ZNF212 and DUSP6

Number of citations of the paper that reports this interaction (PMID 18255255)
1

Data Source:
BioGRID (two hybrid)

		ZNF212	DUSP6
Gene Name		zinc finger protein 212	dual specificity phosphatase 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	DNA Binding Transcription Cofactor Activity Protein Binding Zinc Ion Binding Identical Protein Binding	Protein Tyrosine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter	Inactivation Of MAPK Activity Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Dorsal/ventral Pattern Formation Response To Organic Cyclic Compound Cell Differentiation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Peptidyl-tyrosine Dephosphorylation TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Response To Drug Regulation Of Endodermal Cell Fate Specification Positive Regulation Of Apoptotic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Stress-activated MAPK Cascade Response To Nitrosative Stress Regulation Of Heart Growth Negative Regulation Of ERK1 And ERK2 Cascade
Pathways		Generic Transcription Pathway	Toll Like Receptor 7/8 (TLR7/8) Cascade ERKs are inactivated Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade ERK/MAPK targets Innate Immune System ERKs are inactivated Signalling by NGF MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade ERK/MAPK targets MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS
Protein-Protein Interactions		23 interactors: ATF3 ATF4 CREB3L2 CSK DPF2 DUSP6 FAM90A1 FHL2 GNL1 HBP1 LOC155060 NFKBIA NKX2-3 PPARGC1B PTP4A1 RND1 SAP30BP SF3A3 SUV39H2 ZNF3 ZNF331 ZNF408 ZZZ3	6 interactors: MAPK1 MAPK3 MDFI SRPK1 TEX11 ZNF212
Entrez ID		7988	1848
HPRD ID		03859	04124
Ensembl ID		ENSG00000170260	ENSG00000139318
Uniprot IDs		B3KQE6 Q9UDV6	Q16828
PDB IDs			1HZM 1MKP
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Biosynthetic Process Regulation Of Cellular Process Cellular Response To Stress Cellular Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein Positive Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Response To Organic Substance Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Response To Unfolded Protein Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Response To Endoplasmic Reticulum Stress Regulation Of Bone Resorption Signal Transduction Regulation Of Bone Remodeling Intracellular Receptor Signaling Pathway Trabecula Morphogenesis Signaling Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Chylomicron Remnant Clearance Post-embryonic Digestive Tract Morphogenesis Cellular Response To Stimulus Negative Regulation Of ERK1 And ERK2 Cascade Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway	Regulation Of Golgi Inheritance Caveolin-mediated Endocytosis Regulation Of Golgi Organization Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of Early Endosome To Late Endosome Transport Activation Of MAPK Activity Regulation Of Stress-activated MAPK Cascade Developmental Process Involved In Reproduction JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of MAP Kinase Activity MAPK Cascade Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Response To Epidermal Growth Factor Regulation Of Cellular Response To Heat Activation Of Protein Kinase Activity Signal Transduction By Phosphorylation Positive Regulation Of Protein Serine/threonine Kinase Activity Lipopolysaccharide-mediated Signaling Pathway Regulation Of MAP Kinase Activity Response To Growth Hormone Response To Exogenous DsRNA Toll-like Receptor 5 Signaling Pathway JAK-STAT Cascade Toll-like Receptor 10 Signaling Pathway Single Organism Reproductive Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Response To Heat Activation Of MAPKK Activity MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Intracellular Transport Toll-like Receptor 3 Signaling Pathway Positive Regulation Of MAPK Cascade Response To DsRNA Reproductive Process MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Toll-like Receptor 4 Signaling Pathway Reproductive Structure Development Reproductive System Development Sensory Perception Of Pain Negative Regulation Of Binding Viral Process Positive Regulation Of Transferase Activity
Tagcloud ?		adenocarcinomas assisted ba barrett bas biologically consistently desorption dr5 electrophoresis erbb3 esophageal examples finger flight ihc interesting ionization klf6 lgi1 maldi mucosae spots tandem tof validated validation znf146 znf363	adenocarcinoma agar assays downregulated du145 dual experiments interleukin invasion knockdown lncap matrix mediator metallopeptidase metastasis numerous overexpression phosphatase pivotal plays proliferation promoted prostate remains soft specificity suppressed taken unclear
Tagcloud (Difference) ?		adenocarcinomas assisted ba barrett bas biologically consistently desorption dr5 electrophoresis erbb3 esophageal examples finger flight ihc interesting ionization klf6 lgi1 maldi mucosae spots tandem tof validated validation znf146 znf363	adenocarcinoma agar assays downregulated du145 dual experiments interleukin invasion knockdown lncap matrix mediator metallopeptidase metastasis numerous overexpression phosphatase pivotal plays proliferation promoted prostate remains soft specificity suppressed taken unclear
Tagcloud (Intersection) ?