CLMN and FHL1

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		CLMN	FHL1
Description		calmin	four and a half LIM domains 1
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Outer Membrane Cytoplasm Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion
	Molecular Function	Actin Binding Actin Filament Binding	Protein Binding Zinc Ion Binding Transmembrane Transporter Binding Metal Ion Binding Channel Activator Activity Potassium Channel Activator Activity
	Biological Process	Nuclear Migration Negative Regulation Of Cell Population Proliferation Neuron Projection Development	Muscle Organ Development Animal Organ Morphogenesis Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Differentiation Negative Regulation Of Cell Growth Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Positive Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Drugs
Diseases			X-linked myopathy with postural muscle atrophy (XMPMA) Scapuloperoneal myopathy (SPM) Reducing body myopathy (RBM) Emery-Dreifuss muscular dystrophy
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Body mass index ( 25760438) Breast size ( 22747683) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Gut microbiota (functional units) ( 27694959) Metabolite levels ( 23823483) Response to antipsychotic treatment ( 20195266) Response to statin therapy ( 20339536) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		3 interacting genes: FHL1 MTDH PPP1CC	30 interacting genes: APP CBX4 CHEK2 CLMN CSRP3 DBN1 DEAF1 DOCK9 EED ENO1 FHL2 HES1 HIVEP3 IGFBP5 LAMA4 MACF1 MYBPC1 NFIL3 PAX7 PDE4DIP PDLIM3 RBPJ RING1 SRF SRPK1 TTN TXNIP USP15 YWHAE ZBTB40
Entrez ID		79789	2273
HPRD ID		13076	02157
Ensembl ID		ENSG00000165959	ENSG00000022267
Uniprot IDs		Q6NUQ2 Q96JQ2	B7Z9A1 Q13642 Q5JXI2
PDB IDs			1X63 2CUP 2CUR 2EGQ
Enriched GO Terms of Interacting Partners?			Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Sarcomere Organization Structural Constituent Of Muscle Negative Regulation Of RNA Metabolic Process Cardiac Myofibril Assembly Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Developmental Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleus M Band Aorta Morphogenesis Chromatin Binding Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Supramolecular Fiber Organization Myofibril Assembly Developmental Process Negative Regulation Of Macromolecule Biosynthetic Process Actin Binding Actomyosin Structure Organization Negative Regulation Of Biosynthetic Process Sex Chromatin Detection Of Muscle Stretch Telethonin Binding Cell Differentiation Negative Regulation Of Metabolic Process Transcription Corepressor Binding Z Disc Dorsal Aorta Morphogenesis Cardiac Muscle Cell Myoblast Differentiation Negative Regulation Of Macromolecule Metabolic Process Artery Morphogenesis Cadherin Binding Regulation Of Timing Of Cell Differentiation Cardioblast Differentiation Cytoskeleton Organization Heart Trabecula Formation Regulation Of Development, Heterochronic Actinin Binding Muscle Tissue Morphogenesis Muscle Alpha-actinin Binding
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