RAD51AP1 and DMC1

Number of citations of the paper that reports this interaction (PubMedID 21903585)
42

Data Source:
BioGRID (affinity chromatography technology, pull down, biochemical)

		RAD51AP1	DMC1
Description		RAD51 associated protein 1	DNA meiotic recombinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromosome Protein-containing Complex	Chromosome, Telomeric Region Condensed Nuclear Chromosome Lateral Element Nucleus Nucleoplasm Chromosome Site Of Double-strand Break
	Molecular Function	DNA Secondary Structure Binding DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding RNA Binding Protein Binding D-loop DNA Binding	DNA Strand Exchange Activity Nucleotide Binding DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Identical Protein Binding Catalytic Activity, Acting On DNA ATP-dependent DNA Damage Sensor Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Reciprocal Meiotic Recombination Interstrand Cross-link Repair Meiotic Cell Cycle Cellular Response To Ionizing Radiation Positive Regulation Of Double-strand Break Repair Via Homologous Recombination	Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly Ovarian Follicle Development Oocyte Maturation DNA Metabolic Process DNA Repair Mitotic Recombination Homologous Chromosome Pairing At Meiosis Reciprocal Meiotic Recombination Male Meiosis I Gamete Generation Spermatogenesis Spermatid Development Female Gamete Generation DNA Strand Invasion Oogenesis Meiotic Cell Cycle Chromosome Organization Involved In Meiotic Cell Cycle Double-strand Break Repair Involved In Meiotic Recombination
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to PALB2	Meiotic recombination Meiotic recombination
Drugs			Imidazole
Diseases
GWAS		Colorectal cancer ( 23263487) Phosphorus levels ( 20558539)	Gamma glutamyl transferase levels ( 29403010) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Menopause (age at onset) ( 26414677) Sleep duration ( 30846698)
Interacting Genes		10 interacting genes: APP ATRX DMC1 LRRK2 MAP3K1 NEDD4 NUCKS1 PALB2 RAD51 SIAH1	20 interacting genes: BRCA2 FIGNL1 FIRRM GORASP2 KCTD17 LNX1 MCPH1 MSH4 NIF3L1 PIAS2 PICK1 PSMA3 RAD51 RAD51AP1 RAD54B RPA1 SDCBP SDCBP2 TRIM23 UBE2I
Entrez ID		10635	11144
HPRD ID		04350	04099
Ensembl ID		ENSG00000111247	ENSG00000100206
Uniprot IDs		B4DUS5 F5H1Y0 Q96B01	Q14565
PDB IDs			1V5W 2ZJB 4HYY 6R3P 7C98 7C99 7C9C 7CGY 8QQE 8R2G
Enriched GO Terms of Interacting Partners?		Recombinational Repair Double-strand Break Repair Via Homologous Recombination Homologous Recombination DNA Strand Exchange Activity Replication Fork Processing DNA Damage Response DNA Strand Invasion DNA Recombinase Assembly Chromosome Organization Involved In Meiotic Cell Cycle Anatomical Structure Morphogenesis DNA Repair Double-strand Break Repair DNA Recombination Cellular Response To Manganese Ion Cellular Response To Stress Double-strand Break Repair Involved In Meiotic Recombination Cellular Response To Hydroxyurea Macromolecule Metabolic Process Response To Hydroxyurea Response To Manganese Ion Lateral Element Single-stranded DNA Binding Golgi-associated Vesicle Cellular Response To Catecholamine Stimulus DNA Metabolic Process ATP-dependent DNA Damage Sensor Activity Mitotic Recombination Response To Catecholamine Double-stranded DNA Binding Reproductive Process Perikaryon MAP Kinase Kinase Kinase Activity Response To Stress Regulation Of Membrane Potential Response To Radiation Response To X-ray Reciprocal Meiotic Recombination Calcium-mediated Signaling Amyloid Fibril Formation Cellular Response To Radiation Chromatin Binding Nuclear Chromosome Chromosome, Telomeric Region Male Gamete Generation Spermatogenesis ATP-dependent Activity, Acting On DNA Regulation Of Intrinsic Apoptotic Signaling Pathway Protein-DNA Complex Assembly Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Gamete Generation	Recombinational Repair Lateral Element Double-strand Break Repair Via Homologous Recombination Response To Ionizing Radiation DNA Recombination Mitotic Recombination-dependent Replication Fork Processing DNA Repair Mitotic Recombination Cellular Response To Ionizing Radiation Cellular Response To Stress Reciprocal Meiotic Recombination Double-strand Break Repair Nuclear Chromosome Single-stranded DNA Binding PML Body Identical Protein Binding Condensed Chromosome Meiotic Cell Cycle Homologous Recombination DNA Metabolic Process Interstrand Cross-link Repair Nuclear Ubiquitin Ligase Complex DNA Damage Response Condensed Nuclear Chromosome Cellular Response To Radiation Chromosome, Telomeric Region Reproductive Process Meiotic Nuclear Division Macromolecule Metabolic Process Telomere Maintenance Via Recombination Response To Radiation Regulation Of Double-strand Break Repair Via Homologous Recombination Nuclear Division ATP-dependent DNA Damage Sensor Activity Telomere Maintenance SUMO Transferase Activity Response To Stress Regulation Of DNA Damage Checkpoint Synaptonemal Complex Nucleoplasm Telomere Organization Response To X-ray Double-stranded DNA Binding Mismatch Repair Regulation Of DNA Recombination Telomere Maintenance Via Telomere Lengthening Chromosome Organization Nucleus Regulation Of Double-strand Break Repair Chromosome
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