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HPS6 and PIK3CB
Number of citations of the paper that reports this interaction (PMID
21900206
)
27
Data Source:
BioGRID
(two hybrid)
HPS6
PIK3CB
Gene Name
Hermansky-Pudlak syndrome 6
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Endoplasmic Reticulum
Membrane
BLOC-2 Complex
Early Endosome Membrane
Nucleus
Cytosol
Plasma Membrane
Phosphatidylinositol 3-kinase Complex
Molecular Function
Rab GTPase Binding
GTP-dependent Protein Binding
Protein Binding
ATP Binding
1-phosphatidylinositol-3-kinase Activity
Phosphatidylinositol 3-kinase Activity
1-phosphatidylinositol-4-phosphate 3-kinase Activity
Insulin Receptor Substrate Binding
Phosphatidylinositol-4,5-bisphosphate 3-kinase Activity
Biological Process
Organelle Organization
Blood Coagulation
Melanocyte Differentiation
Protein Localization To Membrane
Activation Of MAPK Activity
Regulation Of Cell-matrix Adhesion
Phospholipid Metabolic Process
Phosphatidylinositol Biosynthetic Process
Cellular Calcium Ion Homeostasis
Autophagy
Chemotaxis
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
G-protein Coupled Receptor Signaling Pathway
Blood Coagulation
Insulin Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Autophagy
Phosphatidylinositol 3-kinase Signaling
Cell Migration
Platelet Activation
Phosphatidylinositol-3-phosphate Biosynthetic Process
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Embryonic Cleavage
Small Molecule Metabolic Process
Innate Immune Response
Phosphatidylinositol Phosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
T Cell Receptor Signaling Pathway
Leukocyte Migration
Platelet Aggregation
Regulation Of Clathrin-mediated Endocytosis
Pathways
Signaling by the B Cell Receptor (BCR)
Signaling by GPCR
Metabolism of lipids and lipoproteins
Signaling by FGFR in disease
Signaling by EGFRvIII in Cancer
Signaling by SCF-KIT
Downstream signaling events of B Cell Receptor (BCR)
DAP12 signaling
PI3K/AKT activation
Interleukin receptor SHC signaling
PI-3K cascade
Role of phospholipids in phagocytosis
Phospholipid metabolism
Fcgamma receptor (FCGR) dependent phagocytosis
PI3K Cascade
Signaling by PDGF
DAP12 interactions
GAB1 signalosome
G-protein beta:gamma signalling
Signaling by ERBB4
Constitutive PI3K/AKT Signaling in Cancer
Role of LAT2/NTAL/LAB on calcium mobilization
PI3K events in ERBB4 signaling
Signaling by ERBB2
Signaling by EGFR
GPCR downstream signaling
TCR signaling
Signaling by Interleukins
Signaling by VEGF
Downstream signal transduction
Fc epsilon receptor (FCERI) signaling
Signaling by EGFR in Cancer
Nephrin interactions
Interleukin-2 signaling
PI3K/AKT Signaling in Cancer
Platelet activation, signaling and aggregation
Interleukin-3, 5 and GM-CSF signaling
Adaptive Immune System
Downstream TCR signaling
IRS-mediated signalling
PIP3 activates AKT signaling
IGF1R signaling cascade
VEGFA-VEGFR2 Pathway
Synthesis of PIPs at the plasma membrane
IRS-related events triggered by IGF1R
G beta:gamma signalling through PI3Kgamma
PI3K events in ERBB2 signaling
Regulation of signaling by CBL
Downstream signaling of activated FGFR
PI Metabolism
Innate Immune System
Signaling by Insulin receptor
Signalling by NGF
Insulin receptor signalling cascade
IRS-related events
Cytokine Signaling in Immune system
Signaling by Ligand-Responsive EGFR Variants in Cancer
NGF signalling via TRKA from the plasma membrane
Tie2 Signaling
Signaling by Overexpressed Wild-Type EGFR in Cancer
Cell surface interactions at the vascular wall
Signaling by FGFR
IRS-mediated signalling
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
GPVI-mediated activation cascade
Interleukin receptor SHC signaling
PI3K Cascade
Drugs
Diseases
GWAS
Protein-Protein Interactions
9 interactors:
CREB1
EP300
HPS5
KIAA0020
MARK4
MNAT1
OSGEP
PIK3CB
TTC19
10 interactors:
AGTR2
ALAS1
DVL3
HCK
HPS6
MME
PIK3R1
PRKCD
PRKCE
YWHAQ
Entrez ID
79803
5291
HPRD ID
08471
04234
Ensembl ID
ENSG00000166189
Uniprot IDs
Q86YV9
B4DER4
P42338
PDB IDs
Enriched GO Terms of Interacting Partners
?
