ZNF212 and NFKBIA

Number of citations of the paper that reports this interaction (PMID 18255255)
1

Data Source:
BioGRID (two hybrid)

		ZNF212	NFKBIA
Gene Name		zinc finger protein 212	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Cytoplasm Cytosol Plasma Membrane I-kappaB/NF-kappaB Complex
	Molecular Function	DNA Binding Transcription Cofactor Activity Protein Binding Zinc Ion Binding Identical Protein Binding	Protein Binding Transcription Factor Binding Nuclear Localization Sequence Binding Enzyme Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Protein Complex Binding Identical Protein Binding NF-kappaB Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter	Protein Import Into Nucleus, Translocation Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Apoptotic Process Cytoplasmic Sequestering Of NF-kappaB Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Lipid Storage Viral Process Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Type I Interferon Production Response To Muramyl Dipeptide Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Regulation Of Cell Proliferation Regulation Of NF-kappaB Import Into Nucleus Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of Apoptotic Process Response To Exogenous DsRNA Negative Regulation Of DNA Binding Innate Immune Response Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Cold Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Pathways		Generic Transcription Pathway	Signaling by the B Cell Receptor (BCR) NF-kB is activated and signals survival Downstream TCR signaling Toll Like Receptor 7/8 (TLR7/8) Cascade RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling FCERI mediated NF-kB activation MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs p75NTR signals via NF-kB MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Innate Immune System Signalling by NGF TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA p75 NTR receptor-mediated signalling MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways TCR signaling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Activation of NF-kappaB in B cells Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Fc epsilon receptor (FCERI) signaling TRAF6 mediated NF-kB activation Adaptive Immune System TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS			Psoriasis ( 20953189 20953190)
Protein-Protein Interactions		23 interactors: ATF3 ATF4 CREB3L2 CSK DPF2 DUSP6 FAM90A1 FHL2 GNL1 HBP1 LOC155060 NFKBIA NKX2-3 PPARGC1B PTP4A1 RND1 SAP30BP SF3A3 SUV39H2 ZNF3 ZNF331 ZNF408 ZZZ3	87 interactors: ABL1 ARRB1 ARRB2 ATF4 AURKA BARD1 BTRC CAPN1 CAPN2 CD7 CDC34 CHUK COMMD1 COPS8 CSNK2A1 CUL1 DNAJA3 DYNLL1 EIF2AK2 FBXW11 G3BP2 HDAC1 HDAC3 HNRNPA1 HOXA9 HOXB7 HSPB1 IKBKAP IKBKB IKBKE IKBKG IKZF4 ITPK1 JAK2 LCK LYL1 MAP3K1 MAP3K14 MAP3K2 MAP3K3 MCM5 MCM7 MED19 NCOR2 NEDD9 NFKB1 NFKB2 NFKBIB NKIRAS1 NKIRAS2 PIK3R1 PIR POLR2C POM121 PRKCA PRKCI PSMA2 PTPN1 PTPN13 RBX1 REL RELA RNF7 RPS6KA1 RPS6KA3 RWDD3 SKP1 SLC25A4 SLC25A5 SRC ST7 SUMO1 SUMO2 SUMO3 SUMO4 TBK1 TNF TNFSF11 TP53 TUBA1B UBE2D1 UBE2D2 UBE2D3 UBE2E3 UBE2L3 VCP ZNF212
Entrez ID		7988	4792
HPRD ID		03859	01235
Ensembl ID		ENSG00000170260	ENSG00000100906
Uniprot IDs		B3KQE6 Q9UDV6	P25963
PDB IDs			1IKN 1NFI
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Biosynthetic Process Regulation Of Cellular Process Cellular Response To Stress Cellular Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein Positive Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Response To Organic Substance Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Response To Unfolded Protein Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Response To Endoplasmic Reticulum Stress Regulation Of Bone Resorption Signal Transduction Regulation Of Bone Remodeling Intracellular Receptor Signaling Pathway Trabecula Morphogenesis Signaling Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Chylomicron Remnant Clearance Post-embryonic Digestive Tract Morphogenesis Cellular Response To Stimulus Negative Regulation Of ERK1 And ERK2 Cascade Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway	Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Signal Transduction Cellular Response To Stimulus Negative Regulation Of Cell Death Cellular Metabolic Process Toll-like Receptor Signaling Pathway Cellular Protein Modification Process Regulation Of Cellular Process Signaling Intracellular Signal Transduction Immune Response Negative Regulation Of Programmed Cell Death Cell Communication Regulation Of Cell Death Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Signal Transduction Activation Of Innate Immune Response Innate Immune Response Negative Regulation Of Apoptotic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Organic Substance Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune System Process Regulation Of Metabolic Process Regulation Of Apoptotic Process Regulation Of Signaling Positive Regulation Of Signal Transduction Cellular Protein Metabolic Process Response To Organic Substance Regulation Of Immune System Process I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Regulation Of Gene Expression Response To Growth Factor Regulation Of Cytokine Production Response To Stress Regulation Of Nitrogen Compound Metabolic Process Regulation Of Immune Response
Tagcloud ?		adenocarcinomas assisted ba barrett bas biologically consistently desorption dr5 electrophoresis erbb3 esophageal examples finger flight ihc interesting ionization klf6 lgi1 maldi mucosae spots tandem tof validated validation znf146 znf363	1alpha advance aggressiveness biopsies cd31 collectively december dehydrogenase demands deregulated diffuse doi enhancing enzymes gapdh glyceraldehyde glycolytic hif hodgkin inactive leu lymphoma lymphomagenesis online promote publication traf2 transformed vascularization
Tagcloud (Difference) ?		adenocarcinomas assisted ba barrett bas biologically consistently desorption dr5 electrophoresis erbb3 esophageal examples finger flight ihc interesting ionization klf6 lgi1 maldi mucosae spots tandem tof validated validation znf146 znf363	1alpha advance aggressiveness biopsies cd31 collectively december dehydrogenase demands deregulated diffuse doi enhancing enzymes gapdh glyceraldehyde glycolytic hif hodgkin inactive leu lymphoma lymphomagenesis online promote publication traf2 transformed vascularization
Tagcloud (Intersection) ?