ISOC2 and CALML3

Number of citations of the paper that reports this interaction (PubMedID 21516116)
20

Data Source:
BioGRID (two hybrid)

		ISOC2	CALML3
Description		isochorismatase domain containing 2	calmodulin like 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion	Cytoplasm Centrosome Synaptic Vesicle Membrane Myelin Sheath Extracellular Exosome
	Molecular Function	Protein Binding	Calcium Ion Binding Protein Binding Metal Ion Binding
	Biological Process	Protein Destabilization	Detection Of Calcium Ion Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Calcineurin-mediated Signaling
Pathways
Drugs
Diseases
GWAS			Fasting insulin ( 34074324)
Interacting Genes		5 interacting genes: APP CALML3 CDKN2A LSM8 PDK2	9 interacting genes: BHLHE40 C11orf65 IQCB1 IQCN ISOC2 MAPK4 MFHAS1 MYO10 TERF2IP
Entrez ID		79763	810
HPRD ID		08030	00244
Ensembl ID		ENSG00000063241	ENSG00000178363
Uniprot IDs		Q96AB3	P27482
PDB IDs			1GGZ
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Regulation Of Phosphorus Metabolic Process Growth Cone Lamellipodium Regulation Of Calcium Ion Transmembrane Transport Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Intracellular Signal Transduction Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Calcium-mediated Signaling Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Amyloid Fibril Formation Regulation Of Calcium-mediated Signaling Lipoprotein Particle Regulation Of Protein Localization To Nucleus Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Macrophage Apoptotic Process Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Response To Reactive Oxygen Species Negative Regulation Of Protein Neddylation Ubiquitin-protein Transferase Inhibitor Activity Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Senescence-associated Heterochromatin Focus Ligase Inhibitor Activity Negative Regulation Of Immature T Cell Proliferation In Thymus Apoptotic Process Involved In Mammary Gland Involution Cellular Response To Reactive Oxygen Species Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway
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