RAD51AP1 and NUCKS1

Number of citations of the paper that reports this interaction (PubMedID 32876692)
71

Data Source:
BioGRID (pull down)

		RAD51AP1	NUCKS1
Description		RAD51 associated protein 1	nuclear casein kinase and cyclin dependent kinase substrate 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromosome Protein-containing Complex	Chromatin Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm
	Molecular Function	DNA Secondary Structure Binding DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding RNA Binding Protein Binding D-loop DNA Binding	Chromatin Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding DNA-binding Transcription Factor Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Reciprocal Meiotic Recombination Interstrand Cross-link Repair Meiotic Cell Cycle Cellular Response To Ionizing Radiation Positive Regulation Of Double-strand Break Repair Via Homologous Recombination	Double-strand Break Repair Via Homologous Recombination Intracellular Glucose Homeostasis Regulation Of DNA Replication DNA Repair Chromatin Organization DNA Damage Response Replication Fork Processing Gene Conversion Interstrand Cross-link Repair Glucose Homeostasis Host-mediated Activation Of Viral Transcription Host-mediated Perturbation Of Viral Genome Replication Host-mediated Activation Of Viral Genome Replication Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Insulin Receptor Signaling Pathway Regulation Of DNA Strand Elongation Cellular Response To X-ray
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to PALB2
Drugs
Diseases
GWAS		Colorectal cancer ( 23263487) Phosphorus levels ( 20558539)	Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Atrial fibrillation ( 29892015 30061737) Body mass index ( 28892062) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Free thyroxine concentration ( 30367059) HDL cholesterol levels ( 32203549) Menarche (age at onset) ( 25231870) Parkinson's disease ( 19915576 32201043 28892059 27182965 25064009 19915575) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Posterior thalamic nuclei volume ( 34006833) Prostate-specific antigen levels ( 25434496 23269536) Pubertal anthropometrics ( 23449627) QT interval ( 24952745) Serum alkaline phosphatase levels ( 33547301) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Weight ( 28552196)
Interacting Genes		10 interacting genes: APP ATRX DMC1 LRRK2 MAP3K1 NEDD4 NUCKS1 PALB2 RAD51 SIAH1	6 interacting genes: AK5 CEBPA DOCK9 GLP1R MDM2 RAD51AP1
Entrez ID		10635	64710
HPRD ID		04350	11406
Ensembl ID		ENSG00000111247	ENSG00000069275
Uniprot IDs		B4DUS5 F5H1Y0 Q96B01	Q9H1E3
PDB IDs
Enriched GO Terms of Interacting Partners?		Recombinational Repair Double-strand Break Repair Via Homologous Recombination Homologous Recombination DNA Strand Exchange Activity Replication Fork Processing DNA Damage Response DNA Strand Invasion DNA Recombinase Assembly Chromosome Organization Involved In Meiotic Cell Cycle Anatomical Structure Morphogenesis DNA Repair Double-strand Break Repair DNA Recombination Cellular Response To Manganese Ion Cellular Response To Stress Double-strand Break Repair Involved In Meiotic Recombination Cellular Response To Hydroxyurea Macromolecule Metabolic Process Response To Hydroxyurea Response To Manganese Ion Lateral Element Single-stranded DNA Binding Golgi-associated Vesicle Cellular Response To Catecholamine Stimulus DNA Metabolic Process ATP-dependent DNA Damage Sensor Activity Mitotic Recombination Response To Catecholamine Double-stranded DNA Binding Reproductive Process Perikaryon MAP Kinase Kinase Kinase Activity Response To Stress Regulation Of Membrane Potential Response To Radiation Response To X-ray Reciprocal Meiotic Recombination Calcium-mediated Signaling Amyloid Fibril Formation Cellular Response To Radiation Chromatin Binding Nuclear Chromosome Chromosome, Telomeric Region Male Gamete Generation Spermatogenesis ATP-dependent Activity, Acting On DNA Regulation Of Intrinsic Apoptotic Signaling Pathway Protein-DNA Complex Assembly Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Gamete Generation	Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process CHOP-C/EBP Complex Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Response To Vitamin RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Response To Vitamin B2 C/EBP Complex Response To Hormone Positive Regulation Of Proteasomal Protein Catabolic Process Glucagon-like Peptide 1 Receptor Activity Glucagon Receptor Activity Response To Vitamin B1 Response To Water-immersion Restraint Stress Cellular Response To Ionizing Radiation Response To Formaldehyde Cellular Response To Vitamin B1 Response To Ionizing Radiation Cellular Response To Actinomycin D Centriolar Satellite D-loop DNA Binding Positive Regulation Of Reciprocal Meiotic Recombination DADP Biosynthetic Process Response To Nutrient Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein-containing Complex White Fat Cell Proliferation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Response To Psychosocial Stress Cellular Response To Peptide Hormone Stimulus NEDD8 Ligase Activity Response To Actinomycin D Cellular Response To Radiation Traversing Start Control Point Of Mitotic Cell Cycle Cellular Response To UV-C Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission DNA Secondary Structure Binding ADP Biosynthetic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Heart Contraction Receptor Serine/threonine Kinase Binding Positive Regulation Of Protein Catabolic Process Response To Steroid Hormone Response To Phenylpropanoid Protein Domain Specific Binding Fat Cell Proliferation Post-translational Protein Targeting To Membrane, Translocation
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