HPS6 and MARK4

Number of citations: 0 (PubMedID 16169070)
Data Source: HPRD (two hybrid)

		HPS6	MARK4
Name		HPS6 biogenesis of lysosomal organelles complex 2 subunit 3	microtubule affinity regulating kinase 4
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Endosome Early Endosome Endoplasmic Reticulum Cytosol Membrane BLOC-2 Complex Early Endosome Membrane	Gamma-tubulin Complex Cytoplasm Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Microtubule Cytoskeleton Dendrite Midbody Ciliary Basal Body Cell Projection Neuron Projection
	Molecular Function	Protein Binding GTP-dependent Protein Binding Small GTPase Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Cytoskeletal Anchor Activity Kinase Activity Transferase Activity Gamma-tubulin Binding Ubiquitin Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity
	Biological Process	Lipid Metabolic Process Blood Coagulation Protein Secretion Lysosome Localization Pigmentation Lipid Homeostasis Platelet Dense Granule Organization Protein Localization To Membrane Melanosome Assembly	Microtubule Cytoskeleton Organization Microtubule Bundle Formation Protein Phosphorylation Nervous System Development Cell Projection Organization Intracellular Signal Transduction Positive Regulation Of Programmed Cell Death Cilium Organization Positive Regulation Of Cilium Assembly Positive Regulation Of Cell Cycle Regulation Of Centrosome Cycle Microtubule Polymerization Cell Division Cilium Disassembly Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Protein Localization To Centrosome
Pathways		None	Anchoring of the basal body to the plasma membrane
Drugs		None	Fostamatinib
Diseases		Hermansky-Pudlak syndrome (HPS)	None
GWAS		Household income (MTAG) ( 31844048 ) Intelligence (MTAG) ( 29326435 )	Adult body size ( 32376654 ) Advanced age-related macular degeneration ( 26691988 ) Alzheimer's disease or family history of Alzheimer's disease ( 30617256 ) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717 ) Basophil count ( 32888494 ) Body mass index ( 26426971 ) Body mass index (age>50) ( 26426971 ) Body mass index x age interaction ( 26426971 ) Body mass index x sex x age interaction (4df test) ( 26426971 ) Eosinophil count ( 32888494 27863252 ) Eosinophil percentage of white cells ( 32888494 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Granulocyte count ( 27863252 ) Hematocrit ( 27863252 32888494 ) Hemoglobin ( 32888494 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Immature fraction of reticulocytes ( 32888494 ) L1-L4 bone mineral density x serum urate levels interaction ( 34046847 ) LDL cholesterol levels ( 32203549 ) Lymphocyte count ( 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Mean platelet volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Monocyte count ( 32888494 27863252 ) Monocyte percentage of white cells ( 27863252 32888494 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 27863252 ) Neutrophil percentage of white cells ( 32888494 ) Parental longevity (father's attained age) ( 29227965 ) Platelet count ( 27863252 32888494 ) Platelet distribution width ( 27863252 32888494 ) Plateletcrit ( 32888494 27863252 ) Red blood cell count ( 32888494 ) Red cell distribution width ( 32888494 ) Reticulocyte count ( 32888494 ) Sum basophil neutrophil counts ( 27863252 ) Sum eosinophil basophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) Triglyceride levels ( 32203549 ) White blood cell count ( 27863252 32888494 )
Interacting Genes		11 interacting genes: CREB1 EP300 HPS5 MARK4 MNAT1 OSGEP PIK3CB PUM3 SUMO2 TTC19 UBC	32 interacting genes: AKT1 APLNR CDC42 HGS HNRNPK HPS6 KHDRBS3 KRT31 KRT40 MAP2 MAP4 MAPT MED20 MTUS2 NEDD4 NLRP3 NOTCH2NLA ODF2 PARD6A PNMA1 PRKCG PRKCI PRNP PTBP1 RPTOR STK11 TUBA4A TUBB TUBG1 YWHAB YWHAH YWHAZ
Entrez ID		79803	57787
HPRD ID		08471	09402
Ensembl ID		ENSG00000166189	ENSG00000007047
Uniprot IDs		Q86YV9	Q96L34
PDB IDs		Not available	5ES1 8XFL
GO Terms Enriched among Interactors		Protein Tag Activity Nucleoplasm Chemotaxis To Arachidonate Transcription Coactivator Binding Tau Protein Binding Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Midbody Positive Regulation Of Cardiac Muscle Tissue Development Positive Regulation Of Transforming Growth Factor Beta3 Production Secretory Granule Organization Locomotion Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity BLOC-2 Complex TRNA N(6)-L-threonylcarbamoyladenine Synthase Activity	Microtubule Cytoskeleton Protein Domain Specific Binding Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Phosphoserine Residue Binding Microtubule Regulation Of Cellular Component Organization Cytosol Cytoskeleton Structural Molecule Activity Regulation Of Transport Golgi Localization Organelle Organization Cytoplasm Regulation Of Cellular Localization Tubulin Binding Regulation Of Cell Communication Regulation Of Signaling Cilium Intracellular Protein Localization GTP-dependent Protein Binding Cytoskeleton Organization Extracellular Exosome Regulation Of Neuron Projection Development Positive Regulation Of Transport Regulation Of Synapse Organization Negative Regulation Of Cell Projection Organization Positive Regulation Of Vesicle Transport Along Microtubule Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Supramolecular Fiber Organization Regulation Of Signal Transduction Regulation Of Protein Localization Regulation Of TORC1 Signaling Neuron Projection Main Axon Nuclear Receptor-mediated Corticosteroid Signaling Pathway Structural Constituent Of Cytoskeleton Protein Targeting PAR Polarity Complex Enzyme Binding Regulation Of Cell Growth Microtubule-based Process Establishment Of Golgi Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Microtubule Binding Regulation Of Cell Development Regulation Of Organelle Transport Along Microtubule Transmembrane Transporter Binding Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Nervous System Development