BICC1 and GABARAPL1

Number of citations of the paper that reports this interaction (PubMedID 37219487)
66

Data Source:
BioGRID (unspecified method)

		BICC1	GABARAPL1
Description		BicC family RNA binding protein 1	GABA type A receptor associated protein like 1
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GO Annotations	Cellular Component	Cytoplasm	Autophagosome Membrane Cytoplasm Mitochondrion Autophagosome Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Microtubule Plasma Membrane Cilium Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Ciliary Basal Body
	Molecular Function	Nucleic Acid Binding RNA Binding	Protein Binding Phospholipid Binding Phosphatidylethanolamine Binding Tat Protein Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding
	Biological Process	Kidney Development Determination Of Left/right Symmetry Heart Development Negative Regulation Of Canonical Wnt Signaling Pathway	Autophagosome Assembly Mitophagy Autophagy Cellular Response To Nitrogen Starvation Glycophagy Autophagosome Maturation
Pathways			Macroautophagy
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 31152163 29403010) Chronotype ( 30696823) Glaucoma ( 31959993 30054594) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 29891935 33627673) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hemoglobin ( 29403010 32888494) Hemoglobin levels ( 32327693) Intraocular pressure ( 31959993) LDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Manganese levels ( 26025379) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Midgestational circulating levels of PCBs ( 28235828) Morning person ( 30696823) Myopia ( 27182965) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Pulse pressure ( 27841878) Pursuit maintenance gain ( 29064472) Refractive error ( 32231278 23396134) Serum uric acid levels ( 30993211 29403010) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Urate levels ( 31985003 31578528) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		4 interacting genes: GABARAP GABARAPL1 GABARAPL2 MAP1LC3C	87 interacting genes: AHNAK2 AMBRA1 ANK2 APPL1 ARFGAP1 ATG13 ATG4A ATG4B ATG4D AZI2 BICC1 BNIP3L BRD9 BSCL2 BSDC1 CALCOCO1 CALCOCO2 CARS2 CCT2 CDC37 CREB3L2 CUL3 DISC1 DVL2 DYNLL1 ERBB2 ERBB3 FUNDC1 G3BP1 KBTBD7 KRTAP10-3 KRTAP10-7 KRTAP10-9 KXD1 MAP4K2 MAPK15 MEFV MLX MYBPC1 NCOR1 NEDD4 NFIA NUFIP2 OPRK1 OPTN OSBPL3 PBXIP1 PSMB4 PTPRR RABGAP1 RABGAP1L RB1CC1 RCN2 RESF1 RETREG3 SCYL3 SEC62 SNCA SQSTM1 SRPK1 SRPK2 STK3 STRN3 TAX1BP1 TBC1D1 TBC1D10A TBC1D10B TBC1D16 TBC1D17 TBC1D2 TBC1D25 TBC1D2B TBC1D5 TBC1D7 TBC1D9 TBC1D9B THAP7 TMEM131 TNIP1 TP53INP1 TRIM21 TRIM25 TRIM32 UMAD1 VDR WDFY3 ZBTB22
Entrez ID		80114	23710
HPRD ID		18993	07601
Ensembl ID		ENSG00000122870	ENSG00000139112
Uniprot IDs		Q9H694	Q9H0R8
PDB IDs		4RQM 4RQN 6GY4	2L8J 2R2Q 5DPT 5LXH 5LXI 6HOI 6HOL 6YOO 7AA7 7AA9 7JHX 8X8A
Enriched GO Terms of Interacting Partners?		Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Autophagosome Maturation Autophagosome Membrane Mitophagy Autophagy Of Mitochondrion Autophagosome Autophagosome Assembly GABA Receptor Binding Autophagosome Organization Phospholipid Binding Protein-containing Complex Disassembly Macroautophagy Vacuole Organization Cellular Response To Starvation Beta-tubulin Binding Response To Starvation Cellular Response To Nutrient Levels Autophagy Ubiquitin Protein Ligase Binding Response To Nutrient Levels Organelle Assembly Cytoplasmic Vesicle Microtubule Protein-containing Complex Organization L-cysteine Transaminase Activity Cellular Response To Stress Positive Regulation Of Protein K48-linked Ubiquitination Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein K48-linked Ubiquitination Microtubule Binding Endomembrane System Tat Protein Binding Protein Transport Glycophagy Cellular Component Assembly Aggrephagy Organelle Organization Protein Localization To Endoplasmic Reticulum Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Protein Polyubiquitination Establishment Of Protein Localization Regulation Of Protein Catabolic Process Smooth Endoplasmic Reticulum Regulation Of Proteolysis Positive Regulation Of ATP-dependent Activity Glycogen Catabolic Process Golgi Apparatus Polysaccharide Catabolic Process	Autophagosome Regulation Of Cilium Assembly Autophagy Macroautophagy GTPase Activator Activity Regulation Of Organelle Assembly Cytosol Regulation Of Autophagy Positive Regulation Of Autophagy Autophagy Of Mitochondrion Regulation Of Cell Projection Assembly Mitophagy Autophagosome Assembly Autophagosome Organization Aggrephagy Cytoplasmic Vesicle Piecemeal Microautophagy Of The Nucleus Cytoplasm Regulation Of Cell Projection Organization Microautophagy Nucleophagy Positive Regulation Of Catabolic Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Vacuole Organization Regulation Of Organelle Organization Positive Regulation Of Metabolic Process Protein-phosphatidylethanolamide Deconjugating Activity Catabolic Process Protein Delipidation Response To Mitochondrial Depolarisation Organelle Assembly Regulation Of Macroautophagy Atg1/ULK1 Kinase Complex Regulation Of Cellular Component Organization Positive Regulation Of Macroautophagy Regulation Of Intracellular Signal Transduction Protein Polyubiquitination Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Phagophore Assembly Site Negative Regulation Of Signal Transduction ERBB3:ERBB2 Complex Protein Localization To Phagocytic Vesicle Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Metabolic Process Response To Stress Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of Viral Process
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