ISOC2 and LSM8

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
HPRD (two hybrid)

		ISOC2	LSM8
Description		isochorismatase domain containing 2	LSM8 homolog, U6 small nuclear RNA associated
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion	Nucleus Nucleoplasm Spliceosomal Complex U6 SnRNP U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome Lsm2-8 Complex Ribonucleoprotein Complex
	Molecular Function	Protein Binding	RNA Binding MRNA Binding Protein Binding U6 SnRNA Binding
	Biological Process	Protein Destabilization	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing
Pathways			mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS			Anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Glaucoma (primary open-angle) ( 29891935 33627673) Intraocular pressure ( 29617998) Plasma anti-thyroid peroxidase levels ( 29678681) Positive urgency ( 30718321) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Smoking initiation ( 33082346) Smoking status (current vs never) ( 33082346) Triglyceride levels ( 30108155)
Interacting Genes		5 interacting genes: APP CALML3 CDKN2A LSM8 PDK2	49 interacting genes: ARNT BCKDK COL23A1 DBF4 DCP1A DCP1B DPAGT1 ECHDC2 EFTUD2 EXOSC10 EXOSC6 FERMT3 GMPPA GTF2I HSPA9 IFNLR1 IGHMBP2 ISOC2 ITSN2 KCTD3 LSM2 LSM3 LSM5 LSM6 LSM7 MAPK8IP2 MGA MINDY1 MPRIP MRPL48 MTHFR NAGK NME4 PDCD2 PGD PHF11 RBM5 RPL24 RSC1A1 RSL24D1 SEPTIN10 SEPTIN5 SMU1 SNRNP200 SNRPB SNRPD1 TALDO1 THUMPD3 UPF1
Entrez ID		79763	51691
HPRD ID		08030	06288
Ensembl ID		ENSG00000063241	ENSG00000128534
Uniprot IDs		Q96AB3	A4D0W0 O95777
PDB IDs			3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 7ABG 8H6E 8H6J 8H6K 8H6L 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Regulation Of Phosphorus Metabolic Process Growth Cone Lamellipodium Regulation Of Calcium Ion Transmembrane Transport Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Intracellular Signal Transduction Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Calcium-mediated Signaling Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Amyloid Fibril Formation Regulation Of Calcium-mediated Signaling Lipoprotein Particle Regulation Of Protein Localization To Nucleus Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Macrophage Apoptotic Process Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Response To Reactive Oxygen Species Negative Regulation Of Protein Neddylation Ubiquitin-protein Transferase Inhibitor Activity Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Senescence-associated Heterochromatin Focus Ligase Inhibitor Activity Negative Regulation Of Immature T Cell Proliferation In Thymus Apoptotic Process Involved In Mammary Gland Involution Cellular Response To Reactive Oxygen Species Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway	U2-type Precatalytic Spliceosome U4/U6 X U5 Tri-snRNP Complex Lsm2-8 Complex MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions U6 SnRNP MRNA Catabolic Process Spliceosomal Complex Lsm1-7-Pat1 Complex RNA Catabolic Process RNA Splicing Catalytic Step 2 Spliceosome Nucleobase-containing Compound Metabolic Process RNA Metabolic Process MRNA Processing RNA Processing RNA Binding Ribonucleoprotein Complex Small Nuclear Ribonucleoprotein Complex Precatalytic Spliceosome P-body Nucleobase-containing Compound Catabolic Process Nuclear-transcribed MRNA Catabolic Process Nucleic Acid Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Protein-RNA Complex Assembly Double-stranded DNA Helicase Activity U5 SnRNP Positive Regulation Of MRNA Cis Splicing, Via Spliceosome U12-type Spliceosomal Complex Deadenylation-independent Decapping Of Nuclear-transcribed MRNA U2-type Catalytic Step 2 Spliceosome Spliceosomal Tri-snRNP Complex U1 SnRNP Binding Nucleoplasm Poly(A)-dependent SnoRNA 3'-end Processing 7-methylguanosine Cap Hypermethylation Spliceosomal SnRNP Assembly Regulation Of MRNA Splicing, Via Spliceosome Spliceosomal Complex Assembly Nucleolar Exosome (RNase Complex) 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity Nuclear MRNA Surveillance U4 SnRNP Methylosome Macromolecule Metabolic Process Pentose-phosphate Shunt Regulation Of MRNA Processing Septin Ring
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