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RAD51AP1
Description
RAD51 associated protein 1
Image
No pdb structure
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
Chromosome
Protein-containing Complex
Molecular Function
DNA Secondary Structure Binding
DNA Binding
Double-stranded DNA Binding
Single-stranded DNA Binding
RNA Binding
Protein Binding
D-loop DNA Binding
Biological Process
Double-strand Break Repair Via Homologous Recombination
DNA Repair
DNA Recombination
DNA Damage Response
Regulation Of Double-strand Break Repair Via Homologous Recombination
Positive Regulation Of Reciprocal Meiotic Recombination
Interstrand Cross-link Repair
Meiotic Cell Cycle
Cellular Response To Ionizing Radiation
Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Defective homologous recombination repair (HRR) due to BRCA1 loss of function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Impaired BRCA2 binding to PALB2
Drugs
Diseases
GWAS
Colorectal cancer (
23263487
)
Phosphorus levels (
20558539
)
Novel Interacting Genes
1 novel interacting genes:
CACNA1C
Interacting Genes
10 interacting genes:
APP
ATRX
DMC1
LRRK2
MAP3K1
NEDD4
NUCKS1
PALB2
RAD51
SIAH1
Entrez ID
10635
HPRD ID
04350
Ensembl ID
ENSG00000111247
Uniprot IDs
B4DUS5
F5H1Y0
Q96B01
PDB IDs
Enriched GO Terms of Interacting Partners
?
Recombinational Repair
Double-strand Break Repair Via Homologous Recombination
Homologous Recombination
DNA Strand Exchange Activity
Replication Fork Processing
DNA Damage Response
DNA Strand Invasion
DNA Recombinase Assembly
Chromosome Organization Involved In Meiotic Cell Cycle
Anatomical Structure Morphogenesis
DNA Repair
Double-strand Break Repair
DNA Recombination
Cellular Response To Manganese Ion
Cellular Response To Stress
Double-strand Break Repair Involved In Meiotic Recombination
Cellular Response To Hydroxyurea
Macromolecule Metabolic Process
Response To Hydroxyurea
Response To Manganese Ion
Lateral Element
Single-stranded DNA Binding
Golgi-associated Vesicle
Cellular Response To Catecholamine Stimulus
DNA Metabolic Process
ATP-dependent DNA Damage Sensor Activity
Mitotic Recombination
Response To Catecholamine
Double-stranded DNA Binding
Reproductive Process
Perikaryon
MAP Kinase Kinase Kinase Activity
Response To Stress
Regulation Of Membrane Potential
Response To Radiation
Response To X-ray
Reciprocal Meiotic Recombination
Calcium-mediated Signaling
Amyloid Fibril Formation
Cellular Response To Radiation
Chromatin Binding
Nuclear Chromosome
Chromosome, Telomeric Region
Male Gamete Generation
Spermatogenesis
ATP-dependent Activity, Acting On DNA
Regulation Of Intrinsic Apoptotic Signaling Pathway
Protein-DNA Complex Assembly
Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Gamete Generation
Tagcloud
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