ZNF746 and DUSP23

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		ZNF746	DUSP23
Gene Name		zinc finger protein 746	dual specificity phosphatase 23
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Cytosol Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Ubiquitin Protein Ligase Binding Transcription Regulatory Region DNA Binding Metal Ion Binding	Protein Tyrosine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Neuron Death	Peptidyl-tyrosine Dephosphorylation
Pathways		Generic Transcription Pathway
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 19451621) Multiple sclerosis ( 21833088)	C-reactive protein ( 22939635) Interstitial lung disease ( 21787189)
Protein-Protein Interactions		13 interactors: DIABLO DUSP23 EPHA8 FAM118B FES GSK3B HMOX2 ILK MAP3K7 PARK2 PRKRA RPS6KA6 ZAK	24 interactors: ASB13 CCDC186 DBI DBN1 DNMT3B EDRF1 EED EXOSC8 GCM1 KAT5 KBTBD7 KIAA1377 MKRN1 MRPL20 MTFR1 NIF3L1 PRDX4 RPL8 RUFY2 SHC1 SMPD1 TMOD3 TUBA1A ZNF746
Entrez ID		155061	54935
HPRD ID		08099	07908
Ensembl ID		ENSG00000181220	ENSG00000158716
Uniprot IDs		Q6NUN9	Q9BVJ7
PDB IDs			2IMG 4ERC
Enriched GO Terms of Interacting Partners?		Regulation Of MAPK Cascade Protein Phosphorylation Cellular Protein Modification Process Response To Stress Regulation Of Intracellular Signal Transduction Phosphorylation Positive Regulation Of Signal Transduction Phosphate-containing Compound Metabolic Process Regulation Of Phosphorylation Regulation Of Kinase Activity Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Cellular Response To Stress Positive Regulation Of Catalytic Activity Regulation Of Cell Death Regulation Of Catalytic Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cell Death Regulation Of Cell Adhesion Neuron Projection Morphogenesis Regulation Of MAP Kinase Activity Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Cell Morphogenesis Involved In Differentiation Regulation Of Signaling Neuron Projection Development Axon Guidance Negative Regulation Of Phosphorylation Cell Projection Morphogenesis Positive Regulation Of Phosphorylation Nervous System Development Cell Part Morphogenesis Response To Oxidative Stress Positive Regulation Of Protein Modification Process Positive Regulation Of Metabolic Process Positive Regulation Of MAPK Cascade Anatomical Structure Morphogenesis Negative Regulation Of MAPK Cascade Peptidyl-amino Acid Modification Neuron Development Response To Stimulus Regulation Of JNK Cascade Positive Regulation Of Kinase Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Stress-activated MAPK Cascade	Cellular Metabolic Process Organelle Organization Regulation Of Gene Expression By Genetic Imprinting Gene Expression Genetic Imprinting Positive Regulation Of Histone Methylation Negative Regulation Of Male Germ Cell Proliferation Regulation Of Histone Methylation Positive Regulation Of Protein Modification Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Positive Regulation Of Histone Modification Negative Regulation Of Gene Expression, Epigenetic Cellular Nitrogen Compound Metabolic Process Regulation Of Male Germ Cell Proliferation Dihydrobiopterin Metabolic Process Cell Communication By Chemical Coupling S-adenosylmethioninamine Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Cytoskeleton Organization
Tagcloud ?		1alpha aav accordingly coactivator compartment conditional deleterious dysregulation editing myb mybbp1a nigra nucleolar nucleolus occupied paris parkin pd peroxisome pgc ppargamma proliferator purification rdna ribosome rrna substantia suppresses transcriptionally
Tagcloud (Difference) ?		1alpha aav accordingly coactivator compartment conditional deleterious dysregulation editing myb mybbp1a nigra nucleolar nucleolus occupied paris parkin pd peroxisome pgc ppargamma proliferator purification rdna ribosome rrna substantia suppresses transcriptionally
Tagcloud (Intersection) ?