Wiki-Pi
Answer Survey
Home
About
Help
Advanced Search
ALG9 and H2AFX
Number of citations of the paper that reports this interaction (PMID
14519663
)
21
Data Source:
HPRD
(in vivo)
ALG9
H2AFX
Gene Name
ALG9, alpha-1,2-mannosyltransferase
H2A histone family, member X
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Membrane
Integral Component Of Membrane
Chromosome, Telomeric Region
Nucleosome
Nuclear Chromatin
Condensed Nuclear Chromosome
Male Germ Cell Nucleus
XY Body
Nucleus
Nucleoplasm
Replication Fork
Site Of Double-strand Break
Extracellular Vesicular Exosome
Molecular Function
Mannosyltransferase Activity
Dol-P-Man:Man(8)GlcNAc(2)-PP-Dol Alpha-1,2-mannosyltransferase Activity
Dol-P-Man:Man(6)GlcNAc(2)-PP-Dol Alpha-1,2-mannosyltransferase Activity
DNA Binding
Damaged DNA Binding
Protein Binding
Enzyme Binding
Histone Binding
Protein Heterodimerization Activity
Biological Process
Dolichol-linked Oligosaccharide Biosynthetic Process
Protein N-linked Glycosylation Via Asparagine
Post-translational Protein Modification
Cellular Protein Metabolic Process
Mannosylation
DNA Damage Checkpoint
Double-strand Break Repair Via Homologous Recombination
DNA Repair
Double-strand Break Repair
Nucleosome Assembly
Cellular Response To DNA Damage Stimulus
Spermatogenesis
Response To Ionizing Radiation
Positive Regulation Of DNA Repair
Meiotic Cell Cycle
Pathways
Defective ALG2 causes ALG2-CDG (CDG-1i)
Diseases of glycosylation
Defective ALG3 causes ALG3-CDG (CDG-1d)
Post-translational protein modification
Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
Defective ALG1 causes ALG1-CDG (CDG-1k)
Defective MGAT2 causes MGAT2-CDG (CDG-2a)
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Defective MOGS causes MOGS-CDG (CDG-2b)
Defective ALG6 causes ALG6-CDG (CDG-1c)
Defective RFT1 causes RFT1-CDG (CDG-1n)
Asparagine N-linked glycosylation
Defective ALG8 causes ALG8-CDG (CDG-1h)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Defective ALG9 causes ALG9-CDG (CDG-1l)
Defective MAN1B1 causes MRT15
Defective MPDU1 causes MPDU1-CDG (CDG-1f)
Defective ALG12 causes ALG12-CDG (CDG-1g)
Defective ALG11 causes ALG11-CDG (CDG-1p)
Diseases associated with N-glycosylation of proteins
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
Regulatory RNA pathways
Deposition of new CENPA-containing nucleosomes at the centromere
Cellular Senescence
Signaling by Wnt
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
RNF mutants show enhanced WNT signaling and proliferation
Homologous recombination repair of replication-independent double-strand breaks
ATM mediated phosphorylation of repair proteins
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
ATM mediated response to DNA double-strand break
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
Chromatin organization
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Senescence-Associated Secretory Phenotype (SASP)
Chromatin modifying enzymes
Recruitment of repair and signaling proteins to double-strand breaks
SIRT1 negatively regulates rRNA Expression
Condensation of Prophase Chromosomes
MRN complex relocalizes to nuclear foci
RNA Polymerase I Promoter Clearance
Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks
M Phase
Telomere Maintenance
Nucleosome assembly
XAV939 inhibits tankyrase, stabilizing AXIN
Double-Strand Break Repair
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
RNA Polymerase I Transcription
Epigenetic regulation of gene expression
Negative epigenetic regulation of rRNA expression
Cell Cycle, Mitotic
PRC2 methylates histones and DNA
RMTs methylate histone arginines
TCF dependent signaling in response to WNT
Oxidative Stress Induced Senescence
Homologous Recombination Repair
RNA Polymerase I Promoter Opening
Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions
2 interactors:
BHMT
H2AFX
45 interactors:
A2M
ACTB
ALG9
ATM
ATR
BARD1
BMI1
BRCA1
BRCA2
BRD1
CALM1
COPG1
DDX21
DHX9
KAT5
MASP1
MCPH1
MDC1
MRE11A
NBN
NCL
NGFR
OTUB1
PAXIP1
PBK
PPP1CA
PPP2R4
PRKDC
QARS
RNF168
RNF8
RPS6KA3
SMARCA4
SSRP1
SUPT16H
SUPT5H
TAF1C
TAF5L
TERF2
TIAM2
TOPORS
TP53BP1
TSSK6
WRN
XRCC6
Entrez ID
79796
3014
HPRD ID
09504
03465
Ensembl ID
ENSG00000188486
Uniprot IDs
Q9H6U8
P16104
PDB IDs
2D31
2DYP
3SHV
3SQD
3SZM
3U3Z
Enriched GO Terms of Interacting Partners
?