G2/M Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Positive Regulation Of Viral Transcription
Regulation Of Viral Transcription
Positive Regulation Of Viral Process
Cell Cycle Process
Histone H2B Acetylation
Protein Stabilization
Posttranscriptional Regulation Of Gene Expression
Threonylcarbamoyladenosine Biosynthetic Process
Viral Process
Cell Cycle
Regulation Of Body Fluid Levels
Phosphatidylinositol-mediated Signaling
N-terminal Peptidyl-lysine Acetylation
Regulation Of Protein Stability
Notch Signaling Pathway
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response
Regulation Of Viral Process
G1/S Transition Of Mitotic Cell Cycle
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Mitotic Cell Cycle Process
Circadian Rhythm
Threonylcarbamoyladenosine Metabolic Process
Regulation Of Tubulin Deacetylation
Cellular Response To Fibroblast Growth Factor Stimulus
Mitotic Cell Cycle
Response To Fibroblast Growth Factor
Neurotrophin TRK Receptor Signaling Pathway
Innate Immune Response
Neurotrophin Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Organelle Organization
Phosphorylation
Negative Regulation Of Transcription By Competitive Promoter Binding
Lung Development
Positive Regulation By Host Of Viral Transcription
Embryonic Cleavage
Mitochondrial Respiratory Chain Complex III Assembly
Respiratory Tube Development
Regulation Of Cellular Protein Metabolic Process
Response To Hormone
Fc Receptor Signaling Pathway
N-terminal Protein Amino Acid Acetylation
Response To Stress
Regulation Of Clathrin-mediated Endocytosis
Lung Saccule Development
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc-gamma Receptor Signaling Pathway
Fc Receptor Mediated Stimulatory Signaling Pathway
Phagocytosis
Fc Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Signal Transduction
Positive Regulation Of Transport
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin
Regulation Of Receptor Activity
Blood Coagulation
Hemostasis
Immune Response-regulating Signaling Pathway
Intracellular Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Cellular Response To Organic Substance
Fibroblast Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin
Regulation Of Cellular Component Organization
Regulation Of Actin Filament Polymerization
Positive Regulation Of Lipid Catabolic Process
Intrinsic Apoptotic Signaling Pathway
Cellular Response To Fibroblast Growth Factor Stimulus
Exploration Behavior
Platelet Activation
Response To Fibroblast Growth Factor
Regulation Of Body Fluid Levels
Positive Regulation Of Apoptotic Signaling Pathway
Regulation Of Actin Polymerization Or Depolymerization
Regulation Of Actin Filament Length
Wound Healing
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Positive Regulation Of Immune Response
Endocytosis
Defense Response
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Lipopolysaccharide-mediated Signaling Pathway
Regulation Of Establishment Of Protein Localization
Response To Wounding
Cellular Localization
Regulation Of Apoptotic Process
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Dephosphorylation
Activation Of Phospholipase C Activity
Response To Organic Substance
Regulation Of Lipid Metabolic Process
Regulation Of Protein Localization
Tagcloud
?
amico
atm
dissect
entered
erg
formalin
fusions
hiseq
illumina
map2k5
maximise
mek5
men1
nbpf10
ncor2
needle
ngs
opening
qiagen
read
routinely
screen
sections
spop
technologies
templates
tmprrs2
unstained
yielded
Tagcloud (Difference)
?
amico
atm
dissect
entered
erg
formalin
fusions
hiseq
illumina
map2k5
maximise
mek5
men1
nbpf10
ncor2
needle
ngs
opening
qiagen
read
routinely
screen
sections
spop
technologies
templates
tmprrs2
unstained
yielded
Tagcloud (Intersection)
?