ALG9 and VPS11

		ALG9	VPS11
Description		ALG9 alpha-1,2-mannosyltransferase	VPS11 core subunit of CORVET and HOPS complexes
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Lumenal Side Of Endoplasmic Reticulum Membrane	Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Autophagosome Endosome Membrane Membrane Clathrin-coated Vesicle Endocytic Vesicle HOPS Complex Cytoplasmic Vesicle Late Endosome Membrane CORVET Complex Vesicle Tethering Complex
	Molecular Function	Alpha-1,2-mannosyltransferase Activity Transferase Activity Glycosyltransferase Activity Dol-P-Man:Man(8)GlcNAc(2)-PP-Dol Alpha-1,2-mannosyltransferase Activity Dol-P-Man:Man(6)GlcNAc(2)-PP-Dol Alpha-1,2-mannosyltransferase Activity	Nucleotide Binding Protein Binding Zinc Ion Binding Protein Domain Specific Binding Syntaxin Binding Protein-macromolecule Adaptor Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Glycosylation Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Autophagy Endosome Organization Vacuole Organization Endosome To Lysosome Transport Protein Transport Vesicle-mediated Transport Protein Ubiquitination Regulation Of Protein Stability Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Endosomal Vesicle Fusion Regulation Of SNARE Complex Assembly Positive Regulation Of Protein Catabolic Process Organelle Fusion Regulation Of Organelle Assembly Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Early Endosome To Late Endosome Transport
Pathways		Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes CDG-1l	SARS-CoV-2 modulates autophagy
Drugs
Diseases		Congenital disorders of glycosylation (CDG) type I
GWAS		A body shape index ( 34021172) Asthma or allergic disease (pleiotropy) ( 29785011) Brain morphology (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Adult body size ( 32376654) Body mass index ( 29273807) Coronary artery disease ( 29212778 33020668) HDL cholesterol levels ( 32203549) Plateletcrit ( 32888494)
Interacting Genes		2 interacting genes: BHMT H2AX	33 interacting genes: BCAR1 BMI1 ECPAS EZR GGA3 GRSF1 KDM1A KRTAP10-3 KRTAP10-8 LRSAM1 LSM1 MARK3 MON1B MSN RAB7A RDX RILP RNF181 STX1A STX6 STX7 STX8 TFAP2B TRIM32 TSG101 UBE2D2 UBE2L3 UBE2U UVRAG VPS16 VPS18 VPS33A VPS45
Entrez ID		79796	55823
HPRD ID		09504	12258
Ensembl ID		ENSG00000086848	ENSG00000160695
Uniprot IDs		Q9H6U8	A0A087WXL6 B7Z879 Q9H270
PDB IDs
Enriched GO Terms of Interacting Partners?		Betaine-homocysteine S-methyltransferase Activity Regulation Of Homocysteine Metabolic Process 'de Novo' L-methionine Biosynthetic Process S-methyltransferase Activity Amino-acid Betaine Catabolic Process Vesicle Tethering Complex Protein Modification Process L-methionine Salvage CORVET Complex Methionine Biosynthetic Process Amino-acid Betaine Metabolic Process Sulfur Amino Acid Biosynthetic Process S-adenosylmethionine Metabolic Process Methionine Metabolic Process XY Body Chromatin-protein Adaptor Activity Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway HOPS Complex Protein Ubiquitination Protein Localization To Site Of Double-strand Break Protein Modification By Small Protein Conjugation Protein Metabolic Process Replication Fork Modified Amino Acid Catabolic Process Protein Methylation Sulfur Amino Acid Metabolic Process Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Protein Targeting To Mitochondrion Aspartate Family Amino Acid Metabolic Process Post-translational Protein Modification Site Of DNA Damage Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Vesicle Docking Involved In Exocytosis Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Protein Targeting To Mitochondrion Condensed Nuclear Chromosome Male Germ Cell Nucleus Syntaxin Binding Endosome To Lysosome Transport	Late Endosome Membrane Docking Vesicle Organization Organelle Membrane Fusion Vesicle Fusion Organelle Fusion Endosome Vesicle-mediated Transport Intracellular Protein Transport Membrane Fusion Early Endosome Vacuolar Transport Endosome To Lysosome Transport Intracellular Protein Localization Lysosomal Transport Positive Regulation Of Catabolic Process Establishment Of Protein Localization Protein Transport Organelle Localization Macromolecule Catabolic Process Catabolic Process Vesicle Docking SNARE Binding Regulation Of Protein Localization Positive Regulation Of Protein Catabolic Process Cellular Localization Chloride Channel Inhibitor Activity CORVET Complex Clathrin-coated Vesicle Intracellular Transport Organelle Localization By Membrane Tethering Positive Regulation Of Early Endosome To Late Endosome Transport Autophagosome Membrane Organization Endosome Organization Late Endosome Membrane Positive Regulation Of Protein Localization To Early Endosome SNAP Receptor Activity Endosomal Transport Positive Regulation Of Protein Localization To Endosome Establishment Of Localization In Cell Endosome Membrane SNARE Complex HOPS Complex Autophagy Autophagosome Maturation Syntaxin Binding Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Positive Regulation Of Protein Metabolic Process
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