HPS6 and MARK4

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		HPS6	MARK4
Gene Name		Hermansky-Pudlak syndrome 6	MAP/microtubule affinity-regulating kinase 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane BLOC-2 Complex Early Endosome Membrane	Centrosome Microtubule Organizing Center Cytosol Microtubule Cytoskeleton Neuron Projection
	Molecular Function	Rab GTPase Binding GTP-dependent Protein Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Gamma-tubulin Binding Ubiquitin Binding Tau-protein Kinase Activity
	Biological Process	Organelle Organization Blood Coagulation Melanocyte Differentiation Protein Localization To Membrane	Microtubule Cytoskeleton Organization Microtubule Bundle Formation Protein Phosphorylation Organelle Organization Nervous System Development Positive Regulation Of Programmed Cell Death
Pathways			Organelle biogenesis and maintenance Assembly of the primary cilium Anchoring of the basal body to the plasma membrane
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: CREB1 EP300 HPS5 KIAA0020 MARK4 MNAT1 OSGEP PIK3CB TTC19	28 interactors: CDC42 HGS HNRNPK HPS6 KHDRBS3 KRT31 KRT40 MAP2 MAP4 MAPT MTUS2 NEDD4 NOTCH2NL ODF2 PARD6A PNMA1 PRKCG PRKCI PRNP RPTOR STK11 TUBA4A TUBB TUBG1 UBC YWHAB YWHAH YWHAZ
Entrez ID		79803	57787
HPRD ID		08471	09402
Ensembl ID		ENSG00000166189	ENSG00000007047
Uniprot IDs		Q86YV9	Q96L34
PDB IDs
Enriched GO Terms of Interacting Partners?		G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Viral Transcription Regulation Of Viral Transcription Positive Regulation Of Viral Process Cell Cycle Process Histone H2B Acetylation Protein Stabilization Posttranscriptional Regulation Of Gene Expression Threonylcarbamoyladenosine Biosynthetic Process Viral Process Cell Cycle Regulation Of Body Fluid Levels Phosphatidylinositol-mediated Signaling N-terminal Peptidyl-lysine Acetylation Regulation Of Protein Stability Notch Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Regulation Of Viral Process G1/S Transition Of Mitotic Cell Cycle Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Mitotic Cell Cycle Process Circadian Rhythm Threonylcarbamoyladenosine Metabolic Process Regulation Of Tubulin Deacetylation Cellular Response To Fibroblast Growth Factor Stimulus Mitotic Cell Cycle Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Innate Immune Response Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Organelle Organization Phosphorylation Negative Regulation Of Transcription By Competitive Promoter Binding Lung Development Positive Regulation By Host Of Viral Transcription Embryonic Cleavage Mitochondrial Respiratory Chain Complex III Assembly Respiratory Tube Development Regulation Of Cellular Protein Metabolic Process Response To Hormone Fc Receptor Signaling Pathway N-terminal Protein Amino Acid Acetylation Response To Stress Regulation Of Clathrin-mediated Endocytosis Lung Saccule Development	Cellular Localization G2/M Transition Of Mitotic Cell Cycle Enzyme Linked Receptor Protein Signaling Pathway Establishment Of Localization In Cell Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Golgi Localization Regulation Of Cell Projection Organization Positive Regulation Of Transport Cell Cycle Cell Cycle Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Intracellular Transport Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Neuron Development Positive Regulation Of Intracellular Transport Regulation Of Intracellular Transport Microtubule Cytoskeleton Organization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cellular Localization Regulation Of Cell Morphogenesis Response To Stimulus Microtubule-based Process Regulation Of Apoptotic Process Cellular Response To Organic Substance Cellular Component Assembly Establishment Of Golgi Localization Neuron Differentiation Cytoskeleton Organization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Response To Stress Axonogenesis Regulation Of Cellular Component Organization Neuron Projection Development Negative Regulation Of ERBB Signaling Pathway Regulation Of Cell Death Generation Of Neurons Membrane Organization Axon Development Cell Morphogenesis Involved In Neuron Differentiation Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Glucocorticoid Receptor Signaling Pathway Neurogenesis
Tagcloud ?			acetate activator antimetastatic ap atra benzamido benzoic bis consequently cytotoxicity derivative includes interfering inverted l5 metalloproteinase mmp noncytotoxic partly plasminogen proteolytic question tac tetradecanoylphorbol tpa trimethylsilyl urokinase zymographic
Tagcloud (Difference) ?			acetate activator antimetastatic ap atra benzamido benzoic bis consequently cytotoxicity derivative includes interfering inverted l5 metalloproteinase mmp noncytotoxic partly plasminogen proteolytic question tac tetradecanoylphorbol tpa trimethylsilyl urokinase zymographic
Tagcloud (Intersection) ?