MICALL2 and ACTN3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MICALL2	ACTN3
Description		MICAL like 2	actinin alpha 3
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Endosome Cytoskeleton Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Actin Filament Bundle Cell Projection Neuron Projection Recycling Endosome Anchoring Junction	Cytoplasm Cytosol Actin Filament Plasma Membrane Brush Border Focal Adhesion Actin Cytoskeleton Sarcomere Z Disc Cell Junction Cortical Actin Cytoskeleton Pseudopodium Cell Projection Extracellular Exosome
	Molecular Function	Protein Binding Filamin Binding Small GTPase Binding Actinin Binding Metal Ion Binding Actin Filament Binding	Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Identical Protein Binding Transmembrane Transporter Binding Metal Ion Binding Actin Filament Binding
	Biological Process	Actin Cytoskeleton Organization Actin Filament Polymerization Neuron Projection Development Endocytic Recycling Rab Protein Signal Transduction Substrate Adhesion-dependent Cell Spreading Bicellular Tight Junction Assembly Endosome Membrane Tubulation Positive Regulation Of Protein Targeting To Mitochondrion	Regulation Of The Force Of Skeletal Muscle Contraction Skeletal Muscle Atrophy Transition Between Fast And Slow Fiber Response To Denervation Involved In Regulation Of Muscle Adaptation Actin Cytoskeleton Organization Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Regulation Of Apoptotic Process Negative Regulation Of Glycolytic Process Focal Adhesion Assembly Positive Regulation Of Skeletal Muscle Tissue Growth Positive Regulation Of Skeletal Muscle Fiber Development Muscle Cell Development Bone Morphogenesis Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Muscle System Process Negative Regulation Of Oxidative Phosphorylation Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Bone Mineralization Involved In Bone Maturation Negative Regulation Of Relaxation Of Muscle Regulation Of Aerobic Respiration Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate
Pathways			Nephrin family interactions Striated Muscle Contraction
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 29403010) Creatinine levels ( 29403010) Executive inhibition (Stroop WIT and CIT) in attention deficit hyperactivity disorder ( 28416812) Glomerular filtration rate ( 29403010) Hematocrit ( 29403010) Hemoglobin ( 29403010) Red blood cell count ( 29403010) Resistance to antihypertensive treatment in hypertension ( 31545351) Restless legs syndrome ( 33239738) Serum uric acid levels ( 29403010 30993211) Zinc levels ( 26025379)	Bipolar disorder ( 21926972) Frontotemporal dementia with GRN mutation ( 29724592)
Interacting Genes		6 interacting genes: ACTN1 ACTN2 ACTN3 ACTN4 CDR2 DCDC2	61 interacting genes: ABI3 ACTN1 ACTN2 ACTN4 ADORA2A ASB9 ATP23 BRCA1 C1orf94 CADPS CATSPERT CIMAP1B CIMIP1 CTAG1A CTAG1B CTDSP1 CXCL5 DDAH2 DUX1 DUX4L9 ECM1 FAM90A1 GLIS2 HGS HOXD12 HSF2BP IVD KCTD6 KRT6C LHX3 LINC01554 LNX1 MAGEA6 MICALL2 MYOT MYOZ1 MYPN NDUFAB1 NEBL NKAPD1 NRAP PCCB PKP2 PLEKHG2 POU6F2 PPP1R18 PTK6 REL RNF111 RTP5 SNAI1 SOHLH1 SUMO1P1 SYNPO2L TRAF1 TRAF2 TRIM29 TTN USP2 ZNF343 ZNF426
Entrez ID		79778	89
HPRD ID		11364	02148
Ensembl ID		ENSG00000164877	ENSG00000248746
Uniprot IDs		Q8IY33	A0A087WSZ2 B4DZQ2 Q08043
PDB IDs			1TJT 1WKU 3LUE
Enriched GO Terms of Interacting Partners?		Pseudopodium Cortical Actin Cytoskeleton Muscle Cell Development Transmembrane Transporter Binding Integrin Binding Z Disc Focal Adhesion Assembly Actin Filament Binding Cell Junction Cell-substrate Junction Organization Cell-substrate Junction Assembly Sarcomere Platelet Alpha Granule Lumen Actin Cytoskeleton Actin Filament Actin Cytoskeleton Organization Actin Binding Actin Filament-based Process Postsynaptic Actin Cytoskeleton Focal Adhesion Cell Projection Calcium Ion Binding Positive Regulation Of Ion Transmembrane Transporter Activity Cell Junction Assembly Positive Regulation Of Transporter Activity Transcription Coactivator Activity Cell Development Structural Constituent Of Muscle Cytoskeleton Organization Brush Border Cytoskeletal Protein Binding Organelle Organization Regulation Of Transmembrane Transporter Activity Regulation Of Monoatomic Ion Transmembrane Transporter Activity Stress Fiber Cell Junction Organization Actin Filament Uncapping Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Cytoskeleton Positive Regulation Of Cation Transmembrane Transport Structural Constituent Of Postsynapse Titin Z Domain Binding Regulation Of The Force Of Skeletal Muscle Contraction Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Monoatomic Ion Transmembrane Transport Nucleoside Binding Positive Regulation Of Sodium:proton Antiporter Activity Platelet Morphogenesis	Z Disc Pseudopodium Sarcomere Organization Actin Filament Binding Actin Binding Identical Protein Binding Cytoskeletal Protein Binding Actin Cytoskeleton Organization Actin Filament-based Process Structural Constituent Of Muscle Actinin Binding Muscle Alpha-actinin Binding Protein Binding Cardiac Muscle Thin Filament Assembly Actomyosin Structure Organization Actin Cytoskeleton I Band FATZ Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cytoskeleton Organization Telethonin Binding Stress Fiber Fascia Adherens Supramolecular Fiber Organization Muscle Cell Development Postsynaptic Actin Cytoskeleton Thioesterase Binding
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