ZNF746 and ZNF777

Number of citations of the paper that reports this interaction (PubMedID 31856708)
65

Data Source:
BioGRID (pull down)

		ZNF746	ZNF777
Description		zinc finger protein 746	zinc finger protein 777
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein Homooligomerization Protein Heterooligomerization	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Negative Regulation Of DNA-templated Transcription Protein Heterooligomerization
Pathways		Generic Transcription Pathway	Generic Transcription Pathway
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 19451621) Multiple sclerosis ( 21833088)
Interacting Genes		15 interacting genes: DIABLO DUSP23 EPHA8 FAM118B FES GSK3B HMOX2 ILK MAP3K20 MAP3K7 PRKN PRKRA RPS6KA6 UBE2E3 ZNF777	9 interacting genes: CCDC136 CEP70 CLK3 FSD2 IL16 KIAA0753 KRTAP10-9 TFIP11 ZNF746
Entrez ID		155061	27153
HPRD ID		08099	13849
Ensembl ID		ENSG00000181220	ENSG00000196453
Uniprot IDs		A0A2R8YDQ5 A0A8J9FQ52 Q6NUN9	Q9ULD5
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity ATP Binding Kinase Activity Protein Serine/threonine Kinase Activity Nucleotide Binding Positive Regulation Of Intracellular Signal Transduction Transferase Activity Magnesium Ion Binding Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Protein Phosphorylation Protein Autophosphorylation Protein Serine Kinase Activity P38MAPK Cascade Stress-activated MAPK Cascade MAP Kinase Kinase Kinase Activity Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Gene Expression Phosphorylation Signal Transduction In Response To DNA Damage Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Autophagy Protein Kinase Binding Protein K11-linked Ubiquitination Protein Kinase Activator Activity Regulation Of Microtubule Anchoring At Centrosome Negative Regulation Of Spontaneous Neurotransmitter Secretion Positive Regulation Of Mitotic DNA Damage Checkpoint Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Modification Process Cytosol Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Stress Superior Temporal Gyrus Development Negative Regulation Of Type B Pancreatic Cell Development SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Biosynthetic Process Negative Regulation Of Glycogen (starch) Synthase Activity Scaffold Protein Binding Heme Oxidation Heme Oxygenase (decyclizing) Activity Positive Regulation Of Retrograde Transport, Endosome To Golgi Protein Monoubiquitination Negative Regulation Of Intralumenal Vesicle Formation
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