intracellular Protein Transport Protein Transport Vesicle-mediated Transport Melanosome Organization Endosome To Melanosome Transport Platelet Dense Granule Organization Melanosome Assembly
Pathways		None	Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Neutrophil degranulation
GWAS		Asthma and major depressive disorder ( 31619474 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Brain morphology (MOSTest) ( 32665545 ) Fish- and plant-related diet ( 32066663 ) Refractive error ( 32231278 ) Subcortical volume (MOSTest) ( 32665545 )	Coronary artery disease ( 33020668 )
Novel Interactors		None recorded	2 novel interactors: AKAP8L CD28
Interacting Genes		13 interacting genes: AP1M1 APP NTAQ1 PPL SCAND1 SLC25A38 TRIM41 TRIM55 TRIM63 ZNF24 ZNF446 ZSCAN22 ZSCAN32	103 interacting genes: AMOT AP1M2 AP2B1 ARFRP1 ARL6IP4 ARNT2 ATF4 AXIN2 BACH2 BCAR3 BRCA1 C7orf57 CASP8 CCDC33 CEP57L1 CORO7 CTLA4 DCX DISC1 DVL2 DZIP3 EFEMP2 EHD2 ENTR1 ETV6 EVI5L FAM219B FAM9B FKBP7 FXR1 FXR2 GAK GCSAM GRIN2A GRIN2B HNRNPC HOOK1 HOOK2 IKZF1 KIF13A KIF24 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 LAMP1 LDOC1 LNX1 LRATD2 LRMDA LZTS1 LZTS2 MDK MEA1 MID2 MTF1 MYOD1 NECAB1 NKAP NKAPD1 OLIG3 PAX6 PHC2 PICK1 PIGR PNMA5 PURB RAPGEF3 ROPN1 RP9 RSPH14 RUNDC3A SDCBP2 SELP SLC2A4 SP4 SPATA6 SRPK2 SSX2IP TEPSIN TFIP11 TGOLN2 THAP6 TIFA TNIP1 TRIM27 TRIM41 UBC VAMP4 VANGL2 ZBTB14 ZBTB3 ZBTB43 ZBTB44 ZBTB8A ZCCHC17 ZNF19 ZNF219 ZNF276 ZNF552 ZNF655 ZNF8 ZSCAN16
Entrez ID		80345	8907
HPRD ID		15792	04639
Ensembl ID		ENSG00000196812	ENSG00000072958
Uniprot IDs		B4DFB7 Q9H4T2	B3KNH5 Q59EK3 Q9BXS5
PDB IDs		2COT	Not available
GO Terms Enriched among Interactors		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Response To Interleukin-1 Innate Immune Response Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Defense Response To Symbiont Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Defense Response To Other Organism Amylin Binding Metal Ion Binding Regulation Of Purine Nucleotide Metabolic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Identical Protein Binding Zinc Ion Binding Glycine Import Into Mitochondrion Protein-N-terminal Asparagine Amidohydrolase Activity Protein-N-terminal Glutamine Amidohydrolase Activity Ubiquitin Protein Ligase Activity Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation	Identical Protein Binding Protein Binding Zinc Ion Binding Regulation Of RNA Metabolic Process DNA Binding Post-Golgi Vesicle-mediated Transport Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Domain Specific Binding Convergent Extension Involved In Neural Plate Elongation Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Trans-Golgi Network Membrane Regulation Of Transcription By RNA Polymerase II Clathrin-coated Endocytic Vesicle Cellular Localization Intracellular Transport Developmental Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Synaptic Plasticity Negative Regulation Of RNA Metabolic Process Sequence-specific Double-stranded DNA Binding Protein Complex Involved In Cell Adhesion Microtubule Convergent Extension Involved In Organogenesis Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion FHF Complex Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of Regulatory T Cell Differentiation Convergent Extension Involved In Gastrulation Dentate Gyrus Development Protein Localization To Membrane Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity NMDA Glutamate Receptor Activity Regulation Of RNA Biosynthetic Process