ALG9

Description		ALG9 alpha-1,2-mannosyltransferase
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Alpha-1,2-mannosyltransferase Activity Transferase Activity Glycosyltransferase Activity Dol-P-Man:Man(8)GlcNAc(2)-PP-Dol Alpha-1,2-mannosyltransferase Activity Dol-P-Man:Man(6)GlcNAc(2)-PP-Dol Alpha-1,2-mannosyltransferase Activity
	Biological Process	Protein Glycosylation Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process
Pathways		Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes CDG-1l
Drugs
Diseases		Congenital disorders of glycosylation (CDG) type I
GWAS		A body shape index ( 34021172) Asthma or allergic disease (pleiotropy) ( 29785011) Brain morphology (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Novel Interacting Genes		1 novel interacting genes: VPS11
Interacting Genes		2 interacting genes: BHMT H2AX
Entrez ID		79796
HPRD ID		09504
Ensembl ID		ENSG00000086848
Uniprot IDs		Q9H6U8
PDB IDs
Enriched GO Terms of Interacting Partners?		Betaine-homocysteine S-methyltransferase Activity Regulation Of Homocysteine Metabolic Process 'de Novo' L-methionine Biosynthetic Process S-methyltransferase Activity Amino-acid Betaine Catabolic Process Vesicle Tethering Complex Protein Modification Process L-methionine Salvage CORVET Complex Methionine Biosynthetic Process Amino-acid Betaine Metabolic Process Sulfur Amino Acid Biosynthetic Process S-adenosylmethionine Metabolic Process Methionine Metabolic Process XY Body Chromatin-protein Adaptor Activity Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway HOPS Complex Protein Ubiquitination Protein Localization To Site Of Double-strand Break Protein Modification By Small Protein Conjugation Protein Metabolic Process Replication Fork Modified Amino Acid Catabolic Process Protein Methylation Sulfur Amino Acid Metabolic Process Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Protein Targeting To Mitochondrion Aspartate Family Amino Acid Metabolic Process Post-translational Protein Modification Site Of DNA Damage Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Vesicle Docking Involved In Exocytosis Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Protein Targeting To Mitochondrion Condensed Nuclear Chromosome Male Germ Cell Nucleus Syntaxin Binding Endosome To Lysosome Transport
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