ZSCAN16 and PPL

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZSCAN16	PPL
Description		zinc finger and SCAN domain containing 16	periplakin
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GO Annotations	Cellular Component	Nucleus	Cornified Envelope Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Membrane Desmosome Extracellular Exosome Anchoring Junction
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cadherin Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Response To Mechanical Stimulus Keratinization Wound Healing Intermediate Filament Cytoskeleton Organization
Pathways			Formation of the cornified envelope Butyrophilin (BTN) family interactions
Drugs
Diseases
GWAS		Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)	Adult body size ( 32376654) Appendicular lean mass ( 33097823) Cancer ( 29299148) Diastolic blood pressure ( 27841878 28135244) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 28552196) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung cancer (asbestos exposure interaction) ( 22637743) Metabolite levels (HVA/MHPG ratio) ( 23319000) Mitochondrial DNA copy number (white blood cells) ( 30704525) Systolic blood pressure ( 27841878) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		13 interacting genes: AP1M1 APP NTAQ1 PPL SCAND1 SLC25A38 TRIM41 TRIM55 TRIM63 ZNF24 ZNF446 ZSCAN22 ZSCAN32	44 interacting genes: ACTR5 AHCYL1 AKT1 ALAS1 C6orf141 CASP6 CEP57L1 COL17A1 DES EVPL HECTD3 IKZF1 ITSN1 KAZN KCTD21 KNSTRN KRT25 KRT39 KRT8 MRPL28 OPRM1 PBX4 PICK1 PLEKHA7 POF1B PPHLN1 PTEN RAB3IP SKIL TRAF2 TRIM27 TSC22D4 UBC UPRT USP7 VIM WEE2-AS1 ZBTB26 ZNF165 ZNF213 ZNF263 ZNF474 ZSCAN1 ZSCAN16
Entrez ID		80345	5493
HPRD ID		15792	04187
Ensembl ID		ENSG00000196812	ENSG00000118898
Uniprot IDs		B4DFB7 Q9H4T2	O60437
PDB IDs		2COT	4Q28
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Response To Interleukin-1 Innate Immune Response Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Defense Response To Symbiont Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Defense Response To Other Organism Amylin Binding Metal Ion Binding Regulation Of Purine Nucleotide Metabolic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Identical Protein Binding Zinc Ion Binding Glycine Import Into Mitochondrion Protein-N-terminal Asparagine Amidohydrolase Activity Protein-N-terminal Glutamine Amidohydrolase Activity Ubiquitin Protein Ligase Activity Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation	Intermediate Filament Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Identical Protein Binding Intermediate Filament Cytoskeleton Cellular Response To Rapamycin TORC1 Signaling Intermediate Filament Organization Regulation Of RNA Metabolic Process TOR Signaling Desmosome Response To Rapamycin Cell-cell Junction PML Body Regulation Of Nucleobase-containing Compound Metabolic Process Protein Domain Specific Binding Cellular Response To Ether
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