S-methylmethionine Cycle
S-methylmethionine Metabolic Process
Amino-acid Betaine Catabolic Process
Regulation Of Homocysteine Metabolic Process
L-methionine Salvage
Methionine Biosynthetic Process
Amino-acid Betaine Metabolic Process
Methionine Metabolic Process
Sulfur Amino Acid Biosynthetic Process
Positive Regulation Of DNA Repair
Sulfur Amino Acid Metabolic Process
Regulation Of DNA Repair
Positive Regulation Of Response To DNA Damage Stimulus
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
Nucleosome Assembly
Regulation Of Response To DNA Damage Stimulus
Cellular Amino Acid Biosynthetic Process
Chromatin Assembly
Nucleosome Organization
Response To Ionizing Radiation
Positive Regulation Of DNA Metabolic Process
Double-strand Break Repair
Chromatin Assembly Or Disassembly
DNA Damage Checkpoint
Protein-DNA Complex Assembly
Protein Methylation
DNA Packaging
DNA Metabolic Process
Double-strand Break Repair
DNA Repair
Cellular Response To DNA Damage Stimulus
Chromosome Organization
DNA Recombination
Organelle Organization
Cellular Response To Stress
Response To Ionizing Radiation
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
Response To Radiation
Chromatin Organization
Response To Stress
Regulation Of Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Chromatin Modification
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Response To Abiotic Stimulus
Telomere Maintenance
Nitrogen Compound Metabolic Process
Positive Regulation Of Metabolic Process
Cell Cycle
Positive Regulation Of Cellular Metabolic Process
Signal Transduction In Response To DNA Damage
Regulation Of Protein Metabolic Process
Cellular Metabolic Process
Histone Modification
Signal Transduction By P53 Class Mediator
Response To Stimulus
Negative Regulation Of Cell Cycle
Regulation Of Cell Cycle
Cellular Response To Stimulus
Cellular Protein Modification Process
DNA Damage Response, Signal Transduction By P53 Class Mediator
Regulation Of Nitrogen Compound Metabolic Process
Peptidyl-amino Acid Modification
DNA Damage Checkpoint
Peptidyl-lysine Modification
Cell Cycle Process
Regulation Of Cellular Protein Metabolic Process
DNA Replication
Regulation Of Gene Expression
Response To Gamma Radiation
Negative Regulation Of Protein Metabolic Process
Histone Acetylation
Double-strand Break Repair Via Nonhomologous End Joining
Tagcloud
?
adbrk2
arntl
dpysl2
drd3
dusp6
famine
gad1
gch1
gnaz
grin1
grin2b
gsk3b
hip1r
homoeostasis
hspa5
impa2
kcnq2
per3
pik3c3
pip5k2a
plcg1
rgs4
shuts
slc6a3
slc6a4
sybl1
synj1
timeless
wfs1
Tagcloud (Difference)
?
adbrk2
arntl
dpysl2
drd3
dusp6
famine
gad1
gch1
gnaz
grin1
grin2b
gsk3b
hip1r
homoeostasis
hspa5
impa2
kcnq2
per3
pik3c3
pip5k2a
plcg1
rgs4
shuts
slc6a3
slc6a4
sybl1
synj1
timeless
wfs1
Tagcloud (Intersection)
?